Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/1858 |
Resumo: | BACKGROUND AND AIMS: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument. METHODS: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire. RESULTS: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70). CONCLUSION: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis. |
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Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence countryGastrointestinal endoscopyQoLgastric cancerintestinal metaplasiaatrophic gastritisBACKGROUND AND AIMS: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument. METHODS: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire. RESULTS: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70). CONCLUSION: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis.Medical University Press Cluj, RomaniaRepositório Científico do Centro Hospitalar Universitário de Santo AntónioAreia, M.Alves, S.Brito, D.Cadime, A.Carvalho, R.Saraiva, S.Ferreira, S.Moleiro, J.Pereira, A.Carrasquinho, J.Lopes, L.Ramada, J.Marcos-Pinto, R.Pedroto, I.Contente, L.Eliseu, L.Vieira, A.Sampaio, M.Sousa, H.Almeida, N.Gregório, C.Portela, F.Sofia, C.Braga, V.Baginha, E.Bana e Costa, T.Chagas, C.Mendes, L.Magalhães-Costa, P.Matos, L.Gonçalves, F.Dinis-Ribeiro, M.2015-10-12T11:40:57Z2014-122014-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1858engJ Gastrointestin Liver Dis, December 2014 Vol. 23(4): 371-378http://dx.doi.org/10.15403/jgld.2014.1121.234.hrqinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:57:52Zoai:repositorio.chporto.pt:10400.16/1858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:11.046620Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
title |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
spellingShingle |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country Areia, M. Gastrointestinal endoscopy QoL gastric cancer intestinal metaplasia atrophic gastritis |
title_short |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
title_full |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
title_fullStr |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
title_full_unstemmed |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
title_sort |
Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country |
author |
Areia, M. |
author_facet |
Areia, M. Alves, S. Brito, D. Cadime, A. Carvalho, R. Saraiva, S. Ferreira, S. Moleiro, J. Pereira, A. Carrasquinho, J. Lopes, L. Ramada, J. Marcos-Pinto, R. Pedroto, I. Contente, L. Eliseu, L. Vieira, A. Sampaio, M. Sousa, H. Almeida, N. Gregório, C. Portela, F. Sofia, C. Braga, V. Baginha, E. Bana e Costa, T. Chagas, C. Mendes, L. Magalhães-Costa, P. Matos, L. Gonçalves, F. Dinis-Ribeiro, M. |
author_role |
author |
author2 |
Alves, S. Brito, D. Cadime, A. Carvalho, R. Saraiva, S. Ferreira, S. Moleiro, J. Pereira, A. Carrasquinho, J. Lopes, L. Ramada, J. Marcos-Pinto, R. Pedroto, I. Contente, L. Eliseu, L. Vieira, A. Sampaio, M. Sousa, H. Almeida, N. Gregório, C. Portela, F. Sofia, C. Braga, V. Baginha, E. Bana e Costa, T. Chagas, C. Mendes, L. Magalhães-Costa, P. Matos, L. Gonçalves, F. Dinis-Ribeiro, M. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Areia, M. Alves, S. Brito, D. Cadime, A. Carvalho, R. Saraiva, S. Ferreira, S. Moleiro, J. Pereira, A. Carrasquinho, J. Lopes, L. Ramada, J. Marcos-Pinto, R. Pedroto, I. Contente, L. Eliseu, L. Vieira, A. Sampaio, M. Sousa, H. Almeida, N. Gregório, C. Portela, F. Sofia, C. Braga, V. Baginha, E. Bana e Costa, T. Chagas, C. Mendes, L. Magalhães-Costa, P. Matos, L. Gonçalves, F. Dinis-Ribeiro, M. |
dc.subject.por.fl_str_mv |
Gastrointestinal endoscopy QoL gastric cancer intestinal metaplasia atrophic gastritis |
topic |
Gastrointestinal endoscopy QoL gastric cancer intestinal metaplasia atrophic gastritis |
description |
BACKGROUND AND AIMS: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument. METHODS: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire. RESULTS: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70). CONCLUSION: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12 2014-12-01T00:00:00Z 2015-10-12T11:40:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/1858 |
url |
http://hdl.handle.net/10400.16/1858 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Gastrointestin Liver Dis, December 2014 Vol. 23(4): 371-378 http://dx.doi.org/10.15403/jgld.2014.1121.234.hrq |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Medical University Press Cluj, Romania |
publisher.none.fl_str_mv |
Medical University Press Cluj, Romania |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133643384291328 |