PERSYVE - Design and validation of a questionnaire about adverse effects of antihypertensive drugs

• Autor(a) principal: Duarte-Silva, Daniela
• Data de Publicação: 2014
• Outros Autores: Figueiras, Adolfo, Herdeiro, Maria Teresa, Teixeira Rodrigues, António, Branco, Fábio Silva, Polónia, Jorge, Figueiredo, Isabel V.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/109519; https://doi.org/10.4321/s1886-36552014000200005
• topic: Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions; Medication Adherence; Questionnaires; Validation Studies as Topic; Portugal; Antihipertensivos; Efectos colaterales de y reacciones adversas de los medicamentos;; Cumplimiento de la Medicación; Cuestionarios; Estudios de Validación como Asunto; Portugal

Objective: The aim of this study was to design and validate a questionnaire to measure perceived symptoms associated with antihypertensive drugs (PERSYVE). Methods: The PERSYVE development and validation included four stages: 1) item development (bibliographic review and questionnaire elaboration); 2) face and content validation; 3) field testing (pre-test); and 4) test-retest validation, assessment of internal consistency (Cronbach’s alpha) and reproducibility over time (intraclass correlation coefficient and Cohen’s kappa coefficient). Results: PERSYVE is divided into six sections according to results obtained from the literature review: (1) drug adherence, (2) perceived symptoms and how they affect quality of life (five-point Likert scale), (3) communication with health professionals, (4) perception of symptoms as adverse reactions, (5) influence on therapy compliance, and (6) adoption of non-pharmacological methods for blood pressure control. Content and face validation of the questionnaire led to some vocabulary changes and the introduction of section 2.1. Field-testing (n=26) revealed high comprehensibility of the questions. The Cronbach's alpha, calculated for section 2 (five-point Likert scale) was 0.850. PERSYVE was reproducible (n=167): kappa values presented fair to substantial reproducibility and, in section 2, ICC values resulted in good to excellent reproducibility. Conclusion: Results showed that PERSYVE is a wellstructured, objective, patient-friendly, valid and reliable questionnaire. PERSYVE can be a very useful instrument in hypertensive patients’ monitoring and in the screening of adverse effects.