Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis

Detalhes bibliográficos
Autor(a) principal: Morais, Juliana
Data de Publicação: 2020
Outros Autores: Marques, Cláudia, Teixeira, Diana, Durão, Catarina, Faria, Ana, Brito, Sara, Cardoso, Manuela, Macedo, Israel, Pereira, Esmeralda, Tomé, Teresa, Calhau, Conceição
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/105897
Resumo: This study was supported by Milupa DN-ELN 2017 grant from the Portuguese Neonatal Society, by ERDF through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização – COMPETE2020 and by National Funds through FCT – Fundação para a Ciência e a Tecnologia within CINTESIS,R&D Unit (reference UID/IC/4255/2013).
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spelling Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesisLactobacillusmaternal microbiotameconiumpreterm neonatesMicrobiologyGastroenterologyMicrobiology (medical)Infectious DiseasesSDG 3 - Good Health and Well-beingThis study was supported by Milupa DN-ELN 2017 grant from the Portuguese Neonatal Society, by ERDF through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização – COMPETE2020 and by National Funds through FCT – Fundação para a Ciência e a Tecnologia within CINTESIS,R&D Unit (reference UID/IC/4255/2013).Growing evidence suggests that maternal microbiota can influence the neonates’ gut colonization. However, the mechanisms of vertical bacterial transmission remain poorly defined. We believed that the first colonizers of the newborn come from the mother’s gut and vagina during pregnancy and that this is independent of the mode of delivery. We conducted an observational longitudinal study to evaluate the link between the maternal gut microbiota and the meconium’s microbiota in extremely and very preterm neonates. Bacterial DNA was extracted from samples and specific bacterial groups were quantified by RT-PCR. In this cohort of 117 preterm neonates, we detected bacterial DNA in 88% of meconium samples. Meconium microbiota of neonates born after 28 gestational weeks (very preterm neonates) showed stronger correlations with their mothers’ fecal microbiota. However, neonates born before 28 gestational weeks (extremely preterm neonates) had more Lactobacillus–genus that dominated the vaginal microbiota–than very preterm neonates, regardless of the mode of delivery. Collectively, these data support the hypothesis that maternal bacteria from the gut and vagina can play a role in shaping neonates’ gut microbiota and that mother-to-infant bacterial transmission is a controlled and time-specific process. ClinicalTrials.gov Identifier: NCT03663556.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNMorais, JulianaMarques, CláudiaTeixeira, DianaDurão, CatarinaFaria, AnaBrito, SaraCardoso, ManuelaMacedo, IsraelPereira, EsmeraldaTomé, TeresaCalhau, Conceição2020-10-19T23:24:45Z2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/105897eng1949-0976PURE: 19218950https://doi.org/10.1080/19490976.2020.1785804info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:51:02Zoai:run.unl.pt:10362/105897Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:36.676395Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
title Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
spellingShingle Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
Morais, Juliana
Lactobacillus
maternal microbiota
meconium
preterm neonates
Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
title_full Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
title_fullStr Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
title_full_unstemmed Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
title_sort Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis
author Morais, Juliana
author_facet Morais, Juliana
Marques, Cláudia
Teixeira, Diana
Durão, Catarina
Faria, Ana
Brito, Sara
Cardoso, Manuela
Macedo, Israel
Pereira, Esmeralda
Tomé, Teresa
Calhau, Conceição
author_role author
author2 Marques, Cláudia
Teixeira, Diana
Durão, Catarina
Faria, Ana
Brito, Sara
Cardoso, Manuela
Macedo, Israel
Pereira, Esmeralda
Tomé, Teresa
Calhau, Conceição
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Morais, Juliana
Marques, Cláudia
Teixeira, Diana
Durão, Catarina
Faria, Ana
Brito, Sara
Cardoso, Manuela
Macedo, Israel
Pereira, Esmeralda
Tomé, Teresa
Calhau, Conceição
dc.subject.por.fl_str_mv Lactobacillus
maternal microbiota
meconium
preterm neonates
Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Lactobacillus
maternal microbiota
meconium
preterm neonates
Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases
SDG 3 - Good Health and Well-being
description This study was supported by Milupa DN-ELN 2017 grant from the Portuguese Neonatal Society, by ERDF through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização – COMPETE2020 and by National Funds through FCT – Fundação para a Ciência e a Tecnologia within CINTESIS,R&D Unit (reference UID/IC/4255/2013).
publishDate 2020
dc.date.none.fl_str_mv 2020-10-19T23:24:45Z
2020-11
2020-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/105897
url http://hdl.handle.net/10362/105897
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1949-0976
PURE: 19218950
https://doi.org/10.1080/19490976.2020.1785804
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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