NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106538 https://doi.org/10.3390/pharmaceutics12090867 |
Resumo: | Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reactive oxygen species, hyaluronic acid fragments and extracellular adenosine triphosphate (ATP). These DAMPs are recognized by pattern recognition receptors (PRRs) in innate immune cells, namely dendritic cells (DCs), leading to their maturation and migration to the draining lymph nodes where they activate naïve T lymphocytes. Among all PRRs, several studies emphasize the role of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome on the allergic contact dermatitis (ACD) sensitization phase. However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The elucidation of these key events might help to identify novel therapeutic strategies for ACD, as well as the development of nonanimal alternative methods for the identification and potency categorization of skin sensitizers. |
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NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystifyallergic contact dermatitisskin sensitizersDAMPsinflammasomeNLRP3Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reactive oxygen species, hyaluronic acid fragments and extracellular adenosine triphosphate (ATP). These DAMPs are recognized by pattern recognition receptors (PRRs) in innate immune cells, namely dendritic cells (DCs), leading to their maturation and migration to the draining lymph nodes where they activate naïve T lymphocytes. Among all PRRs, several studies emphasize the role of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome on the allergic contact dermatitis (ACD) sensitization phase. However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The elucidation of these key events might help to identify novel therapeutic strategies for ACD, as well as the development of nonanimal alternative methods for the identification and potency categorization of skin sensitizers.MDPI2020-09-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106538http://hdl.handle.net/10316/106538https://doi.org/10.3390/pharmaceutics12090867eng1999-4923Sebastião, Ana IsabelFerreira, IsabelBrites, GonçaloSilva, AnaNeves, Bruno MiguelCruz, Maria Teresainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-18T10:46:25Zoai:estudogeral.uc.pt:10316/106538Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:58.924361Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
title |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
spellingShingle |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify Sebastião, Ana Isabel allergic contact dermatitis skin sensitizers DAMPs inflammasome NLRP3 |
title_short |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
title_full |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
title_fullStr |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
title_full_unstemmed |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
title_sort |
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify |
author |
Sebastião, Ana Isabel |
author_facet |
Sebastião, Ana Isabel Ferreira, Isabel Brites, Gonçalo Silva, Ana Neves, Bruno Miguel Cruz, Maria Teresa |
author_role |
author |
author2 |
Ferreira, Isabel Brites, Gonçalo Silva, Ana Neves, Bruno Miguel Cruz, Maria Teresa |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Sebastião, Ana Isabel Ferreira, Isabel Brites, Gonçalo Silva, Ana Neves, Bruno Miguel Cruz, Maria Teresa |
dc.subject.por.fl_str_mv |
allergic contact dermatitis skin sensitizers DAMPs inflammasome NLRP3 |
topic |
allergic contact dermatitis skin sensitizers DAMPs inflammasome NLRP3 |
description |
Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reactive oxygen species, hyaluronic acid fragments and extracellular adenosine triphosphate (ATP). These DAMPs are recognized by pattern recognition receptors (PRRs) in innate immune cells, namely dendritic cells (DCs), leading to their maturation and migration to the draining lymph nodes where they activate naïve T lymphocytes. Among all PRRs, several studies emphasize the role of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome on the allergic contact dermatitis (ACD) sensitization phase. However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The elucidation of these key events might help to identify novel therapeutic strategies for ACD, as well as the development of nonanimal alternative methods for the identification and potency categorization of skin sensitizers. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106538 http://hdl.handle.net/10316/106538 https://doi.org/10.3390/pharmaceutics12090867 |
url |
http://hdl.handle.net/10316/106538 https://doi.org/10.3390/pharmaceutics12090867 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1999-4923 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134117920505856 |