Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice

Detalhes bibliográficos
Autor(a) principal: Mota,Inês
Data de Publicação: 2018
Outros Autores: Gaspar,Ângela, Morais-Almeida,Mário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004
Resumo: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions, which affect a considerable percentage of the general population. These drugs can induce a wide spectrum of reactions with distinct timing, organ involvement and severity, including either immunological or nonimmunological mechanisms. A proper diagnosis can be particularly challenging since most reactions result from the pharmacological mechanism of the drug and might be dose - dependent. The clinical classification of NSAIDs - induced reactions has changed over time. Accurate diagnosis depends on strict clinical history and proper understanding of underlying mechanism. Skin testing and in vitro testing have limited usefulness. Drug challenge tests with the culprit or alternative drugs are the gold standard for the diagnosis, and provide information about drug avoidance and safe therapeutic options. In selected cases drug desensitization might be a therapeutic option. In this review, we will attempt to highlight the main aspects to be taken into account for a proper management of patients with NSAIDs hypersensitivity.
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spelling Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practiceAcetylsalicylate acidalternative drugsdesensitizationdiagnosishypersensitivitynonsteroidal anti-inflammatory drugsNonsteroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions, which affect a considerable percentage of the general population. These drugs can induce a wide spectrum of reactions with distinct timing, organ involvement and severity, including either immunological or nonimmunological mechanisms. A proper diagnosis can be particularly challenging since most reactions result from the pharmacological mechanism of the drug and might be dose - dependent. The clinical classification of NSAIDs - induced reactions has changed over time. Accurate diagnosis depends on strict clinical history and proper understanding of underlying mechanism. Skin testing and in vitro testing have limited usefulness. Drug challenge tests with the culprit or alternative drugs are the gold standard for the diagnosis, and provide information about drug avoidance and safe therapeutic options. In selected cases drug desensitization might be a therapeutic option. In this review, we will attempt to highlight the main aspects to be taken into account for a proper management of patients with NSAIDs hypersensitivity.Sociedade Portuguesa de Alergologia e Imunologia Clínica2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004Revista Portuguesa de Imunoalergologia v.26 n.3 2018reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004Mota,InêsGaspar,ÂngelaMorais-Almeida,Márioinfo:eu-repo/semantics/openAccess2024-02-06T17:04:28Zoai:scielo:S0871-97212018000300004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:40.410891Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
title Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
spellingShingle Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
Mota,Inês
Acetylsalicylate acid
alternative drugs
desensitization
diagnosis
hypersensitivity
nonsteroidal anti-inflammatory drugs
title_short Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
title_full Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
title_fullStr Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
title_full_unstemmed Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
title_sort Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
author Mota,Inês
author_facet Mota,Inês
Gaspar,Ângela
Morais-Almeida,Mário
author_role author
author2 Gaspar,Ângela
Morais-Almeida,Mário
author2_role author
author
dc.contributor.author.fl_str_mv Mota,Inês
Gaspar,Ângela
Morais-Almeida,Mário
dc.subject.por.fl_str_mv Acetylsalicylate acid
alternative drugs
desensitization
diagnosis
hypersensitivity
nonsteroidal anti-inflammatory drugs
topic Acetylsalicylate acid
alternative drugs
desensitization
diagnosis
hypersensitivity
nonsteroidal anti-inflammatory drugs
description Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions, which affect a considerable percentage of the general population. These drugs can induce a wide spectrum of reactions with distinct timing, organ involvement and severity, including either immunological or nonimmunological mechanisms. A proper diagnosis can be particularly challenging since most reactions result from the pharmacological mechanism of the drug and might be dose - dependent. The clinical classification of NSAIDs - induced reactions has changed over time. Accurate diagnosis depends on strict clinical history and proper understanding of underlying mechanism. Skin testing and in vitro testing have limited usefulness. Drug challenge tests with the culprit or alternative drugs are the gold standard for the diagnosis, and provide information about drug avoidance and safe therapeutic options. In selected cases drug desensitization might be a therapeutic option. In this review, we will attempt to highlight the main aspects to be taken into account for a proper management of patients with NSAIDs hypersensitivity.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-01
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Alergologia e Imunologia Clínica
publisher.none.fl_str_mv Sociedade Portuguesa de Alergologia e Imunologia Clínica
dc.source.none.fl_str_mv Revista Portuguesa de Imunoalergologia v.26 n.3 2018
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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