Wound-healing potentiation in mice treated with phenolic extracts of Moringa oleifera leaves planted at different climatic areas

• Autor(a) principal: Benkiran, Sara
• Data de Publicação: 2024
• Outros Autores: Zinedine, Abdellah, Aziz, Tariq, Rocha, João Miguel, Ayam, Iman Msegued, Raoui, Sidi Mohammed, Chabir, Rachida, Errachidi, Faouzi, Alharbi, Metab, Albekairi, Thamer H., Alasmari, Abdullah F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.14/44008
• topic: Moringa oleifera; Aqueous extract; Ethanolic extract; Mice; Phenolic compounds; Wound-healing potentiation

For years, Moringa oleifera has been known for possessing wound-healing properties. This study aimed to investigate the effect of two extracts: aqueous extract (AE) and ethanolic extract (EE) of Moringa oleifera leaves planted at two regions (Mssisi and Lamta) in Morocco for their anti-inflammatory and healing properties, for which mice were used as a biological model. Inflammation was monitored by assessing forepaw volume of mice, measured at 0 min, 1 h, 3 h, and 5 h, after its induction by carrageenan. Hind paw of mice were treated with extracts of M. oleifera, at a dose of 50 mg/kg, obtained from Mssisi region. This resulted in reduction of edema by 99.2% with EE and by 91.8% with AE, compared to controls and the phenolic extract of M. oleifera planted at Lamta region. Regarding healing of burns induced on rat’s dorsal region; results showed that application of Moringa-based ointment for 14 days, at a dose of 50 mg/kg on wounds, resulted in total healing, compared to controls (negative control: more than 22 days, and positive control: 22 days). M. oleifera extracts resulted in nearly complete tissue repair of 98.26% and 95.34% with EE and AE, respectively.