Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/158389 |
Resumo: | project LA/P/0140/202019 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. This research was funded by financial support from the Science Fund of the Republic of Serbia, IDEJE, 7730810, BioECOLogics and the Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No. 451-03-68/2022-14/200042. Publisher Copyright: © 2023 by the authors. |
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Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosinanticancer activitybiocompatibilitybiopolymer crystallinitydrug deliveryfilmPHBVpolyhydroxyalkanoateprodigiosinCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingproject LA/P/0140/202019 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. This research was funded by financial support from the Science Fund of the Republic of Serbia, IDEJE, 7730810, BioECOLogics and the Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No. 451-03-68/2022-14/200042. Publisher Copyright: © 2023 by the authors.The quest for sustainable biomaterials with excellent biocompatibility and tailorable properties has put polyhydroxyalkanoates (PHAs) into the research spotlight. However, high production costs and the lack of bioactivity limit their market penetration. To address this, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was combined with a bacterial pigment with strong anticancer activity, prodigiosin (PG), to obtain functionally enhanced PHBV-based biomaterials. The samples were produced in the form of films 115.6–118.8 µm in thickness using the solvent casting method. The effects of PG incorporation on the physical properties (morphology, biopolymer crystallinity and thermal stability) and functionality of the obtained biomaterials were investigated. PG has acted as a nucleating agent, in turn affecting the degree of crystallinity, thermal stability and morphology of the films. All samples with PG had a more organized internal structure and higher melting and degradation temperatures. The calculated degree of crystallinity of the PHBV copolymer was 53%, while the PG1, PG3 and PG3 films had values of 64.0%, 63.9% and 69.2%, respectively. Cytotoxicity studies have shown the excellent anticancer activity of films against HCT116 (colon cancer) cells, thus advancing PHBV biomedical application potential.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNPonjavic, MarijanaMalagurski, IvanaLazic, JelenaJeremic, SanjaPavlovic, VladimirPrlainovic, NevenaMaksimovic, VesnaCosovic, VladanAtanase, Leonard IonutFreitas, FilomenaMatos, MarianaNikodinovic-Runic, Jasmina2023-09-27T22:26:28Z2023-01-182023-01-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/158389eng1661-6596PURE: 72597328https://doi.org/10.3390/ijms24031906info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:45Zoai:run.unl.pt:10362/158389Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:06.847022Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| title |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| spellingShingle |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin Ponjavic, Marijana anticancer activity biocompatibility biopolymer crystallinity drug delivery film PHBV polyhydroxyalkanoate prodigiosin Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| title_full |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| title_fullStr |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| title_full_unstemmed |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| title_sort |
Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin |
| author |
Ponjavic, Marijana |
| author_facet |
Ponjavic, Marijana Malagurski, Ivana Lazic, Jelena Jeremic, Sanja Pavlovic, Vladimir Prlainovic, Nevena Maksimovic, Vesna Cosovic, Vladan Atanase, Leonard Ionut Freitas, Filomena Matos, Mariana Nikodinovic-Runic, Jasmina |
| author_role |
author |
| author2 |
Malagurski, Ivana Lazic, Jelena Jeremic, Sanja Pavlovic, Vladimir Prlainovic, Nevena Maksimovic, Vesna Cosovic, Vladan Atanase, Leonard Ionut Freitas, Filomena Matos, Mariana Nikodinovic-Runic, Jasmina |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DQ - Departamento de Química RUN |
| dc.contributor.author.fl_str_mv |
Ponjavic, Marijana Malagurski, Ivana Lazic, Jelena Jeremic, Sanja Pavlovic, Vladimir Prlainovic, Nevena Maksimovic, Vesna Cosovic, Vladan Atanase, Leonard Ionut Freitas, Filomena Matos, Mariana Nikodinovic-Runic, Jasmina |
| dc.subject.por.fl_str_mv |
anticancer activity biocompatibility biopolymer crystallinity drug delivery film PHBV polyhydroxyalkanoate prodigiosin Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| topic |
anticancer activity biocompatibility biopolymer crystallinity drug delivery film PHBV polyhydroxyalkanoate prodigiosin Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| description |
project LA/P/0140/202019 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. This research was funded by financial support from the Science Fund of the Republic of Serbia, IDEJE, 7730810, BioECOLogics and the Ministry of Education, Science and Technological Development of the Republic of Serbia, Project No. 451-03-68/2022-14/200042. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-27T22:26:28Z 2023-01-18 2023-01-18T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158389 |
| url |
http://hdl.handle.net/10362/158389 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1661-6596 PURE: 72597328 https://doi.org/10.3390/ijms24031906 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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16 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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