Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/16940 https://doi.org/http://dx.doi.org/10.1016/j.archoralbio.2015.02.015 https://doi.org/10.1016/j.archoralbio.2015.02.015 |
Resumo: | Salivary a-amylase, a major protein in saliva, has been described as a marker for sympathetic nervous system activity, hence for metabolic energy balance. In this context, its expression in overweight and obesity is of interest. Rats fed with a diet enriched with sunflower oil differentially gained weight yielding two subgroups according to their susceptibility (OP) or resistance (OR) to obesity. Elevated plasmatic levels of leptin in the OP subgroup and altered plasmatic lipid profiles (lower triglycerides and higher total choles- terol/HDL ratio compared to controls) in OR subgroup were observed. Animals from OP subgroup presented higher a-amylase expression and activity even prior to the dietary treatment, suggesting that this salivary protein may constitute a putative indicator of susceptibility for fat tissue accumulation. After 18 weeks of high-fat diet consumption, salivary a-amylase levels did not significantly changed in OP subgroup, but increased 3-fold in OR subgroup. The raise of a-amylase for the latter might represent an adaptation to lower starch intake. These results suggest that salivary a-amylase secretion might be useful to predict susceptibility for weight gain induced by high-fat diet consumption. |
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Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in ratsWeight gainHigh-fat dietLeptinRatsSalivary amylaseSalivary a-amylase, a major protein in saliva, has been described as a marker for sympathetic nervous system activity, hence for metabolic energy balance. In this context, its expression in overweight and obesity is of interest. Rats fed with a diet enriched with sunflower oil differentially gained weight yielding two subgroups according to their susceptibility (OP) or resistance (OR) to obesity. Elevated plasmatic levels of leptin in the OP subgroup and altered plasmatic lipid profiles (lower triglycerides and higher total choles- terol/HDL ratio compared to controls) in OR subgroup were observed. Animals from OP subgroup presented higher a-amylase expression and activity even prior to the dietary treatment, suggesting that this salivary protein may constitute a putative indicator of susceptibility for fat tissue accumulation. After 18 weeks of high-fat diet consumption, salivary a-amylase levels did not significantly changed in OP subgroup, but increased 3-fold in OR subgroup. The raise of a-amylase for the latter might represent an adaptation to lower starch intake. These results suggest that salivary a-amylase secretion might be useful to predict susceptibility for weight gain induced by high-fat diet consumption.This paper is funded by FEDER Funds through the Operational Programme for Competitiveness Factors-COMPETE and National Funds through FCT-Foundation for Science and Technology under the Strategic Projects PEst-C/AGR/UI01, PEst-OE/AGR/ UI0115/2014, 15/2011, PEst-C/SAU/LA0001/2011 and PEst-C/QUI/ UI0062/2011. Authors acknowledge also the financial support from the Portuguese Science Foundation (FCT) in the form of Post- Doctoral grant (SFRH/BPD/63240/2009) of Elsa Lamy. The Portu- guese Science Foundation (FCT) played no role in the develop- ment of the present work or upon its submission for publication.ELSEVIER2016-01-27T16:53:43Z2016-01-272015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/16940https://doi.org/http://dx.doi.org/10.1016/j.archoralbio.2015.02.015http://hdl.handle.net/10174/16940https://doi.org/10.1016/j.archoralbio.2015.02.015engRodrigues L, Mouta R, Costa AR, Pereira A, Capela e Silva F, Amado F, Antunes CM, Lamy E. Effects of high fat diet on salivary a-amylase, serum parameters and food consumption in rats. Archives of Oral Biology 2015; 60: 854-62.ICAAM, ZOO, QUIndndacrc@uevora.ptapereira@uevora.ptfcs@uevora.ptndcmma@uevora.ptecsl@uevora.pt365Rodrigues, LMouta, RCosta, ARPereira, ACapela e Silva, FAmado, FAntunes, CMLamy, Einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:04:09Zoai:dspace.uevora.pt:10174/16940Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:09:13.927074Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
title |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
spellingShingle |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats Rodrigues, L Weight gain High-fat diet Leptin Rats Salivary amylase |
title_short |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
title_full |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
title_fullStr |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
title_full_unstemmed |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
title_sort |
Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats |
author |
Rodrigues, L |
author_facet |
Rodrigues, L Mouta, R Costa, AR Pereira, A Capela e Silva, F Amado, F Antunes, CM Lamy, E |
author_role |
author |
author2 |
Mouta, R Costa, AR Pereira, A Capela e Silva, F Amado, F Antunes, CM Lamy, E |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, L Mouta, R Costa, AR Pereira, A Capela e Silva, F Amado, F Antunes, CM Lamy, E |
dc.subject.por.fl_str_mv |
Weight gain High-fat diet Leptin Rats Salivary amylase |
topic |
Weight gain High-fat diet Leptin Rats Salivary amylase |
description |
Salivary a-amylase, a major protein in saliva, has been described as a marker for sympathetic nervous system activity, hence for metabolic energy balance. In this context, its expression in overweight and obesity is of interest. Rats fed with a diet enriched with sunflower oil differentially gained weight yielding two subgroups according to their susceptibility (OP) or resistance (OR) to obesity. Elevated plasmatic levels of leptin in the OP subgroup and altered plasmatic lipid profiles (lower triglycerides and higher total choles- terol/HDL ratio compared to controls) in OR subgroup were observed. Animals from OP subgroup presented higher a-amylase expression and activity even prior to the dietary treatment, suggesting that this salivary protein may constitute a putative indicator of susceptibility for fat tissue accumulation. After 18 weeks of high-fat diet consumption, salivary a-amylase levels did not significantly changed in OP subgroup, but increased 3-fold in OR subgroup. The raise of a-amylase for the latter might represent an adaptation to lower starch intake. These results suggest that salivary a-amylase secretion might be useful to predict susceptibility for weight gain induced by high-fat diet consumption. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01T00:00:00Z 2016-01-27T16:53:43Z 2016-01-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/16940 https://doi.org/http://dx.doi.org/10.1016/j.archoralbio.2015.02.015 http://hdl.handle.net/10174/16940 https://doi.org/10.1016/j.archoralbio.2015.02.015 |
url |
http://hdl.handle.net/10174/16940 https://doi.org/http://dx.doi.org/10.1016/j.archoralbio.2015.02.015 https://doi.org/10.1016/j.archoralbio.2015.02.015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rodrigues L, Mouta R, Costa AR, Pereira A, Capela e Silva F, Amado F, Antunes CM, Lamy E. Effects of high fat diet on salivary a-amylase, serum parameters and food consumption in rats. Archives of Oral Biology 2015; 60: 854-62. ICAAM, ZOO, QUI nd nd acrc@uevora.pt apereira@uevora.pt fcs@uevora.pt nd cmma@uevora.pt ecsl@uevora.pt 365 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
ELSEVIER |
publisher.none.fl_str_mv |
ELSEVIER |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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