NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify

Detalhes bibliográficos
Autor(a) principal: Sebastião, Ana Isabel
Data de Publicação: 2020
Outros Autores: Ferreira, Isabel, Brites, Gonçalo, Silva, Ana, Neves, Bruno Miguel, Cruz, Maria Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106538
https://doi.org/10.3390/pharmaceutics12090867
Resumo: Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reactive oxygen species, hyaluronic acid fragments and extracellular adenosine triphosphate (ATP). These DAMPs are recognized by pattern recognition receptors (PRRs) in innate immune cells, namely dendritic cells (DCs), leading to their maturation and migration to the draining lymph nodes where they activate naïve T lymphocytes. Among all PRRs, several studies emphasize the role of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome on the allergic contact dermatitis (ACD) sensitization phase. However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The elucidation of these key events might help to identify novel therapeutic strategies for ACD, as well as the development of nonanimal alternative methods for the identification and potency categorization of skin sensitizers.
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spelling NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystifyallergic contact dermatitisskin sensitizersDAMPsinflammasomeNLRP3Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reactive oxygen species, hyaluronic acid fragments and extracellular adenosine triphosphate (ATP). These DAMPs are recognized by pattern recognition receptors (PRRs) in innate immune cells, namely dendritic cells (DCs), leading to their maturation and migration to the draining lymph nodes where they activate naïve T lymphocytes. Among all PRRs, several studies emphasize the role of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome on the allergic contact dermatitis (ACD) sensitization phase. However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The elucidation of these key events might help to identify novel therapeutic strategies for ACD, as well as the development of nonanimal alternative methods for the identification and potency categorization of skin sensitizers.MDPI2020-09-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106538http://hdl.handle.net/10316/106538https://doi.org/10.3390/pharmaceutics12090867eng1999-4923Sebastião, Ana IsabelFerreira, IsabelBrites, GonçaloSilva, AnaNeves, Bruno MiguelCruz, Maria Teresainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-18T10:46:25Zoai:estudogeral.uc.pt:10316/106538Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:58.924361Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
title NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
spellingShingle NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
Sebastião, Ana Isabel
allergic contact dermatitis
skin sensitizers
DAMPs
inflammasome
NLRP3
title_short NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
title_full NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
title_fullStr NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
title_full_unstemmed NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
title_sort NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
author Sebastião, Ana Isabel
author_facet Sebastião, Ana Isabel
Ferreira, Isabel
Brites, Gonçalo
Silva, Ana
Neves, Bruno Miguel
Cruz, Maria Teresa
author_role author
author2 Ferreira, Isabel
Brites, Gonçalo
Silva, Ana
Neves, Bruno Miguel
Cruz, Maria Teresa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sebastião, Ana Isabel
Ferreira, Isabel
Brites, Gonçalo
Silva, Ana
Neves, Bruno Miguel
Cruz, Maria Teresa
dc.subject.por.fl_str_mv allergic contact dermatitis
skin sensitizers
DAMPs
inflammasome
NLRP3
topic allergic contact dermatitis
skin sensitizers
DAMPs
inflammasome
NLRP3
description Allergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reactive oxygen species, hyaluronic acid fragments and extracellular adenosine triphosphate (ATP). These DAMPs are recognized by pattern recognition receptors (PRRs) in innate immune cells, namely dendritic cells (DCs), leading to their maturation and migration to the draining lymph nodes where they activate naïve T lymphocytes. Among all PRRs, several studies emphasize the role of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome on the allergic contact dermatitis (ACD) sensitization phase. However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The elucidation of these key events might help to identify novel therapeutic strategies for ACD, as well as the development of nonanimal alternative methods for the identification and potency categorization of skin sensitizers.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-11
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106538
http://hdl.handle.net/10316/106538
https://doi.org/10.3390/pharmaceutics12090867
url http://hdl.handle.net/10316/106538
https://doi.org/10.3390/pharmaceutics12090867
dc.language.iso.fl_str_mv eng
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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