Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/50174 |
Resumo: | Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
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Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive functionastrocytebehaviorlocal field potentialneuronal morphologyoscillationsScience & TechnologyAstrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive functionAstrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with D-serine completely restores hippocampal-prefrontal theta synchronization and rescues the spatial memory and long-term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function.Foundation for Science and Technology (FCT) project (PTDC/SAU-NSC/118194/ 2010) to V.M.S., S.G.G., G.T., M.M., J.S.R., J.S.C., J.F.O. and fellowships (SFRH/BD/ 89714/2012 to V.M.S., SFRH/BPD/97281/ 2013 to J.F.O., SFRH/BD/101298/2014 to S.G.G., IF/00328/2015 to JFO, IF/01079/ 2014 to LP); Marie Curie Fellowship FP7- PEOPLE-2010-IEF 273936 and BIAL Foundation Grants 207/14 to J.F.O. and 427/14 to LP; Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01- 0145-FEDER-000013); FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and National funds, through the FCT (POCI-01- 0145-FEDER-007038)info:eu-repo/semantics/publishedVersionWileyUniversidade do MinhoSardinha, Vanessa Alexandra MoraisGomes, Sónia Isabel Nunes GuerraCampos, Inês Caetano CostaTavares, Gabriela PiresMartins, Manuella MendesReis, Joana Vanessa SantosCorreia, Joana Sofia SilvaCastro, Andreia Cristiana TeixeiraPinto, LuísaSousa, NunoOliveira, João F.2017-122017-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/50174eng0894-14911098-113610.1002/glia.2320528885722http://onlinelibrary.wiley.com/doi/10.1002/glia.23205/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:24Zoai:repositorium.sdum.uminho.pt:1822/50174Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:02:00.144352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| title |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| spellingShingle |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function Sardinha, Vanessa Alexandra Morais astrocyte behavior local field potential neuronal morphology oscillations Science & Technology |
| title_short |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| title_full |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| title_fullStr |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| title_full_unstemmed |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| title_sort |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| author |
Sardinha, Vanessa Alexandra Morais |
| author_facet |
Sardinha, Vanessa Alexandra Morais Gomes, Sónia Isabel Nunes Guerra Campos, Inês Caetano Costa Tavares, Gabriela Pires Martins, Manuella Mendes Reis, Joana Vanessa Santos Correia, Joana Sofia Silva Castro, Andreia Cristiana Teixeira Pinto, Luísa Sousa, Nuno Oliveira, João F. |
| author_role |
author |
| author2 |
Gomes, Sónia Isabel Nunes Guerra Campos, Inês Caetano Costa Tavares, Gabriela Pires Martins, Manuella Mendes Reis, Joana Vanessa Santos Correia, Joana Sofia Silva Castro, Andreia Cristiana Teixeira Pinto, Luísa Sousa, Nuno Oliveira, João F. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Sardinha, Vanessa Alexandra Morais Gomes, Sónia Isabel Nunes Guerra Campos, Inês Caetano Costa Tavares, Gabriela Pires Martins, Manuella Mendes Reis, Joana Vanessa Santos Correia, Joana Sofia Silva Castro, Andreia Cristiana Teixeira Pinto, Luísa Sousa, Nuno Oliveira, João F. |
| dc.subject.por.fl_str_mv |
astrocyte behavior local field potential neuronal morphology oscillations Science & Technology |
| topic |
astrocyte behavior local field potential neuronal morphology oscillations Science & Technology |
| description |
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-12 2017-12-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/50174 |
| url |
http://hdl.handle.net/1822/50174 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0894-1491 1098-1136 10.1002/glia.23205 28885722 http://onlinelibrary.wiley.com/doi/10.1002/glia.23205/abstract |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
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Wiley |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132420401790976 |