Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/44740 |
Resumo: | Purpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP. |
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Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter studyRetinopatia da PrematuridadeRecém-Nascido PrematuroBiomarcadoresRetinopathy of PrematurityInfant, PrematureBiomarkersPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.Repositório ComumFevereiro-Martins, MSantos, ACMarques-Neves, CGuimarães, HBicho, MAfonso, CFerreira, JEspírito Santo, RTeixeira, FRosa, RCarneiro, CVFerreira, MMatos, TNeiva, LPereira, SAires, SParreira, RMelnik, ZFaria, JTeixeira, JBarros, PAlmeida, JMalheiro, BRodrigues, PCAlbuquerque, LFreitas, ABarros, PKotchekova, NFreitas, RSilveira, ACFerreira, AMorais, BTeixeira, SMota, MGuerra, MCoimbra, LGigante, JFerreira, MLapa, PMonteiro, MAlfaiate, MRodrigues, TPina, TRosário, MSilva, RBreda, JBazenga, FPinto, JA2023-05-08T22:05:01Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/44740engGraefes Arch Clin Exp Ophthalmol . 2023 May 2. doi: 10.1007/s00417-023-06072-7.10.1007/s00417-023-06072-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-10T06:15:22Zoai:comum.rcaap.pt:10400.26/44740Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:51:04.029085Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
title |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
spellingShingle |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study Fevereiro-Martins, M Retinopatia da Prematuridade Recém-Nascido Prematuro Biomarcadores Retinopathy of Prematurity Infant, Premature Biomarkers |
title_short |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
title_full |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
title_fullStr |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
title_full_unstemmed |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
title_sort |
Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study |
author |
Fevereiro-Martins, M |
author_facet |
Fevereiro-Martins, M Santos, AC Marques-Neves, C Guimarães, H Bicho, M Afonso, C Ferreira, J Espírito Santo, R Teixeira, F Rosa, R Carneiro, CV Ferreira, M Matos, T Neiva, L Pereira, S Aires, S Parreira, R Melnik, Z Faria, J Teixeira, J Barros, P Almeida, J Malheiro, B Rodrigues, PC Albuquerque, L Freitas, A Kotchekova, N Freitas, R Silveira, AC Ferreira, A Morais, B Teixeira, S Mota, M Guerra, M Coimbra, L Gigante, J Lapa, P Monteiro, M Alfaiate, M Rodrigues, T Pina, T Rosário, M Silva, R Breda, J Bazenga, F Pinto, JA |
author_role |
author |
author2 |
Santos, AC Marques-Neves, C Guimarães, H Bicho, M Afonso, C Ferreira, J Espírito Santo, R Teixeira, F Rosa, R Carneiro, CV Ferreira, M Matos, T Neiva, L Pereira, S Aires, S Parreira, R Melnik, Z Faria, J Teixeira, J Barros, P Almeida, J Malheiro, B Rodrigues, PC Albuquerque, L Freitas, A Kotchekova, N Freitas, R Silveira, AC Ferreira, A Morais, B Teixeira, S Mota, M Guerra, M Coimbra, L Gigante, J Lapa, P Monteiro, M Alfaiate, M Rodrigues, T Pina, T Rosário, M Silva, R Breda, J Bazenga, F Pinto, JA |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Fevereiro-Martins, M Santos, AC Marques-Neves, C Guimarães, H Bicho, M Afonso, C Ferreira, J Espírito Santo, R Teixeira, F Rosa, R Carneiro, CV Ferreira, M Matos, T Neiva, L Pereira, S Aires, S Parreira, R Melnik, Z Faria, J Teixeira, J Barros, P Almeida, J Malheiro, B Rodrigues, PC Albuquerque, L Freitas, A Barros, P Kotchekova, N Freitas, R Silveira, AC Ferreira, A Morais, B Teixeira, S Mota, M Guerra, M Coimbra, L Gigante, J Ferreira, M Lapa, P Monteiro, M Alfaiate, M Rodrigues, T Pina, T Rosário, M Silva, R Breda, J Bazenga, F Pinto, JA |
dc.subject.por.fl_str_mv |
Retinopatia da Prematuridade Recém-Nascido Prematuro Biomarcadores Retinopathy of Prematurity Infant, Premature Biomarkers |
topic |
Retinopatia da Prematuridade Recém-Nascido Prematuro Biomarcadores Retinopathy of Prematurity Infant, Premature Biomarkers |
description |
Purpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-08T22:05:01Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/44740 |
url |
http://hdl.handle.net/10400.26/44740 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Graefes Arch Clin Exp Ophthalmol . 2023 May 2. doi: 10.1007/s00417-023-06072-7. 10.1007/s00417-023-06072-7 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131589533237248 |