Thrombocytopenia and platelet transfusions in ICU patients
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/160035 |
Resumo: | © 2023. The Author(s). |
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Thrombocytopenia and platelet transfusions in ICU patientsan international inception cohort study (PLOT-ICU)BleedingCritical illnessIntensive care unitPlatelet transfusionThrombocytopeniaThrombosisSDG 3 - Good Health and Well-being© 2023. The Author(s).PURPOSE: Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses. RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42). CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNAnthon, Carl ThomasPène, FrédéricPerner, AndersAzoulay, EliePuxty, KathrynVan De Louw, AndryBarratt-Due, AndreasChawla, SanjayCastro, PedroPóvoa, PedroCoelho, LuisMetaxa, VictoriaKochanek, MatthiasLiebregts, TobiasKander, ThomasHästbacka, JohannaAndreasen, Jo BøndingPéju, EdwigeNielsen, Lene BjerregaardHvas, Christine LodbergDufranc, EtienneCanet, EmmanuelLundqvist, LindaWright, Christopher JohnSchmidt, JulienUhel, FabriceAit-Oufella, HafidKrag, MetteCos Badia, ElisabetDíaz-Lagares, CándidoMenat, SophieVoiriot, GuillaumeClausen, Niels ErikstrupLorentzen, KristianKvåle, ReidarHildebrandt, ThomasHolten, Aleksander RyghStrand, KristianTzalavras, AsteriosBestle, Morten HeibergKlepstad, PålFernandez, SaraVimpere, DamienPaulino, CarolinaGraça, CarinaLueck, CatherinaJuhl, Christian SvendsenCosta, CarolinaBådstøløkken, Per MartinMiranda, Teresa2023-11-16T22:09:09Z2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160035eng0342-4642PURE: 74231056https://doi.org/10.1007/s00134-023-07225-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:33Zoai:run.unl.pt:10362/160035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:49.382193Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Thrombocytopenia and platelet transfusions in ICU patients an international inception cohort study (PLOT-ICU) |
| title |
Thrombocytopenia and platelet transfusions in ICU patients |
| spellingShingle |
Thrombocytopenia and platelet transfusions in ICU patients Anthon, Carl Thomas Bleeding Critical illness Intensive care unit Platelet transfusion Thrombocytopenia Thrombosis SDG 3 - Good Health and Well-being |
| title_short |
Thrombocytopenia and platelet transfusions in ICU patients |
| title_full |
Thrombocytopenia and platelet transfusions in ICU patients |
| title_fullStr |
Thrombocytopenia and platelet transfusions in ICU patients |
| title_full_unstemmed |
Thrombocytopenia and platelet transfusions in ICU patients |
| title_sort |
Thrombocytopenia and platelet transfusions in ICU patients |
| author |
Anthon, Carl Thomas |
| author_facet |
Anthon, Carl Thomas Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Barratt-Due, Andreas Chawla, Sanjay Castro, Pedro Póvoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Hästbacka, Johanna Andreasen, Jo Bønding Péju, Edwige Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Lundqvist, Linda Wright, Christopher John Schmidt, Julien Uhel, Fabrice Ait-Oufella, Hafid Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Clausen, Niels Erikstrup Lorentzen, Kristian Kvåle, Reidar Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Tzalavras, Asterios Bestle, Morten Heiberg Klepstad, Pål Fernandez, Sara Vimpere, Damien Paulino, Carolina Graça, Carina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Miranda, Teresa |
| author_role |
author |
| author2 |
Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Barratt-Due, Andreas Chawla, Sanjay Castro, Pedro Póvoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Hästbacka, Johanna Andreasen, Jo Bønding Péju, Edwige Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Lundqvist, Linda Wright, Christopher John Schmidt, Julien Uhel, Fabrice Ait-Oufella, Hafid Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Clausen, Niels Erikstrup Lorentzen, Kristian Kvåle, Reidar Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Tzalavras, Asterios Bestle, Morten Heiberg Klepstad, Pål Fernandez, Sara Vimpere, Damien Paulino, Carolina Graça, Carina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Miranda, Teresa |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Anthon, Carl Thomas Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Barratt-Due, Andreas Chawla, Sanjay Castro, Pedro Póvoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Hästbacka, Johanna Andreasen, Jo Bønding Péju, Edwige Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Lundqvist, Linda Wright, Christopher John Schmidt, Julien Uhel, Fabrice Ait-Oufella, Hafid Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Clausen, Niels Erikstrup Lorentzen, Kristian Kvåle, Reidar Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Tzalavras, Asterios Bestle, Morten Heiberg Klepstad, Pål Fernandez, Sara Vimpere, Damien Paulino, Carolina Graça, Carina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Miranda, Teresa |
| dc.subject.por.fl_str_mv |
Bleeding Critical illness Intensive care unit Platelet transfusion Thrombocytopenia Thrombosis SDG 3 - Good Health and Well-being |
| topic |
Bleeding Critical illness Intensive care unit Platelet transfusion Thrombocytopenia Thrombosis SDG 3 - Good Health and Well-being |
| description |
© 2023. The Author(s). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-16T22:09:09Z 2023-11 2023-11-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/160035 |
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http://hdl.handle.net/10362/160035 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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0342-4642 PURE: 74231056 https://doi.org/10.1007/s00134-023-07225-2 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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