Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004 |
Resumo: | Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions, which affect a considerable percentage of the general population. These drugs can induce a wide spectrum of reactions with distinct timing, organ involvement and severity, including either immunological or nonimmunological mechanisms. A proper diagnosis can be particularly challenging since most reactions result from the pharmacological mechanism of the drug and might be dose - dependent. The clinical classification of NSAIDs - induced reactions has changed over time. Accurate diagnosis depends on strict clinical history and proper understanding of underlying mechanism. Skin testing and in vitro testing have limited usefulness. Drug challenge tests with the culprit or alternative drugs are the gold standard for the diagnosis, and provide information about drug avoidance and safe therapeutic options. In selected cases drug desensitization might be a therapeutic option. In this review, we will attempt to highlight the main aspects to be taken into account for a proper management of patients with NSAIDs hypersensitivity. |
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Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practiceAcetylsalicylate acidalternative drugsdesensitizationdiagnosishypersensitivitynonsteroidal anti-inflammatory drugsNonsteroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions, which affect a considerable percentage of the general population. These drugs can induce a wide spectrum of reactions with distinct timing, organ involvement and severity, including either immunological or nonimmunological mechanisms. A proper diagnosis can be particularly challenging since most reactions result from the pharmacological mechanism of the drug and might be dose - dependent. The clinical classification of NSAIDs - induced reactions has changed over time. Accurate diagnosis depends on strict clinical history and proper understanding of underlying mechanism. Skin testing and in vitro testing have limited usefulness. Drug challenge tests with the culprit or alternative drugs are the gold standard for the diagnosis, and provide information about drug avoidance and safe therapeutic options. In selected cases drug desensitization might be a therapeutic option. In this review, we will attempt to highlight the main aspects to be taken into account for a proper management of patients with NSAIDs hypersensitivity.Sociedade Portuguesa de Alergologia e Imunologia Clínica2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004Revista Portuguesa de Imunoalergologia v.26 n.3 2018reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004Mota,InêsGaspar,ÂngelaMorais-Almeida,Márioinfo:eu-repo/semantics/openAccess2024-02-06T17:04:28Zoai:scielo:S0871-97212018000300004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:40.410891Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
title |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
spellingShingle |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice Mota,Inês Acetylsalicylate acid alternative drugs desensitization diagnosis hypersensitivity nonsteroidal anti-inflammatory drugs |
title_short |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
title_full |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
title_fullStr |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
title_full_unstemmed |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
title_sort |
Hypersensitivity to nonsteroidal anti-inflammatory drugs: From pathogenesis to clinical practice |
author |
Mota,Inês |
author_facet |
Mota,Inês Gaspar,Ângela Morais-Almeida,Mário |
author_role |
author |
author2 |
Gaspar,Ângela Morais-Almeida,Mário |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Mota,Inês Gaspar,Ângela Morais-Almeida,Mário |
dc.subject.por.fl_str_mv |
Acetylsalicylate acid alternative drugs desensitization diagnosis hypersensitivity nonsteroidal anti-inflammatory drugs |
topic |
Acetylsalicylate acid alternative drugs desensitization diagnosis hypersensitivity nonsteroidal anti-inflammatory drugs |
description |
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions, which affect a considerable percentage of the general population. These drugs can induce a wide spectrum of reactions with distinct timing, organ involvement and severity, including either immunological or nonimmunological mechanisms. A proper diagnosis can be particularly challenging since most reactions result from the pharmacological mechanism of the drug and might be dose - dependent. The clinical classification of NSAIDs - induced reactions has changed over time. Accurate diagnosis depends on strict clinical history and proper understanding of underlying mechanism. Skin testing and in vitro testing have limited usefulness. Drug challenge tests with the culprit or alternative drugs are the gold standard for the diagnosis, and provide information about drug avoidance and safe therapeutic options. In selected cases drug desensitization might be a therapeutic option. In this review, we will attempt to highlight the main aspects to be taken into account for a proper management of patients with NSAIDs hypersensitivity. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0871-97212018000300004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Alergologia e Imunologia Clínica |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Alergologia e Imunologia Clínica |
dc.source.none.fl_str_mv |
Revista Portuguesa de Imunoalergologia v.26 n.3 2018 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137277610295296 |