Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/23786 |
Resumo: | Adequate gestational progression depends to a great extent on placental development, which can modify maternal and neonatal outcomes. Any environmental toxicant, including metals, with the capacity to affect the placenta can alter the development of the pregnancy and its outcome. The objective of this study was to correlate the placenta levels of 14 essential and non-essential elements with neonatal weight. We examined relationships between placental concentrations of arsenic, cadmium, cobalt, copper, mercury, lithium, manganese, molybdenum, nickel, lead, rubidium, selenium, strontium, and zinc from 79 low obstetric risk pregnant women in Ourense (Northwestern Spain, 42°20′12.1″N 7°51.844′O) with neonatal weight. We tested associations between placental metal concentrations and neonatal weight by conducting multivariable linear regressions using generalized linear models (GLM) and generalized additive models (GAM). While placental Co (p = 0.03) and Sr (p = 0.048) concentrations were associated with higher neonatal weight, concentrations of Li (p = 0.027), Mo (p = 0.049), and Se (p = 0.02) in the placenta were associated with lower newborn weight. Our findings suggest that the concentration of some metals in the placenta may affect fetal growth. |
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Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive modelsMetalsPlacentaBirth weightNewborn weightAdequate gestational progression depends to a great extent on placental development, which can modify maternal and neonatal outcomes. Any environmental toxicant, including metals, with the capacity to affect the placenta can alter the development of the pregnancy and its outcome. The objective of this study was to correlate the placenta levels of 14 essential and non-essential elements with neonatal weight. We examined relationships between placental concentrations of arsenic, cadmium, cobalt, copper, mercury, lithium, manganese, molybdenum, nickel, lead, rubidium, selenium, strontium, and zinc from 79 low obstetric risk pregnant women in Ourense (Northwestern Spain, 42°20′12.1″N 7°51.844′O) with neonatal weight. We tested associations between placental metal concentrations and neonatal weight by conducting multivariable linear regressions using generalized linear models (GLM) and generalized additive models (GAM). While placental Co (p = 0.03) and Sr (p = 0.048) concentrations were associated with higher neonatal weight, concentrations of Li (p = 0.027), Mo (p = 0.049), and Se (p = 0.02) in the placenta were associated with lower newborn weight. Our findings suggest that the concentration of some metals in the placenta may affect fetal growth.Springer LinkRepositório Científico do Instituto Politécnico do PortoÁlvarez‑Silvares, Esther Fernández‑Cruz, Tania Bermudez‑González, Mónica Rubio‑Cid, Paula Almeida, Agostinho Pinto, EdgarSeoane‑Pillado, Teresa Martínez‑Carballo, Elena 2023-10-26T15:48:38Z2023-03-212023-03-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23786engÁlvarez-Silvares, E., Fernández-Cruz, T., Bermudez-González, M., Rubio-Cid, P., Almeida, A., Pinto, E., Seoane-Pillado, T., & Martínez-Carballo, E. (2023). Placental levels of essential and non-essential trace element in relation to neonatal weight in Northwestern Spain: Application of generalized additive models. Environmental Science and Pollution Research, 30(22), 62566–62578. https://doi.org/10.1007/s11356-023-26560-x0944-134410.1007/s11356-023-26560-x1614-7499info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-01T01:46:29Zoai:recipp.ipp.pt:10400.22/23786Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:13.521970Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
title |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
spellingShingle |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models Álvarez‑Silvares, Esther Metals Placenta Birth weight Newborn weight |
title_short |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
title_full |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
title_fullStr |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
title_full_unstemmed |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
title_sort |
Placental levels of essential and non‑essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models |
author |
Álvarez‑Silvares, Esther |
author_facet |
Álvarez‑Silvares, Esther Fernández‑Cruz, Tania Bermudez‑González, Mónica Rubio‑Cid, Paula Almeida, Agostinho Pinto, Edgar Seoane‑Pillado, Teresa Martínez‑Carballo, Elena |
author_role |
author |
author2 |
Fernández‑Cruz, Tania Bermudez‑González, Mónica Rubio‑Cid, Paula Almeida, Agostinho Pinto, Edgar Seoane‑Pillado, Teresa Martínez‑Carballo, Elena |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Álvarez‑Silvares, Esther Fernández‑Cruz, Tania Bermudez‑González, Mónica Rubio‑Cid, Paula Almeida, Agostinho Pinto, Edgar Seoane‑Pillado, Teresa Martínez‑Carballo, Elena |
dc.subject.por.fl_str_mv |
Metals Placenta Birth weight Newborn weight |
topic |
Metals Placenta Birth weight Newborn weight |
description |
Adequate gestational progression depends to a great extent on placental development, which can modify maternal and neonatal outcomes. Any environmental toxicant, including metals, with the capacity to affect the placenta can alter the development of the pregnancy and its outcome. The objective of this study was to correlate the placenta levels of 14 essential and non-essential elements with neonatal weight. We examined relationships between placental concentrations of arsenic, cadmium, cobalt, copper, mercury, lithium, manganese, molybdenum, nickel, lead, rubidium, selenium, strontium, and zinc from 79 low obstetric risk pregnant women in Ourense (Northwestern Spain, 42°20′12.1″N 7°51.844′O) with neonatal weight. We tested associations between placental metal concentrations and neonatal weight by conducting multivariable linear regressions using generalized linear models (GLM) and generalized additive models (GAM). While placental Co (p = 0.03) and Sr (p = 0.048) concentrations were associated with higher neonatal weight, concentrations of Li (p = 0.027), Mo (p = 0.049), and Se (p = 0.02) in the placenta were associated with lower newborn weight. Our findings suggest that the concentration of some metals in the placenta may affect fetal growth. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-26T15:48:38Z 2023-03-21 2023-03-21T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/23786 |
url |
http://hdl.handle.net/10400.22/23786 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Álvarez-Silvares, E., Fernández-Cruz, T., Bermudez-González, M., Rubio-Cid, P., Almeida, A., Pinto, E., Seoane-Pillado, T., & Martínez-Carballo, E. (2023). Placental levels of essential and non-essential trace element in relation to neonatal weight in Northwestern Spain: Application of generalized additive models. Environmental Science and Pollution Research, 30(22), 62566–62578. https://doi.org/10.1007/s11356-023-26560-x 0944-1344 10.1007/s11356-023-26560-x 1614-7499 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Link |
publisher.none.fl_str_mv |
Springer Link |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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