Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/109482 |
Resumo: | Funding: This research and the article processing cost were funded by EU Horizon 2020 research & innovation programme under grant agreement N. 760891 project CHIC. M.S.M. also acknowledges the financial support from Fundação para a Ciência e Tecnologia for her PhD scholarship (SFRD/BD/145551/2019). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory11β,13-dihydrolactucin11β,13-dihydrolactucopicrinCalcineurinLactucinLactucopicrinNFATFood ScienceNutrition and DieteticsSDG 3 - Good Health and Well-beingFunding: This research and the article processing cost were funded by EU Horizon 2020 research & innovation programme under grant agreement N. 760891 project CHIC. M.S.M. also acknowledges the financial support from Fundação para a Ciência e Tecnologia for her PhD scholarship (SFRD/BD/145551/2019).Cichorium intybus L. has recently gained major attention due to large quantities of health-promoting compounds in its roots, such as inulin and sesquiterpene lactones (SLs). Chicory is the main dietary source of SLs, which have underexplored bioactive potential. In this study, we assessed the capacity of SLs to permeate the intestinal barrier to become physiologically available, using in silico predictions and in vitro studies with the well-established cell model of the human intestinal mucosa (differentiated Caco-2 cells). The potential of SLs to modulate inflammatory responses through modulation of the nuclear factor of activated T-cells (NFAT) pathway was also evaluated, using a yeast reporter system. Lactucopicrin was revealed as the most permeable chicory SL in the intestinal barrier model, but it had low anti-inflammatory potential. The SL with the highest anti-inflammatory potential was 11β,13-dihydrolactucin, which inhibited up to 54% of Calcineurin-responsive zinc finger (Crz1) activation, concomitantly with the impairment of the nuclear accumulation of Crz1, the yeast orthologue of human NFAT.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMatos, Melanie S.Anastácio, José D.Allwood, J. WilliamCarregosa, DiogoMarques, DanielaSungurtas, JulieMcDougall, Gordon J.Menezes, ReginaMatias, Ana A.Stewart, DerekDos Santos, Cláudia Nunes2020-12-30T05:03:58Z2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/109482eng1422-8599PURE: 26662570https://doi.org/10.3390/nu12113547info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:53:49Zoai:run.unl.pt:10362/109482Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:41:27.810552Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| title |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| spellingShingle |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory Matos, Melanie S. 11β,13-dihydrolactucin 11β,13-dihydrolactucopicrin Calcineurin Lactucin Lactucopicrin NFAT Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| title_short |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| title_full |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| title_fullStr |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| title_full_unstemmed |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| title_sort |
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory |
| author |
Matos, Melanie S. |
| author_facet |
Matos, Melanie S. Anastácio, José D. Allwood, J. William Carregosa, Diogo Marques, Daniela Sungurtas, Julie McDougall, Gordon J. Menezes, Regina Matias, Ana A. Stewart, Derek Dos Santos, Cláudia Nunes |
| author_role |
author |
| author2 |
Anastácio, José D. Allwood, J. William Carregosa, Diogo Marques, Daniela Sungurtas, Julie McDougall, Gordon J. Menezes, Regina Matias, Ana A. Stewart, Derek Dos Santos, Cláudia Nunes |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Matos, Melanie S. Anastácio, José D. Allwood, J. William Carregosa, Diogo Marques, Daniela Sungurtas, Julie McDougall, Gordon J. Menezes, Regina Matias, Ana A. Stewart, Derek Dos Santos, Cláudia Nunes |
| dc.subject.por.fl_str_mv |
11β,13-dihydrolactucin 11β,13-dihydrolactucopicrin Calcineurin Lactucin Lactucopicrin NFAT Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| topic |
11β,13-dihydrolactucin 11β,13-dihydrolactucopicrin Calcineurin Lactucin Lactucopicrin NFAT Food Science Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| description |
Funding: This research and the article processing cost were funded by EU Horizon 2020 research & innovation programme under grant agreement N. 760891 project CHIC. M.S.M. also acknowledges the financial support from Fundação para a Ciência e Tecnologia for her PhD scholarship (SFRD/BD/145551/2019). |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-30T05:03:58Z 2020-11 2020-11-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/109482 |
| url |
http://hdl.handle.net/10362/109482 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1422-8599 PURE: 26662570 https://doi.org/10.3390/nu12113547 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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20 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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