Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107438 https://doi.org/10.1002/adsc.202100013 |
Resumo: | Spirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism. |
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Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactamsβ-lactamsδ-lactamsspiro-β-lactamsspiro-δ-lactamspenicillanatesspirocyclizationSpirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism.Wiley Online Library2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107438http://hdl.handle.net/10316/107438https://doi.org/10.1002/adsc.202100013eng1615-41501615-4169Alves, Nuno GuerreiroAlves, Américo J. S.Soares, Maria I. L.Pinho e Melo, Teresa M. V. D.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-17T08:39:26Zoai:estudogeral.uc.pt:10316/107438Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:47.671771Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
title |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
spellingShingle |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams Alves, Nuno Guerreiro β-lactams δ-lactams spiro-β-lactams spiro-δ-lactams penicillanates spirocyclization |
title_short |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
title_full |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
title_fullStr |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
title_full_unstemmed |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
title_sort |
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams |
author |
Alves, Nuno Guerreiro |
author_facet |
Alves, Nuno Guerreiro Alves, Américo J. S. Soares, Maria I. L. Pinho e Melo, Teresa M. V. D. |
author_role |
author |
author2 |
Alves, Américo J. S. Soares, Maria I. L. Pinho e Melo, Teresa M. V. D. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alves, Nuno Guerreiro Alves, Américo J. S. Soares, Maria I. L. Pinho e Melo, Teresa M. V. D. |
dc.subject.por.fl_str_mv |
β-lactams δ-lactams spiro-β-lactams spiro-δ-lactams penicillanates spirocyclization |
topic |
β-lactams δ-lactams spiro-β-lactams spiro-δ-lactams penicillanates spirocyclization |
description |
Spirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107438 http://hdl.handle.net/10316/107438 https://doi.org/10.1002/adsc.202100013 |
url |
http://hdl.handle.net/10316/107438 https://doi.org/10.1002/adsc.202100013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1615-4150 1615-4169 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Wiley Online Library |
publisher.none.fl_str_mv |
Wiley Online Library |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134124414337024 |