Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence

Detalhes bibliográficos
Autor(a) principal: De Niz, Mariana
Data de Publicação: 2021
Outros Autores: Brás, Daniela, Ouarné, Marie, Pedro, Mafalda, Nascimento, Ana M., Henao Misikova, Lenka, Franco, Claudio A., Figueiredo, Luisa M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/142772
Resumo: LT000047/2019-L ALTF 1048-2016 CEECIND/03322/2108 17CVD03 PRECISE-LISBOA-01-0145-FEDER-016394 CEECIND/04251/2017
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spelling Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulenceendothelial receptorsintravital microscopyparasitestropismTrypanosoma bruceivasculatureBiochemistry, Genetics and Molecular Biology(all)SDG 7 - Affordable and Clean EnergyLT000047/2019-L ALTF 1048-2016 CEECIND/03322/2108 17CVD03 PRECISE-LISBOA-01-0145-FEDER-016394 CEECIND/04251/2017Trypanosoma brucei is responsible for lethal diseases in humans and cattle in Sub-Saharan Africa. These extracellular parasites extravasate from the blood circulation into several tissues. The importance of the vasculature in tissue tropism is poorly understood. Using intravital imaging and bioluminescence, we observe that gonadal white adipose tissue and pancreas are the two main parasite reservoirs. We show that reservoir establishment happens before vascular permeability is compromised, suggesting that extravasation is an active mechanism. Blocking endothelial surface adhesion molecules (E-selectin, P-selectins, or ICAM2) significantly reduces extravascular parasite density in all organs and delays host lethality. Remarkably, blocking CD36 has a specific effect on adipose tissue tropism that is sufficient to delay lethality, suggesting that establishment of the adipose tissue reservoir is necessary for parasite virulence. This work demonstrates the importance of the vasculature in a T. brucei infection and identifies organ-specific adhesion molecules as key players for tissue tropism.DCV - Departamento de Ciências da VidaRUNDe Niz, MarianaBrás, DanielaOuarné, MariePedro, MafaldaNascimento, Ana M.Henao Misikova, LenkaFranco, Claudio A.Figueiredo, Luisa M.2022-08-01T22:26:02Z2021-09-212021-09-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/142772eng2211-1247PURE: 45750164https://doi.org/10.1016/j.celrep.2021.109741info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:20:41Zoai:run.unl.pt:10362/142772Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:30.732733Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
title Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
spellingShingle Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
De Niz, Mariana
endothelial receptors
intravital microscopy
parasites
tropism
Trypanosoma brucei
vasculature
Biochemistry, Genetics and Molecular Biology(all)
SDG 7 - Affordable and Clean Energy
title_short Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
title_full Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
title_fullStr Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
title_full_unstemmed Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
title_sort Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
author De Niz, Mariana
author_facet De Niz, Mariana
Brás, Daniela
Ouarné, Marie
Pedro, Mafalda
Nascimento, Ana M.
Henao Misikova, Lenka
Franco, Claudio A.
Figueiredo, Luisa M.
author_role author
author2 Brás, Daniela
Ouarné, Marie
Pedro, Mafalda
Nascimento, Ana M.
Henao Misikova, Lenka
Franco, Claudio A.
Figueiredo, Luisa M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv De Niz, Mariana
Brás, Daniela
Ouarné, Marie
Pedro, Mafalda
Nascimento, Ana M.
Henao Misikova, Lenka
Franco, Claudio A.
Figueiredo, Luisa M.
dc.subject.por.fl_str_mv endothelial receptors
intravital microscopy
parasites
tropism
Trypanosoma brucei
vasculature
Biochemistry, Genetics and Molecular Biology(all)
SDG 7 - Affordable and Clean Energy
topic endothelial receptors
intravital microscopy
parasites
tropism
Trypanosoma brucei
vasculature
Biochemistry, Genetics and Molecular Biology(all)
SDG 7 - Affordable and Clean Energy
description LT000047/2019-L ALTF 1048-2016 CEECIND/03322/2108 17CVD03 PRECISE-LISBOA-01-0145-FEDER-016394 CEECIND/04251/2017
publishDate 2021
dc.date.none.fl_str_mv 2021-09-21
2021-09-21T00:00:00Z
2022-08-01T22:26:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142772
url http://hdl.handle.net/10362/142772
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2211-1247
PURE: 45750164
https://doi.org/10.1016/j.celrep.2021.109741
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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