The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/69680 |
Resumo: | This systematic review explored the neurobiological mechanisms underlying the clinical time course of cancer-related cognitive impairment (CRCI) in breast cancer patients through the review of longitudinal neuroimaging studies. Before chemotherapy, results reported no evidence for neuropsychological, structural (gray matter) and brain perfusion changes. However, functional brain alterations were evident and revealed a frontoparietal hyperactivation during working memory tasks. Fatigue and number of days since surgery were the two suggested confounding factors. Acutely after chemotherapy, this review found no evidence for neuropsychological changes while suggesting a pattern of frontal structural, perfusion and functional brain abnormalities. These findings seemed to be dependent on age, menopausal status at baseline, and fMRI task performed. Years after chemotherapy, results revealed evidence of partial neuropsychological, structural, and functional brain recovery. Regarding brain abnormality, this review suggested that it may begin quite early in the disease course, be more prominent shortly after chemotherapy and partially recover over time. Several hypotheses underlying these changes were discussed. The present review also provided important information for developing a time-specific treatment and prevention strategies and for the consideration of functional neuroimaging as a relevant tool for CRCI diagnosis, clinical monitoring, and intervention studies. The findings also suggested the need to implement studies with longitudinal designs, including a pre-treatment assessment, since cross-sectional studies were not able to detect this pattern of recovery over time, supporting only the theory of brain abnormalities, in breast cancer survivors. |
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The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studiesBreast cancerCognitionCancer-related cognitive impairmentNeuroimagingMRIfMRICiências Sociais::PsicologiaSocial SciencesScience & TechnologySaúde de qualidadeThis systematic review explored the neurobiological mechanisms underlying the clinical time course of cancer-related cognitive impairment (CRCI) in breast cancer patients through the review of longitudinal neuroimaging studies. Before chemotherapy, results reported no evidence for neuropsychological, structural (gray matter) and brain perfusion changes. However, functional brain alterations were evident and revealed a frontoparietal hyperactivation during working memory tasks. Fatigue and number of days since surgery were the two suggested confounding factors. Acutely after chemotherapy, this review found no evidence for neuropsychological changes while suggesting a pattern of frontal structural, perfusion and functional brain abnormalities. These findings seemed to be dependent on age, menopausal status at baseline, and fMRI task performed. Years after chemotherapy, results revealed evidence of partial neuropsychological, structural, and functional brain recovery. Regarding brain abnormality, this review suggested that it may begin quite early in the disease course, be more prominent shortly after chemotherapy and partially recover over time. Several hypotheses underlying these changes were discussed. The present review also provided important information for developing a time-specific treatment and prevention strategies and for the consideration of functional neuroimaging as a relevant tool for CRCI diagnosis, clinical monitoring, and intervention studies. The findings also suggested the need to implement studies with longitudinal designs, including a pre-treatment assessment, since cross-sectional studies were not able to detect this pattern of recovery over time, supporting only the theory of brain abnormalities, in breast cancer survivors.SpringerUniversidade do MinhoSousa, HelenaAlmeida, SusanaPeixoto, João Miguel Seiça BessaPereira, M. Graça2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/69680engSousa, H., Almeida, S., Bessa, J., & Pereira, M. G. (2020). The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies. Neuropsychology Review, 1-231040-73081573-666010.1007/s11065-020-09441-932607817https://link.springer.com/article/10.1007/s11065-020-09441-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-07T01:20:30Zoai:repositorium.sdum.uminho.pt:1822/69680Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:54:54.959324Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
title |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
spellingShingle |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies Sousa, Helena Breast cancer Cognition Cancer-related cognitive impairment Neuroimaging MRI fMRI Ciências Sociais::Psicologia Social Sciences Science & Technology Saúde de qualidade |
title_short |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
title_full |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
title_fullStr |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
title_full_unstemmed |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
title_sort |
The developmental trajectory of cancer-related cognitive impairment in breast cancer patients: a systematic review of longitudinal neuroimaging studies |
author |
Sousa, Helena |
author_facet |
Sousa, Helena Almeida, Susana Peixoto, João Miguel Seiça Bessa Pereira, M. Graça |
author_role |
author |
author2 |
Almeida, Susana Peixoto, João Miguel Seiça Bessa Pereira, M. Graça |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sousa, Helena Almeida, Susana Peixoto, João Miguel Seiça Bessa Pereira, M. Graça |
dc.subject.por.fl_str_mv |
Breast cancer Cognition Cancer-related cognitive impairment Neuroimaging MRI fMRI Ciências Sociais::Psicologia Social Sciences Science & Technology Saúde de qualidade |
topic |
Breast cancer Cognition Cancer-related cognitive impairment Neuroimaging MRI fMRI Ciências Sociais::Psicologia Social Sciences Science & Technology Saúde de qualidade |
description |
This systematic review explored the neurobiological mechanisms underlying the clinical time course of cancer-related cognitive impairment (CRCI) in breast cancer patients through the review of longitudinal neuroimaging studies. Before chemotherapy, results reported no evidence for neuropsychological, structural (gray matter) and brain perfusion changes. However, functional brain alterations were evident and revealed a frontoparietal hyperactivation during working memory tasks. Fatigue and number of days since surgery were the two suggested confounding factors. Acutely after chemotherapy, this review found no evidence for neuropsychological changes while suggesting a pattern of frontal structural, perfusion and functional brain abnormalities. These findings seemed to be dependent on age, menopausal status at baseline, and fMRI task performed. Years after chemotherapy, results revealed evidence of partial neuropsychological, structural, and functional brain recovery. Regarding brain abnormality, this review suggested that it may begin quite early in the disease course, be more prominent shortly after chemotherapy and partially recover over time. Several hypotheses underlying these changes were discussed. The present review also provided important information for developing a time-specific treatment and prevention strategies and for the consideration of functional neuroimaging as a relevant tool for CRCI diagnosis, clinical monitoring, and intervention studies. The findings also suggested the need to implement studies with longitudinal designs, including a pre-treatment assessment, since cross-sectional studies were not able to detect this pattern of recovery over time, supporting only the theory of brain abnormalities, in breast cancer survivors. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06 2020-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/69680 |
url |
https://hdl.handle.net/1822/69680 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sousa, H., Almeida, S., Bessa, J., & Pereira, M. G. (2020). The Developmental Trajectory of Cancer-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review of Longitudinal Neuroimaging Studies. Neuropsychology Review, 1-23 1040-7308 1573-6660 10.1007/s11065-020-09441-9 32607817 https://link.springer.com/article/10.1007/s11065-020-09441-9 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132333146636288 |