Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications

Detalhes bibliográficos
Autor(a) principal: Spínola, Vítor
Data de Publicação: 2018
Outros Autores: Castilho, Paula C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.13/3205
Resumo: The qualitative and quantitative characterization of Madeira moneywort (Sibthorpia peregrina L.) compounds was investigated for the first time. The antioxidant activity and the effect of the methanolic extract on digestive enzymes activity linked to type-2 diabetes and obesity were also determined by in vitro assays. A total of 56 components were characterized in S. peregrina. Phenylethanoids glycosides (PhEGs) represented the main classes of compounds (95.23 mg g-1 of dry extract), almost all verbascoside and its derivatives (up to 98.85% of the total individual phenolic content). The analysed sample was active against ABTS, DPPH, nitric oxide and superoxide radicals, suggesting a potential beneficial effect against oxidative stress. In addition, the methanolic extract was able to inhibit the catalytic activity of α-, β-glucosidases, α-amylase and pancreatic lipase. Overall, S. peregrina showed good perspectives to be explored as a rich source of verbascoside and its derivatives for nutraceutical/pharmaceutical products.
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spelling Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applicationsSibthorbia peregrina L.Madeira moneyworPhenolic compositionVerbascosideAntioxidant activityDigestive enzymes inhibition.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da MadeiraThe qualitative and quantitative characterization of Madeira moneywort (Sibthorpia peregrina L.) compounds was investigated for the first time. The antioxidant activity and the effect of the methanolic extract on digestive enzymes activity linked to type-2 diabetes and obesity were also determined by in vitro assays. A total of 56 components were characterized in S. peregrina. Phenylethanoids glycosides (PhEGs) represented the main classes of compounds (95.23 mg g-1 of dry extract), almost all verbascoside and its derivatives (up to 98.85% of the total individual phenolic content). The analysed sample was active against ABTS, DPPH, nitric oxide and superoxide radicals, suggesting a potential beneficial effect against oxidative stress. In addition, the methanolic extract was able to inhibit the catalytic activity of α-, β-glucosidases, α-amylase and pancreatic lipase. Overall, S. peregrina showed good perspectives to be explored as a rich source of verbascoside and its derivatives for nutraceutical/pharmaceutical products.This work was supported by Fundação para a Ciência e a Tecnologia (FCT, Portugal) [grant number SFRH/ BD/84672/2012] with funds from the Portuguese Government (Project PEst-OE/QUI/UI0674/2013) and the Portuguese National Mass Spectrometry Network (Contract RNEMREDE/1508/REM/2005). Funding through the project M1420-01-0145-FEDER-000005 – Centro de Química da Madeira – CQM+(Madeira 14-20).Taylor and FrancisDigitUMaSpínola, VítorCastilho, Paula C.2021-03-25T15:57:37Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/3205engSpínola, V., & Castilho, P. C. (2019). Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications. Natural product research, 33(22), 3321-3325. 10.1080/14786419.2018.147435410.1080/14786419.2018.1474354info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-10T06:27:02Zoai:digituma.uma.pt:10400.13/3205Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:09.509982Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
title Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
spellingShingle Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
Spínola, Vítor
Sibthorbia peregrina L.
Madeira moneywor
Phenolic composition
Verbascoside
Antioxidant activity
Digestive enzymes inhibition
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
title_short Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
title_full Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
title_fullStr Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
title_full_unstemmed Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
title_sort Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications
author Spínola, Vítor
author_facet Spínola, Vítor
Castilho, Paula C.
author_role author
author2 Castilho, Paula C.
author2_role author
dc.contributor.none.fl_str_mv DigitUMa
dc.contributor.author.fl_str_mv Spínola, Vítor
Castilho, Paula C.
dc.subject.por.fl_str_mv Sibthorbia peregrina L.
Madeira moneywor
Phenolic composition
Verbascoside
Antioxidant activity
Digestive enzymes inhibition
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
topic Sibthorbia peregrina L.
Madeira moneywor
Phenolic composition
Verbascoside
Antioxidant activity
Digestive enzymes inhibition
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
description The qualitative and quantitative characterization of Madeira moneywort (Sibthorpia peregrina L.) compounds was investigated for the first time. The antioxidant activity and the effect of the methanolic extract on digestive enzymes activity linked to type-2 diabetes and obesity were also determined by in vitro assays. A total of 56 components were characterized in S. peregrina. Phenylethanoids glycosides (PhEGs) represented the main classes of compounds (95.23 mg g-1 of dry extract), almost all verbascoside and its derivatives (up to 98.85% of the total individual phenolic content). The analysed sample was active against ABTS, DPPH, nitric oxide and superoxide radicals, suggesting a potential beneficial effect against oxidative stress. In addition, the methanolic extract was able to inhibit the catalytic activity of α-, β-glucosidases, α-amylase and pancreatic lipase. Overall, S. peregrina showed good perspectives to be explored as a rich source of verbascoside and its derivatives for nutraceutical/pharmaceutical products.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-03-25T15:57:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.13/3205
url http://hdl.handle.net/10400.13/3205
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Spínola, V., & Castilho, P. C. (2019). Madeira moneywort (Sibthorpia peregrina L.) as a new source of verbascoside and its derivatives with potential phyto-pharmaceutical applications. Natural product research, 33(22), 3321-3325. 10.1080/14786419.2018.1474354
10.1080/14786419.2018.1474354
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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