Working memory during spontaneous migraine attacks: an fMRI study

Detalhes bibliográficos
Autor(a) principal: Ruiz-Tagle, A.
Data de Publicação: 2023
Outros Autores: Figueiredo, Patrícia, Pinto, Joana, Vilela, Pedro, Martins, Isabel Pavão, Gil-Gouveia, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/42938
Resumo: Objective: To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI). Background: Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown. Methods: In a fMRI within-subject test-retest design study, eleven women (32 years of age, average) with episodic migraine were evaluated twice, first during a spontaneous migraine attack, and again in a pain-free period. Each session consisted in a cognitive assessment and fMRI while performing a working memory task (N-back). Results: Cognitive test scores were lower during the ictal session than in the pain-free session. Regions typically associated with working memory were activated during the N-back task in both sessions. A voxel wise between session comparison showed significantly greater activation in the left frontal pole and orbitofrontal cortex during the attack relative to the interictal phase. Conclusion: Migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while executing a verbal working memory task during a spontaneous migraine attack when compared to the interictal state. Given the association of these regions with pain processing and inhibitory control, these findings suggest that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks, a neural signature of their cognitive difficulties.
id RCAP_23a357a70164c913eee94359f99005f3
oai_identifier_str oai:repositorio.ucp.pt:10400.14/42938
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Working memory during spontaneous migraine attacks: an fMRI studyCognitionfMRIN-backSpontaneous migraine attackTest-retestObjective: To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI). Background: Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown. Methods: In a fMRI within-subject test-retest design study, eleven women (32 years of age, average) with episodic migraine were evaluated twice, first during a spontaneous migraine attack, and again in a pain-free period. Each session consisted in a cognitive assessment and fMRI while performing a working memory task (N-back). Results: Cognitive test scores were lower during the ictal session than in the pain-free session. Regions typically associated with working memory were activated during the N-back task in both sessions. A voxel wise between session comparison showed significantly greater activation in the left frontal pole and orbitofrontal cortex during the attack relative to the interictal phase. Conclusion: Migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while executing a verbal working memory task during a spontaneous migraine attack when compared to the interictal state. Given the association of these regions with pain processing and inhibitory control, these findings suggest that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks, a neural signature of their cognitive difficulties.Veritati - Repositório Institucional da Universidade Católica PortuguesaRuiz-Tagle, A.Figueiredo, PatríciaPinto, JoanaVilela, PedroMartins, Isabel PavãoGil-Gouveia, Raquel2023-10-31T11:17:21Z2023-10-172023-10-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/42938eng1590-187410.1007/s10072-023-07120-085174232135378474196D18-4F7A-E69D/3377210info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-07T01:33:11Zoai:repositorio.ucp.pt:10400.14/42938Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:51.019554Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Working memory during spontaneous migraine attacks: an fMRI study
title Working memory during spontaneous migraine attacks: an fMRI study
spellingShingle Working memory during spontaneous migraine attacks: an fMRI study
Ruiz-Tagle, A.
Cognition
fMRI
N-back
Spontaneous migraine attack
Test-retest
title_short Working memory during spontaneous migraine attacks: an fMRI study
title_full Working memory during spontaneous migraine attacks: an fMRI study
title_fullStr Working memory during spontaneous migraine attacks: an fMRI study
title_full_unstemmed Working memory during spontaneous migraine attacks: an fMRI study
title_sort Working memory during spontaneous migraine attacks: an fMRI study
author Ruiz-Tagle, A.
author_facet Ruiz-Tagle, A.
Figueiredo, Patrícia
Pinto, Joana
Vilela, Pedro
Martins, Isabel Pavão
Gil-Gouveia, Raquel
author_role author
author2 Figueiredo, Patrícia
Pinto, Joana
Vilela, Pedro
Martins, Isabel Pavão
Gil-Gouveia, Raquel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Ruiz-Tagle, A.
Figueiredo, Patrícia
Pinto, Joana
Vilela, Pedro
Martins, Isabel Pavão
Gil-Gouveia, Raquel
dc.subject.por.fl_str_mv Cognition
fMRI
N-back
Spontaneous migraine attack
Test-retest
topic Cognition
fMRI
N-back
Spontaneous migraine attack
Test-retest
description Objective: To investigate the neural correlates of working memory during a spontaneous migraine attack compared to the interictal phase, using functional magnetic resonance imaging (fMRI). Background: Cognitive disturbances are commonly observed during migraine attacks, particularly in the headache phase. However, the neural basis of these changes remains unknown. Methods: In a fMRI within-subject test-retest design study, eleven women (32 years of age, average) with episodic migraine were evaluated twice, first during a spontaneous migraine attack, and again in a pain-free period. Each session consisted in a cognitive assessment and fMRI while performing a working memory task (N-back). Results: Cognitive test scores were lower during the ictal session than in the pain-free session. Regions typically associated with working memory were activated during the N-back task in both sessions. A voxel wise between session comparison showed significantly greater activation in the left frontal pole and orbitofrontal cortex during the attack relative to the interictal phase. Conclusion: Migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while executing a verbal working memory task during a spontaneous migraine attack when compared to the interictal state. Given the association of these regions with pain processing and inhibitory control, these findings suggest that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks, a neural signature of their cognitive difficulties.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-31T11:17:21Z
2023-10-17
2023-10-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/42938
url http://hdl.handle.net/10400.14/42938
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1590-1874
10.1007/s10072-023-07120-0
85174232135
37847419
6D18-4F7A-E69D/3377210
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134150236569600