CA-125 AUC as a new prognostic factor for patients with ovarian cancer

Detalhes bibliográficos
Autor(a) principal: Mano, Antonio
Data de Publicação: 2005
Outros Autores: Falcão, Amílcar, Godinho, I., Santos, J., Leitão, F., Oliveira, C., Caramona, M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/275
https://doi.org/10.1016/j.ygyno.2005.01.040
Resumo: Prémio atribuído pelo International Research Promotion Council a Amílcar C. Falcão: Eminent Scientist of the Year 2006. Europe
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spelling CA-125 AUC as a new prognostic factor for patients with ovarian cancerneoplasias do ovarioprognosticomarcadores tumoraisfarmacocinéticaCA 125Prémio atribuído pelo International Research Promotion Council a Amílcar C. Falcão: Eminent Scientist of the Year 2006. EuropeAbstract Objective The aim of the present study was to investigate the usefulness of the CA-125 area under the curve (AUC) as a new kinetic parameter for predicting overall survival in patients with ovarian cancer. In addition, the relationship of CA-125 AUC with other prognostic factors of ovarian cancer was evaluated. Methods Ninety-two patients that underwent primary line chemotherapy within 4 months after submission to cytoreductive surgery were included. For each patient, CA-125 AUC was calculated and a statistical analysis was conducted to compare CA-125 AUC behavior among patients according to several covariates. Results The mean age at diagnostic time was found to be 55.5 (16.1–82.4) years with a mean survival of 39.2 (3.5–100.1; SE = 2.6) months. Across FIGO stage I, II, III, and IV patients had a mean CA-125 AUC of 18.2, 24.6, 147.8, and 574.6 IU/ml*days, respectively (P < 0.05). At the evaluation date, living patients had a mean CA-125 AUC of 40.1 in contrast to 234.1 IU/ml*days (P < 0.05) for deceased ones. Patients with a complete response to primary chemotherapy had a mean CA-125 AUC of 48.8, while patients with a partial response had a mean of 251.7 IU/ml*days, and patients with no response or disease progression had a mean of 316.5 IU/ml*days (P < 0.05). The best CA-125 AUC performance is in predicting patient complete response to chemotherapy with a cut-off of 100 IU/ml*days and an accuracy of 82%. Conclusions Despite CA-125 AUC high correlation with the FIGO stage, residual disease, and patient final outcome, the main interest of CA-125 AUC calculation is to evaluate the treatment efficacy and to foresee a full chemotherapy response. Further studies should be carried out before extrapolating these results to other data sets.Elsevier2005-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/275http://hdl.handle.net/10316/275https://doi.org/10.1016/j.ygyno.2005.01.040engGynecologic Oncology 97:2 (2005) 529-5340090-8258Mano, AntonioFalcão, AmílcarGodinho, I.Santos, J.Leitão, F.Oliveira, C.Caramona, M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:59:26Zoai:estudogeral.uc.pt:10316/275Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:20.018182Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv CA-125 AUC as a new prognostic factor for patients with ovarian cancer
title CA-125 AUC as a new prognostic factor for patients with ovarian cancer
spellingShingle CA-125 AUC as a new prognostic factor for patients with ovarian cancer
Mano, Antonio
neoplasias do ovario
prognostico
marcadores tumorais
farmacocinética
CA 125
title_short CA-125 AUC as a new prognostic factor for patients with ovarian cancer
title_full CA-125 AUC as a new prognostic factor for patients with ovarian cancer
title_fullStr CA-125 AUC as a new prognostic factor for patients with ovarian cancer
title_full_unstemmed CA-125 AUC as a new prognostic factor for patients with ovarian cancer
title_sort CA-125 AUC as a new prognostic factor for patients with ovarian cancer
author Mano, Antonio
author_facet Mano, Antonio
Falcão, Amílcar
Godinho, I.
Santos, J.
Leitão, F.
Oliveira, C.
Caramona, M.
author_role author
author2 Falcão, Amílcar
Godinho, I.
Santos, J.
Leitão, F.
Oliveira, C.
Caramona, M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mano, Antonio
Falcão, Amílcar
Godinho, I.
Santos, J.
Leitão, F.
Oliveira, C.
Caramona, M.
dc.subject.por.fl_str_mv neoplasias do ovario
prognostico
marcadores tumorais
farmacocinética
CA 125
topic neoplasias do ovario
prognostico
marcadores tumorais
farmacocinética
CA 125
description Prémio atribuído pelo International Research Promotion Council a Amílcar C. Falcão: Eminent Scientist of the Year 2006. Europe
publishDate 2005
dc.date.none.fl_str_mv 2005-05
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/275
http://hdl.handle.net/10316/275
https://doi.org/10.1016/j.ygyno.2005.01.040
url http://hdl.handle.net/10316/275
https://doi.org/10.1016/j.ygyno.2005.01.040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gynecologic Oncology 97:2 (2005) 529-534
0090-8258
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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