Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/136340 |
Resumo: | FuEP/E039618/1 EP/J002577/1 EP/L002191/1 MERG-CT-2007-207292 no. 692335 VEGA 1/0489/21 APVV-19-0386 PD/00193/2012 UID/FIS/00068/2020 UID/Multi/04378/2020 |
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Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analoguesChemistry(all)Chemical Engineering(all)FuEP/E039618/1 EP/J002577/1 EP/L002191/1 MERG-CT-2007-207292 no. 692335 VEGA 1/0489/21 APVV-19-0386 PD/00193/2012 UID/FIS/00068/2020 UID/Multi/04378/2020Experiments on neutral gas-phase nucleosides are often complicated by thermal lability. Previous mass spectrometry studies of nucleosides have identified enhanced relative production of nucleobase ions (e.g.uracil+from uridine) as a function of desorption temperature to be the critical indicator of thermal decomposition. On this basis, the present multi-photon ionization (MPI) experiments demonstrate that laser-based thermal desorption is effective for producing uridine, 5-methyluridine, and 2′-deoxyuridine targets without thermal decomposition. Our experiments also revealed one notable thermal dependence: the relative production of the sugar ion C5H9O4+from intact uridine increased substantially with the desorption laser power and this only occurred at MPI wavelengths below 250 nm (full range studied 222-265 nm). We argue that this effect can only be rationalized plausibly in terms of changing populations of different isomers, tautomers, or conformers in the target as a function of the thermal desorption conditions. Furthermore, the wavelength threshold behavior of this thermally-sensitive MPI channel indicates a critical dependence on neutral excited state dynamics between the absorption of the first and second photons. The experimental results are complemented by density functional theory (DFT) optimizations of the lowest-energy structure of uridine and two further conformers distinguished by different orientations of the hydroxymethyl group on the sugar part of the molecule. The energies of the transitions states between these three conformers are low compared with the energy required for decomposition.DF – Departamento de FísicaCeFITec – Centro de Física e Investigação TecnológicaRUNBocková, JanaRebelo, AndréRyszka, MichalPandey, RahulMészáros, D.Limão-Vieira, PauloPapp, P.Mason, Nigel J.Townsend, DaveNixon, K. L.Vizcaino, ViolainePoully, JeanEden, Samuel2022-04-12T22:48:52Z2021-05-092021-05-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/136340eng2046-2069PURE: 43180985https://doi.org/10.1039/d1ra01873finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:30Zoai:run.unl.pt:10362/136340Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:41.937915Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| title |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| spellingShingle |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues Bocková, Jana Chemistry(all) Chemical Engineering(all) |
| title_short |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| title_full |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| title_fullStr |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| title_full_unstemmed |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| title_sort |
Thermal desorption effects on fragment ion production from multi-photon ionized uridine and selected analogues |
| author |
Bocková, Jana |
| author_facet |
Bocková, Jana Rebelo, André Ryszka, Michal Pandey, Rahul Mészáros, D. Limão-Vieira, Paulo Papp, P. Mason, Nigel J. Townsend, Dave Nixon, K. L. Vizcaino, Violaine Poully, Jean Eden, Samuel |
| author_role |
author |
| author2 |
Rebelo, André Ryszka, Michal Pandey, Rahul Mészáros, D. Limão-Vieira, Paulo Papp, P. Mason, Nigel J. Townsend, Dave Nixon, K. L. Vizcaino, Violaine Poully, Jean Eden, Samuel |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DF – Departamento de Física CeFITec – Centro de Física e Investigação Tecnológica RUN |
| dc.contributor.author.fl_str_mv |
Bocková, Jana Rebelo, André Ryszka, Michal Pandey, Rahul Mészáros, D. Limão-Vieira, Paulo Papp, P. Mason, Nigel J. Townsend, Dave Nixon, K. L. Vizcaino, Violaine Poully, Jean Eden, Samuel |
| dc.subject.por.fl_str_mv |
Chemistry(all) Chemical Engineering(all) |
| topic |
Chemistry(all) Chemical Engineering(all) |
| description |
FuEP/E039618/1 EP/J002577/1 EP/L002191/1 MERG-CT-2007-207292 no. 692335 VEGA 1/0489/21 APVV-19-0386 PD/00193/2012 UID/FIS/00068/2020 UID/Multi/04378/2020 |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-05-09 2021-05-09T00:00:00Z 2022-04-12T22:48:52Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/136340 |
| url |
http://hdl.handle.net/10362/136340 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2046-2069 PURE: 43180985 https://doi.org/10.1039/d1ra01873f |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
10 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138087592263680 |