Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams

Detalhes bibliográficos
Autor(a) principal: Alves, Nuno Guerreiro
Data de Publicação: 2021
Outros Autores: Alves, Américo J. S., Soares, Maria I. L., Pinho e Melo, Teresa M. V. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/107438
https://doi.org/10.1002/adsc.202100013
Resumo: Spirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism.
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spelling Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactamsβ-lactamsδ-lactamsspiro-β-lactamsspiro-δ-lactamspenicillanatesspirocyclizationSpirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism.Wiley Online Library2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107438http://hdl.handle.net/10316/107438https://doi.org/10.1002/adsc.202100013eng1615-41501615-4169Alves, Nuno GuerreiroAlves, Américo J. S.Soares, Maria I. L.Pinho e Melo, Teresa M. V. D.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-17T08:39:26Zoai:estudogeral.uc.pt:10316/107438Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:47.671771Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
title Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
spellingShingle Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
Alves, Nuno Guerreiro
β-lactams
δ-lactams
spiro-β-lactams
spiro-δ-lactams
penicillanates
spirocyclization
title_short Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
title_full Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
title_fullStr Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
title_full_unstemmed Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
title_sort Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
author Alves, Nuno Guerreiro
author_facet Alves, Nuno Guerreiro
Alves, Américo J. S.
Soares, Maria I. L.
Pinho e Melo, Teresa M. V. D.
author_role author
author2 Alves, Américo J. S.
Soares, Maria I. L.
Pinho e Melo, Teresa M. V. D.
author2_role author
author
author
dc.contributor.author.fl_str_mv Alves, Nuno Guerreiro
Alves, Américo J. S.
Soares, Maria I. L.
Pinho e Melo, Teresa M. V. D.
dc.subject.por.fl_str_mv β-lactams
δ-lactams
spiro-β-lactams
spiro-δ-lactams
penicillanates
spirocyclization
topic β-lactams
δ-lactams
spiro-β-lactams
spiro-δ-lactams
penicillanates
spirocyclization
description Spirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/107438
http://hdl.handle.net/10316/107438
https://doi.org/10.1002/adsc.202100013
url http://hdl.handle.net/10316/107438
https://doi.org/10.1002/adsc.202100013
dc.language.iso.fl_str_mv eng
language eng
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1615-4169
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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