Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

Detalhes bibliográficos
Autor(a) principal: Cristofaro, Brunella
Data de Publicação: 2013
Outros Autores: Yu Shi, Faria, Marcella, Suchting, Steven, Leroyer, Aurelie S., Trindade, Alexandre, Duarte, Antonio, Zovein, Ann C., Iruela-Arispe, M. Luisa, Nih, Lina R., Kubis, Nathalie, Henrion, Daniel, Loufrani, Laurent, Todiras, Mihail, Schleifenbaum, Johanna, Gollasch, Maik, Zhuang, Zhen W., Simons, Michael, Eichmann, Anne, Le Noble, Ferdinand
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/7132
Resumo: Articles in International Journals
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spelling Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia modelsAngiogenesisArteriogenesisVessel branchingDll4-Notch signalingMouseArticles in International JournalsArteriogenesis requires growth of pre-existing arteriolar collateral networks and determines clinical outcome in arterial occlusive diseases. Factors responsible for the development of arteriolar collateral networks are poorly understood. The Notch ligand Deltalike 4 (Dll4) promotes arterial differentiation and restricts vessel branching. We hypothesized that Dll4 may act as a genetic determinant of collateral arterial networks and functional recovery in stroke and hind limb ischemia models in mice. Genetic lossand gain-of-function approaches in mice showed that Dll4-Notch signaling restricts pial collateral artery formation by modulating arterial branching morphogenesis during embryogenesis. Adult Dll4+/− mice showed increased pial collateral numbers, but stroke volume upon middle cerebral artery occlusion was not reduced compared with wild-type littermates. Likewise, Dll4+/− mice showed reduced blood flow conductance after femoral artery occlusion, and, despite markedly increased angiogenesis, tissue ischemia was more severe. In peripheral arteries, loss of Dll4 adversely affected excitation-contraction coupling in arterial smooth muscle in response to vasopressor agents and arterial vessel wall adaption in response to increases in blood flow, collectively contributing to reduced flow reserve. We conclude that Dll4-Notch signaling modulates native collateral formation by acting on vascular branching morphogenesis during embryogenesis. Dll4 furthermore affects tissue perfusion by acting on arterial function and structure. Loss of Dll4 stimulates collateral formation and angiogenesis, but in the context of ischemic diseases such beneficial effects are overruled by adverse functional changes, demonstrating that ischemic recovery is not solely determined by collateral number but rather by vessel functionality.The Company of Biologists LtdRepositório da Universidade de LisboaCristofaro, BrunellaYu ShiFaria, MarcellaSuchting, StevenLeroyer, Aurelie S.Trindade, AlexandreDuarte, AntonioZovein, Ann C.Iruela-Arispe, M. LuisaNih, Lina R.Kubis, NathalieHenrion, DanielLoufrani, LaurentTodiras, MihailSchleifenbaum, JohannaGollasch, MaikZhuang, Zhen W.Simons, MichaelEichmann, AnneLe Noble, Ferdinand2014-09-10T11:36:42Z2013-04-152013-04-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7132engCristofaro, B., (2013). Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development, 140(8), 1720-1729. doi:10.1242/dev.0923041477-912910.1242/dev.092304info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:37:53Zoai:www.repository.utl.pt:10400.5/7132Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:54:20.044774Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
title Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
spellingShingle Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
Cristofaro, Brunella
Angiogenesis
Arteriogenesis
Vessel branching
Dll4-Notch signaling
Mouse
title_short Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
title_full Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
title_fullStr Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
title_full_unstemmed Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
title_sort Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models
author Cristofaro, Brunella
author_facet Cristofaro, Brunella
Yu Shi
Faria, Marcella
Suchting, Steven
Leroyer, Aurelie S.
Trindade, Alexandre
Duarte, Antonio
Zovein, Ann C.
Iruela-Arispe, M. Luisa
Nih, Lina R.
Kubis, Nathalie
Henrion, Daniel
Loufrani, Laurent
Todiras, Mihail
Schleifenbaum, Johanna
Gollasch, Maik
Zhuang, Zhen W.
Simons, Michael
Eichmann, Anne
Le Noble, Ferdinand
author_role author
author2 Yu Shi
Faria, Marcella
Suchting, Steven
Leroyer, Aurelie S.
Trindade, Alexandre
Duarte, Antonio
Zovein, Ann C.
Iruela-Arispe, M. Luisa
Nih, Lina R.
Kubis, Nathalie
Henrion, Daniel
Loufrani, Laurent
Todiras, Mihail
Schleifenbaum, Johanna
Gollasch, Maik
Zhuang, Zhen W.
Simons, Michael
Eichmann, Anne
Le Noble, Ferdinand
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cristofaro, Brunella
Yu Shi
Faria, Marcella
Suchting, Steven
Leroyer, Aurelie S.
Trindade, Alexandre
Duarte, Antonio
Zovein, Ann C.
Iruela-Arispe, M. Luisa
Nih, Lina R.
Kubis, Nathalie
Henrion, Daniel
Loufrani, Laurent
Todiras, Mihail
Schleifenbaum, Johanna
Gollasch, Maik
Zhuang, Zhen W.
Simons, Michael
Eichmann, Anne
Le Noble, Ferdinand
dc.subject.por.fl_str_mv Angiogenesis
Arteriogenesis
Vessel branching
Dll4-Notch signaling
Mouse
topic Angiogenesis
Arteriogenesis
Vessel branching
Dll4-Notch signaling
Mouse
description Articles in International Journals
publishDate 2013
dc.date.none.fl_str_mv 2013-04-15
2013-04-15T00:00:00Z
2014-09-10T11:36:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/7132
url http://hdl.handle.net/10400.5/7132
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cristofaro, B., (2013). Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development, 140(8), 1720-1729. doi:10.1242/dev.092304
1477-9129
10.1242/dev.092304
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Company of Biologists Ltd
publisher.none.fl_str_mv The Company of Biologists Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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