Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo

Detalhes bibliográficos
Autor(a) principal: Sharma,Saurabh
Data de Publicação: 2021
Outros Autores: Matharoo,Parwaaz, Bassi,Roopam
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2182-23952021000300021
Resumo: ABSTRACT Introduction: Vitiligo is an amelanotic disorder that can manifest as localized patches to near total body depigmentation. It is considered a cosmetic disease but it is accompanied by extensive psychological effects. Multiple treatments have been tried until now but no single method has achieved the desired response. Tacrolimus is frequently used for vitiligo treatment with few adverse effects. Microneedling is a newer modality of therapeutic wounding that augments drug absorption. Combination of microneedling and tacrolimus have been tried to improve the repigmentation response in vitiligo. Our objective was to assess the safety and efficacy of this combined modality. Methods: Forty patients were subjected to combination of tacrolimus 0.1% ointment and microneedling at 2 week intervals for maximum 10 sessions with a follow-up period of 6 months. Assessment was based on grading of repigmentation and clinical improvement according to vitiligo noticeability scale. Results: Excellent repigmentation was observed in 30% cases. Improvement was significantly higher in lesions present on the head and neck. Mucosal vitiligo also showed good to excellent response. No severe side effects were reported. No complications or recurrences were observed during the follow-up period. Conclusion: Combination of microneedling and tacrolimus was found to be safe and efficacious in the treatment of stable vitiligo.
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spelling Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable VitiligoDry NeedlingTacrolimusVitiligo.ABSTRACT Introduction: Vitiligo is an amelanotic disorder that can manifest as localized patches to near total body depigmentation. It is considered a cosmetic disease but it is accompanied by extensive psychological effects. Multiple treatments have been tried until now but no single method has achieved the desired response. Tacrolimus is frequently used for vitiligo treatment with few adverse effects. Microneedling is a newer modality of therapeutic wounding that augments drug absorption. Combination of microneedling and tacrolimus have been tried to improve the repigmentation response in vitiligo. Our objective was to assess the safety and efficacy of this combined modality. Methods: Forty patients were subjected to combination of tacrolimus 0.1% ointment and microneedling at 2 week intervals for maximum 10 sessions with a follow-up period of 6 months. Assessment was based on grading of repigmentation and clinical improvement according to vitiligo noticeability scale. Results: Excellent repigmentation was observed in 30% cases. Improvement was significantly higher in lesions present on the head and neck. Mucosal vitiligo also showed good to excellent response. No severe side effects were reported. No complications or recurrences were observed during the follow-up period. Conclusion: Combination of microneedling and tacrolimus was found to be safe and efficacious in the treatment of stable vitiligo.Sociedade Portuguesa de Dermatologia e Venereologia2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2182-23952021000300021Revista da Sociedade Portuguesa de Dermatologia e Venereologia v.79 n.3 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2182-23952021000300021Sharma,SaurabhMatharoo,ParwaazBassi,Roopaminfo:eu-repo/semantics/openAccess2024-02-06T17:26:32Zoai:scielo:S2182-23952021000300021Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:31:37.987044Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
spellingShingle Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
Sharma,Saurabh
Dry Needling
Tacrolimus
Vitiligo.
title_short Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_full Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_fullStr Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_full_unstemmed Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
title_sort Evaluation of Combination of Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
author Sharma,Saurabh
author_facet Sharma,Saurabh
Matharoo,Parwaaz
Bassi,Roopam
author_role author
author2 Matharoo,Parwaaz
Bassi,Roopam
author2_role author
author
dc.contributor.author.fl_str_mv Sharma,Saurabh
Matharoo,Parwaaz
Bassi,Roopam
dc.subject.por.fl_str_mv Dry Needling
Tacrolimus
Vitiligo.
topic Dry Needling
Tacrolimus
Vitiligo.
description ABSTRACT Introduction: Vitiligo is an amelanotic disorder that can manifest as localized patches to near total body depigmentation. It is considered a cosmetic disease but it is accompanied by extensive psychological effects. Multiple treatments have been tried until now but no single method has achieved the desired response. Tacrolimus is frequently used for vitiligo treatment with few adverse effects. Microneedling is a newer modality of therapeutic wounding that augments drug absorption. Combination of microneedling and tacrolimus have been tried to improve the repigmentation response in vitiligo. Our objective was to assess the safety and efficacy of this combined modality. Methods: Forty patients were subjected to combination of tacrolimus 0.1% ointment and microneedling at 2 week intervals for maximum 10 sessions with a follow-up period of 6 months. Assessment was based on grading of repigmentation and clinical improvement according to vitiligo noticeability scale. Results: Excellent repigmentation was observed in 30% cases. Improvement was significantly higher in lesions present on the head and neck. Mucosal vitiligo also showed good to excellent response. No severe side effects were reported. No complications or recurrences were observed during the follow-up period. Conclusion: Combination of microneedling and tacrolimus was found to be safe and efficacious in the treatment of stable vitiligo.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-01
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Revista da Sociedade Portuguesa de Dermatologia e Venereologia v.79 n.3 2021
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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