Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats

• Autor(a) principal: Pinello, Katia
• Data de Publicação: 2022
• Outros Autores: Amorim, Irina, Pires, Isabel, Canadas-Sousa, Ana, Catarino, José, Faísca, Pedro, Branco, Sandra, Peleteiro, Maria C., Silva, Daniela, Severo, Milton, Niza-Ribeiro, João
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10174/32696; https://doi.org/Pinello, K.; Amorim, I.;Pires, I.; Canadas-Sousa, A.; Catarino,J.; Faísca, P.; Branco, S.; Peleteiro,M.C.; Silva, D.; Severo, M.; et al. Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats. Vet. Sci. 2022, 9, 535. https://doi.org/ 10.3390/vetsci9100535; https://doi.org/ 10.3390/vetsci9100535
• topic: cancer; cat; dog; malignancy; veterinary oncology

Analysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (sex, age, and breed), topography, and geographic location using a mixed-effects logistic regression model. Cats had a higher proportion of malignant tumors (78.7%) than dogs (46.2%), and the malignancy profile was very different regarding tumors’ topographies.The mean age of malignant tumors occurred eight months later than benign ones (9.1, SD = 3.4; 9.8,SD = 3.2), in general. Species (OR = 3.96, 95%CI 3.57: 4.39) and topography (MOR = 4.10) were the two most important determinants of malignancy risk. Female dogs had a higher risk than male dogs (OR = 1.19, 95%CI 1.08: 1.31), which does not appear to be the case in cats (OR = 0.98, 95%CI0.77: 1.23). Breed contributed significantly to differences in malignancy risk in dogs (MOR = 1.56), particularly in pit bulls and boxers. District of residence was not so relevant in predicting malignancy risk (MOR = 1.14). In both species, the risk of malignancy increased by approximately 20% every three years. It could be hypothesized that species differences in genetic structure may contribute to tumor malignancy.