Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.23/1127 |
Resumo: | Retinoic acid (RA) and ghrelin levels are altered in human hypoplastic lungs when compared to healthy lungs. Although considerable data have been obtained about RA, ghrelin and bombesin in the congenital diaphragmatic hernia (CDH) rat model, neuroendocrine factors have never been associated with the RA signalling pathway in this animal model. In this study, the interaction between neuroendocrine factors and RA was explored in the CDH rat model. The authors found that normal fetal lung explants treated with RA, bombesin and ghrelin showed an increase in lung growth. Hypoplastic lungs presented higher expression levels of the RA receptors α and γ. Moreover bombesin and ghrelin supplementation, in vitro, to normal lungs increased RA receptor α/γ expression whereas administration of bombesin and ghrelin antagonists to normal and hypoplastic lungs decreased it. These data reveal for the first time that there is a link between neuroendocrine factors and RA, and that neuroendocrine factors sensitise the lung to the RA action through RA receptor modulation. |
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Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung developmentHernias Diafragmáticas CongénitasReceptor X Retinoide alfaRatosReceptor X Retinoide gamaRetinoic acid (RA) and ghrelin levels are altered in human hypoplastic lungs when compared to healthy lungs. Although considerable data have been obtained about RA, ghrelin and bombesin in the congenital diaphragmatic hernia (CDH) rat model, neuroendocrine factors have never been associated with the RA signalling pathway in this animal model. In this study, the interaction between neuroendocrine factors and RA was explored in the CDH rat model. The authors found that normal fetal lung explants treated with RA, bombesin and ghrelin showed an increase in lung growth. Hypoplastic lungs presented higher expression levels of the RA receptors α and γ. Moreover bombesin and ghrelin supplementation, in vitro, to normal lungs increased RA receptor α/γ expression whereas administration of bombesin and ghrelin antagonists to normal and hypoplastic lungs decreased it. These data reveal for the first time that there is a link between neuroendocrine factors and RA, and that neuroendocrine factors sensitise the lung to the RA action through RA receptor modulation.Repositório Científico do Hospital de BragaPereira-Terra, PMoura, RSNogueira-Silva, CCorreia-Pinto, J2016-10-14T15:17:37Z2015-08-01T00:00:00Z2015-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1127engJ Physiol. 2015 Aug 1;593(15):3301-11.10.1113/JP270477info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:57Zoai:repositorio.hospitaldebraga.pt:10400.23/1127Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:41.208877Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
title |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
spellingShingle |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development Pereira-Terra, P Hernias Diafragmáticas Congénitas Receptor X Retinoide alfa Ratos Receptor X Retinoide gama |
title_short |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
title_full |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
title_fullStr |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
title_full_unstemmed |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
title_sort |
Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development |
author |
Pereira-Terra, P |
author_facet |
Pereira-Terra, P Moura, RS Nogueira-Silva, C Correia-Pinto, J |
author_role |
author |
author2 |
Moura, RS Nogueira-Silva, C Correia-Pinto, J |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Hospital de Braga |
dc.contributor.author.fl_str_mv |
Pereira-Terra, P Moura, RS Nogueira-Silva, C Correia-Pinto, J |
dc.subject.por.fl_str_mv |
Hernias Diafragmáticas Congénitas Receptor X Retinoide alfa Ratos Receptor X Retinoide gama |
topic |
Hernias Diafragmáticas Congénitas Receptor X Retinoide alfa Ratos Receptor X Retinoide gama |
description |
Retinoic acid (RA) and ghrelin levels are altered in human hypoplastic lungs when compared to healthy lungs. Although considerable data have been obtained about RA, ghrelin and bombesin in the congenital diaphragmatic hernia (CDH) rat model, neuroendocrine factors have never been associated with the RA signalling pathway in this animal model. In this study, the interaction between neuroendocrine factors and RA was explored in the CDH rat model. The authors found that normal fetal lung explants treated with RA, bombesin and ghrelin showed an increase in lung growth. Hypoplastic lungs presented higher expression levels of the RA receptors α and γ. Moreover bombesin and ghrelin supplementation, in vitro, to normal lungs increased RA receptor α/γ expression whereas administration of bombesin and ghrelin antagonists to normal and hypoplastic lungs decreased it. These data reveal for the first time that there is a link between neuroendocrine factors and RA, and that neuroendocrine factors sensitise the lung to the RA action through RA receptor modulation. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01T00:00:00Z 2015-08-01T00:00:00Z 2016-10-14T15:17:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.23/1127 |
url |
http://hdl.handle.net/10400.23/1127 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Physiol. 2015 Aug 1;593(15):3301-11. 10.1113/JP270477 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130425195495424 |