Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/24224 |
Resumo: | Antônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study |
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Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)Monocarboxylate transportersCD147Cancer metabolismGISTsScience & TechnologyAntônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the studyProva tipográfica (uncorrected proof)Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the immunohistochemical expression of MCT1, MCT2, MCT4 and CD147 in a series of 64 GISTs molecularly characterized for KIT, PDGFRA and BRAF mutations. MCT1, MCT2 and MCT4 were highly expressed in GISTs. CD147 expression was associated with mutated KIT (p = 0.039), as well as a progressive increase in Fletcher’s Risk of Malignancy (p = 0.020). Importantly, co-expression of MCT1 with CD147 was associated with low patient’s overall survival (p = 0.037). These findings suggest that co-expression of MCT1 with its chaperone CD147 is involved in GISTs aggressiveness, pointing to a contribution of cancer cell metabolic adaptations in GIST development and/or progression.This study was supported by CNPq – Conselho Nacional de Desenvolvimento Científico e Tecnológico (Grant number: 476936/2008-0). CP and OM received fellowships from the Portuguese Science and Technology Foundation (ref. SFRH/BPD/69479/2010 and SFRH/BD/36463/2007, respectively).Springer VerlagUniversidade do MinhoOliveira, Antônio Talvane TorresPinheiro, CélineFilho, A. L.Brito, Maria JoséMartinho, OlgaMatos, DelcioCarvalho, André LopesVazquez, Vinícius LimaSilva, Thiago BuosiScapulatempo-Neto, CristovamSaad, Sarhan SydneyReis, R. M.Baltazar, Fátima2012-022012-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24224eng0145-479X10.1007/s10863-012-9408-522281667http://link.springer.com/article/10.1007%2Fs10863-012-9408-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:02:54Zoai:repositorium.sdum.uminho.pt:1822/24224Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:52:59.137968Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| title |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| spellingShingle |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) Oliveira, Antônio Talvane Torres Monocarboxylate transporters CD147 Cancer metabolism GISTs Science & Technology |
| title_short |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| title_full |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| title_fullStr |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| title_full_unstemmed |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| title_sort |
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs) |
| author |
Oliveira, Antônio Talvane Torres |
| author_facet |
Oliveira, Antônio Talvane Torres Pinheiro, Céline Filho, A. L. Brito, Maria José Martinho, Olga Matos, Delcio Carvalho, André Lopes Vazquez, Vinícius Lima Silva, Thiago Buosi Scapulatempo-Neto, Cristovam Saad, Sarhan Sydney Reis, R. M. Baltazar, Fátima |
| author_role |
author |
| author2 |
Pinheiro, Céline Filho, A. L. Brito, Maria José Martinho, Olga Matos, Delcio Carvalho, André Lopes Vazquez, Vinícius Lima Silva, Thiago Buosi Scapulatempo-Neto, Cristovam Saad, Sarhan Sydney Reis, R. M. Baltazar, Fátima |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Oliveira, Antônio Talvane Torres Pinheiro, Céline Filho, A. L. Brito, Maria José Martinho, Olga Matos, Delcio Carvalho, André Lopes Vazquez, Vinícius Lima Silva, Thiago Buosi Scapulatempo-Neto, Cristovam Saad, Sarhan Sydney Reis, R. M. Baltazar, Fátima |
| dc.subject.por.fl_str_mv |
Monocarboxylate transporters CD147 Cancer metabolism GISTs Science & Technology |
| topic |
Monocarboxylate transporters CD147 Cancer metabolism GISTs Science & Technology |
| description |
Antônio Talvane Torres de Oliveira and Céline Pinheiro contributed equally to the study |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-02 2012-02-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/24224 |
| url |
http://hdl.handle.net/1822/24224 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0145-479X 10.1007/s10863-012-9408-5 22281667 http://link.springer.com/article/10.1007%2Fs10863-012-9408-5 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Verlag |
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Springer Verlag |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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