The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea

Detalhes bibliográficos
Autor(a) principal: Bikov, Andras
Data de Publicação: 2023
Outros Autores: Bailly, Sebastien, Testelmans, Dries, Fanfulla, Francesco, Pataka, Athanasia, Bouloukaki, Izolde, Hein, Holger, Dogas, Zoran, Basoglu, Ozen K., Staats, Richard, Parati, Gianfranco, Lombardi, Carolina, Grote, Ludger, Mihaicuta, Stefan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/59162
Resumo: © 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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spelling The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apneaApneaCardiovascular diseaseLipidsSleep© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Periodic limb movements during sleep and obstructive sleep apnea are both associated with increased sympathetic tone, and have been proposed as risk factors for heart diseases and, in particular, cardiovascular disease. As sympathetic system activation may lead to dyslipidaemia, periodic limb movements during sleep could be an additional risk factor for cardiovascular disease in patients with obstructive sleep apnea. The aim of the study was to determine whether the presence of periodic limb movements during sleep affects serum lipid levels in obstructive sleep apnea. Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non- high-density lipoprotein cholesterol and triglyceride levels were investigated in 4138 patients with obstructive sleep apnea in the European Sleep Apnea Database (ESADA) cohort, divided into those with periodic limb movements during sleep index ≥ 15 per hr (n = 628) and controls (n = 3510). ANCOVA adjusted for age, sex, body mass index, apnea-hypopnea index, alcohol intake, smoking status, diabetes, insomnia and study site was used to assess differences in lipids between periodic limb movements during sleep and controls. Patients with periodic limb movements during sleep (24% female, 54.4 ± 12.1 years, body mass index 31.9 ± 5.8 kg m-2 , apnea-hypopnea index 36.7 ± 25.4 per hr) had higher triglyceride (1.81 ± 1.04 versus 1.69 ± 0.90 mmol L-1 , p = 0.002) and lower high-density lipoprotein cholesterol (1.19 ± 0.34 versus 1.24 ± 0.37 mmol L-1 , p = 0.002) levels, whilst there was no difference in either total cholesterol (4.98 ± 1.10 versus 4.94 ± 1.07 mmol L-1 ), low-density lipoprotein cholesterol (3.04 ± 0.96 versus 2.98 ± 0.98 mmol L-1 ) or non- high-density lipoprotein cholesterol (3.78 ± 1.10 versus 3.70 ± 1.05 mmol L-1 ) concentrations (all p > 0.05). The results remained unchanged after most sensitivity analyses. Patients with obstructive sleep apnea with periodic limb movements during sleep had more prevalent cardiovascular disease (11% versus 6%, p < 0.01). Periodic limb movements during sleep in obstructive sleep apnea is associated with dyslipidaemia independently of important confounders. Our results highlight periodic limb movements during sleep as an additional risk factor for cardiovascular disease in obstructive sleep apnea.Andras Bikov is supported by the NIHR Manchester BRC. The ESADA network was founded during the COST action B26 supported by the European Union. The ESADA network is one of the Clinical Research Collaborations (CRC) funded by the European Respiratory Society (ERS). Unrestricted seeding grants from the ResMed Foundation and the Philips Respironics Foundation for establishment of the database in 2007 and 2011 are gratefully acknowledged. The ESADA has received an unrestricted grant from Bayer AG for collaborative data analysis. LG and JH are supported by the Swedish Heart and Lung Foundation (20180567 and 20180585) and the agreement concerning research and education of doctors (ALFGBG 725601 and ALFGBG 721521). Support was also provided by the European Sleep Research Society (ESRS) and the ERS in terms of logistics for communication, meetings and data presentations for the ESADA collaborators. SB is supported by the French National Research Agency in the framework of the “Investissements d'avenir” program (ANR-15-IDEX-02) and the “e-health and integrated care and trajectories medicine and MIAI artificial intelligence” (ANR-19-P3IA-0003). The authors thank Mr Andrew Chai for his grammatical corrections.WileyRepositório da Universidade de LisboaBikov, AndrasBailly, SebastienTestelmans, DriesFanfulla, FrancescoPataka, AthanasiaBouloukaki, IzoldeHein, HolgerDogas, ZoranBasoglu, Ozen K.Staats, RichardParati, GianfrancoLombardi, CarolinaGrote, LudgerMihaicuta, Stefan2023-09-07T11:08:39Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59162engJ Sleep Res. 2023 Aug 19;e140120962-110510.1111/jsr.140121365-2869info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:08:08Zoai:repositorio.ul.pt:10451/59162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:07.913494Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
title The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
spellingShingle The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
Bikov, Andras
Apnea
Cardiovascular disease
Lipids
Sleep
title_short The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
title_full The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
title_fullStr The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
title_full_unstemmed The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
title_sort The relationship between periodic limb movement during sleep and dyslipidaemia in patients with obstructive sleep apnea
author Bikov, Andras
author_facet Bikov, Andras
Bailly, Sebastien
Testelmans, Dries
Fanfulla, Francesco
Pataka, Athanasia
Bouloukaki, Izolde
Hein, Holger
Dogas, Zoran
Basoglu, Ozen K.
Staats, Richard
Parati, Gianfranco
Lombardi, Carolina
Grote, Ludger
Mihaicuta, Stefan
author_role author
author2 Bailly, Sebastien
Testelmans, Dries
Fanfulla, Francesco
Pataka, Athanasia
Bouloukaki, Izolde
Hein, Holger
Dogas, Zoran
Basoglu, Ozen K.
Staats, Richard
Parati, Gianfranco
Lombardi, Carolina
Grote, Ludger
Mihaicuta, Stefan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bikov, Andras
Bailly, Sebastien
Testelmans, Dries
Fanfulla, Francesco
Pataka, Athanasia
Bouloukaki, Izolde
Hein, Holger
Dogas, Zoran
Basoglu, Ozen K.
Staats, Richard
Parati, Gianfranco
Lombardi, Carolina
Grote, Ludger
Mihaicuta, Stefan
dc.subject.por.fl_str_mv Apnea
Cardiovascular disease
Lipids
Sleep
topic Apnea
Cardiovascular disease
Lipids
Sleep
description © 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-07T11:08:39Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59162
url http://hdl.handle.net/10451/59162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Sleep Res. 2023 Aug 19;e14012
0962-1105
10.1111/jsr.14012
1365-2869
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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