The main potentialities of resveratrol for drug delivery systems

Detalhes bibliográficos
Autor(a) principal: Ruivo, Joana
Data de Publicação: 2015
Outros Autores: Francisco, Cátia, Oliveira, Rita, Figueiras, Ana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.1590/S1984-82502015000300002
Texto Completo: http://hdl.handle.net/10316/109083
https://doi.org/10.1590/S1984-82502015000300002
Resumo: Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.
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spelling The main potentialities of resveratrol for drug delivery systemsNutraceuticalsNatural polyphenolsResveratrol/mechanisms of actionResveratrol/ therapeutic applicationsResveratrol/delivery systemsNutracêuticosPolifenóis naturaisResveratrol/mecanismo de açãoResveratrol/aplicações terapêuticasResveratrol/sistemas de liberaçãoResveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.O resveratrol (RSV) é um polifenol natural encontrado nas uvas, que se mostrou eficaz na prevenção e terapia de várias doenças. No entanto, apresenta propriedades físico-químicas desfavoráveis. Neste contexto, um número cada vez maior de estudos visando ao desenvolvimento de novos sistemas terapêuticos para a sua liberação vem sendo desenvolvido no sentido de ultrapassar estas desvantagens. Esta revisão discorre sobre os mecanismos de ação e aplicações terapêuticas do RSV. Finalmente, são abordadas algumas formulações de liberação controlada e vetorizada, testadas para administração do RSV, desenvolvidas com a finalidade de aumentar a biodisponibilidade do RSV.Universidade de Sao Paulo2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109083http://hdl.handle.net/10316/109083https://doi.org/10.1590/S1984-82502015000300002por1984-8250Ruivo, JoanaFrancisco, CátiaOliveira, RitaFigueiras, Anainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-27T08:38:36Zoai:estudogeral.uc.pt:10316/109083Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:17.664810Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The main potentialities of resveratrol for drug delivery systems
title The main potentialities of resveratrol for drug delivery systems
spellingShingle The main potentialities of resveratrol for drug delivery systems
The main potentialities of resveratrol for drug delivery systems
Ruivo, Joana
Nutraceuticals
Natural polyphenols
Resveratrol/mechanisms of action
Resveratrol/ therapeutic applications
Resveratrol/delivery systems
Nutracêuticos
Polifenóis naturais
Resveratrol/mecanismo de ação
Resveratrol/aplicações terapêuticas
Resveratrol/sistemas de liberação
Ruivo, Joana
Nutraceuticals
Natural polyphenols
Resveratrol/mechanisms of action
Resveratrol/ therapeutic applications
Resveratrol/delivery systems
Nutracêuticos
Polifenóis naturais
Resveratrol/mecanismo de ação
Resveratrol/aplicações terapêuticas
Resveratrol/sistemas de liberação
title_short The main potentialities of resveratrol for drug delivery systems
title_full The main potentialities of resveratrol for drug delivery systems
title_fullStr The main potentialities of resveratrol for drug delivery systems
The main potentialities of resveratrol for drug delivery systems
title_full_unstemmed The main potentialities of resveratrol for drug delivery systems
The main potentialities of resveratrol for drug delivery systems
title_sort The main potentialities of resveratrol for drug delivery systems
author Ruivo, Joana
author_facet Ruivo, Joana
Ruivo, Joana
Francisco, Cátia
Oliveira, Rita
Figueiras, Ana
Francisco, Cátia
Oliveira, Rita
Figueiras, Ana
author_role author
author2 Francisco, Cátia
Oliveira, Rita
Figueiras, Ana
author2_role author
author
author
dc.contributor.author.fl_str_mv Ruivo, Joana
Francisco, Cátia
Oliveira, Rita
Figueiras, Ana
dc.subject.por.fl_str_mv Nutraceuticals
Natural polyphenols
Resveratrol/mechanisms of action
Resveratrol/ therapeutic applications
Resveratrol/delivery systems
Nutracêuticos
Polifenóis naturais
Resveratrol/mecanismo de ação
Resveratrol/aplicações terapêuticas
Resveratrol/sistemas de liberação
topic Nutraceuticals
Natural polyphenols
Resveratrol/mechanisms of action
Resveratrol/ therapeutic applications
Resveratrol/delivery systems
Nutracêuticos
Polifenóis naturais
Resveratrol/mecanismo de ação
Resveratrol/aplicações terapêuticas
Resveratrol/sistemas de liberação
description Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109083
http://hdl.handle.net/10316/109083
https://doi.org/10.1590/S1984-82502015000300002
url http://hdl.handle.net/10316/109083
https://doi.org/10.1590/S1984-82502015000300002
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 1984-8250
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de Sao Paulo
publisher.none.fl_str_mv Universidade de Sao Paulo
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.1590/S1984-82502015000300002

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