Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence

Detalhes bibliográficos
Autor(a) principal: Martins, João Martin
Data de Publicação: 2014
Outros Autores: Vale, Sónia do, Martins, Ana Filipa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/45188
Resumo: Copyright © 2014 Joao Martin Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidenceCopyright © 2014 Joao Martin Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Introduction. Adrenal glands play a major role in the control of blood pressure and mild defects of steroidogenesis and/or inappropriate control of mineralocorticoid production have been reported in high blood pressure (HBP). Patients and Methods. We used a specific protocol for the evaluation of 100 consecutive patients with inappropriate or recent onset HBP. Specific methods were used to confirm HBP and to diagnose secondary forms of HBP. In addition we tested adrenal steroidogenesis with the common cosyntropin test, modified to include the simultaneous measurement of renin and aldosterone besides 17-hydroxyprogesterone (17OHP) and 11-deoxycortisol (S). Results. Secondary forms of HBP were diagnosed in 32 patients, including 14 patients with primary hyperaldosteronism (PA) (14%) and 10 patients with pheochromocytoma (10%). Mild defects of the 21-hydroxylase (21OHD) and 11-hydroxylase (11OHD) enzymes were common (42%). ACTH-dependent aldosterone secretion was found in most patients (54%) and characteristically in those with mild defects of adrenal steroidogenesis (>60%), PA (>75%), and otherwise in patients with apparent essential HBP (EHBP) (32%). Discussion. Mild defects of adrenal steroidogenesis are common in patients with HBP, occurring in almost half of the patients. In those patients as well as in patients with apparent EHBP, aldosterone secretion is commonly dependent on ACTH.Hindawi Publishing CorporationRepositório da Universidade de LisboaMartins, João MartinVale, Sónia doMartins, Ana Filipa2020-12-09T14:20:54Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45188engInt J Endocrinol. 2014;2014:295724.1687-833710.1155/2014/2957241687-8345info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:46:49Zoai:repositorio.ul.pt:10451/45188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:57:41.222623Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
title Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
spellingShingle Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
Martins, João Martin
title_short Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
title_full Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
title_fullStr Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
title_full_unstemmed Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
title_sort Mild adrenal steroidogenic defects and ACTH-dependent aldosterone secretion in high blood pressure : preliminary evidence
author Martins, João Martin
author_facet Martins, João Martin
Vale, Sónia do
Martins, Ana Filipa
author_role author
author2 Vale, Sónia do
Martins, Ana Filipa
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Martins, João Martin
Vale, Sónia do
Martins, Ana Filipa
description Copyright © 2014 Joao Martin Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2020-12-09T14:20:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/45188
url http://hdl.handle.net/10451/45188
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Endocrinol. 2014;2014:295724.
1687-8337
10.1155/2014/295724
1687-8345
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134521491193856

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