Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy

Detalhes bibliográficos
Autor(a) principal: Osório, Luís
Data de Publicação: 2011
Outros Autores: Silva, David, Autorino, Riccardo, Damiano, Rocco, Correia-Pinto, Jorge, Lima, Estêvão Augusto Rodrigues de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/67459
Resumo: OBJECTIVE To assess the feasibility of pure natural orifice transluminal endoscopic surgery (NOTES) transvesical venous ligation mimicking bilateral varicocelectomy in an animal model.MATERIALS AND METHODS Transvesical NOTES bilateral venous ligation was performed in 6 female pigs by considering lower epigastric vessels as a model for gonadal vessels. Under flexible cystoscopic guidance, a cystotomy was created on the anterior bladder. The flexible cystoscope was introduced through the over tube, and the lower epigastric vessels were visualized in retroflexion. Thulium laser was used to cut and coagulate the vessels. A bladder catheter was left in place for 4 days in all animals and they were sacrificed 15 days after the procedure.RESULTS The procedure was successfully carried out in all animals without intraoperative complications. Epigastric vessels were safely cut and coagulated using the thulium laser. Median time for the overall procedure, including establishment of the transvesical port, was 23 minutes (range 20-30). No complications were encountered during the postoperative follow-up period. Postmortem examination revealed complete coagulation and separation of vessels.CONCLUSION An animal model mimicking a NOTES transvesical bilateral varicocelectomy procedure is successfully shown in the present study. Despite being encouraging, these novel findings need to be interpreted with caution. Further research is warranted and development of purpose-built instrumentation is awaited to define potential urological applications of transvesical NOTES.
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spelling Pure NOTES transvesical venous ligation: translational animal model of varicocelectomyAnimalsDisease Models, AnimalFeasibility StudiesFemaleLigationMaleSwineUrologic Surgical Procedures, MaleVaricoceleVeinsNatural Orifice Endoscopic SurgeryScience & TechnologyOBJECTIVE To assess the feasibility of pure natural orifice transluminal endoscopic surgery (NOTES) transvesical venous ligation mimicking bilateral varicocelectomy in an animal model.MATERIALS AND METHODS Transvesical NOTES bilateral venous ligation was performed in 6 female pigs by considering lower epigastric vessels as a model for gonadal vessels. Under flexible cystoscopic guidance, a cystotomy was created on the anterior bladder. The flexible cystoscope was introduced through the over tube, and the lower epigastric vessels were visualized in retroflexion. Thulium laser was used to cut and coagulate the vessels. A bladder catheter was left in place for 4 days in all animals and they were sacrificed 15 days after the procedure.RESULTS The procedure was successfully carried out in all animals without intraoperative complications. Epigastric vessels were safely cut and coagulated using the thulium laser. Median time for the overall procedure, including establishment of the transvesical port, was 23 minutes (range 20-30). No complications were encountered during the postoperative follow-up period. Postmortem examination revealed complete coagulation and separation of vessels.CONCLUSION An animal model mimicking a NOTES transvesical bilateral varicocelectomy procedure is successfully shown in the present study. Despite being encouraging, these novel findings need to be interpreted with caution. Further research is warranted and development of purpose-built instrumentation is awaited to define potential urological applications of transvesical NOTES.Support for this study was provided by Grants PTDC/SAU-OSM/105578/2008 from FCT-Portugal and Karl Storz (Tuttlingen, Germany).From the Surgical Sciences Research Domain, Life and Health Sciences ResearchInstitute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; Department of Medicine, Centro Hospitalar do Médio Ave, Famalicão, Portugal;Urology Clinic, Second University of Naples, Italy; Urology Unit, Magna GraeciaUniversity, Catanzaro, Italy; Department of Pediatric Surgery, Hospital São João,Porto, Portugal; and Dept of Urology, Hospital de Braga, Braga, PortugaElsevier Science IncUniversidade do MinhoOsório, LuísSilva, DavidAutorino, RiccardoDamiano, RoccoCorreia-Pinto, JorgeLima, Estêvão Augusto Rodrigues de2011-112011-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67459eng0090-429510.1016/j.urology.2011.05.06721890181https://www.sciencedirect.com/science/article/pii/S0090429511020966info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:20:37Zoai:repositorium.sdum.uminho.pt:1822/67459Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:13:48.033309Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
title Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
spellingShingle Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
Osório, Luís
Animals
Disease Models, Animal
Feasibility Studies
Female
Ligation
Male
Swine
Urologic Surgical Procedures, Male
Varicocele
Veins
Natural Orifice Endoscopic Surgery
Science & Technology
title_short Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
title_full Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
title_fullStr Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
title_full_unstemmed Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
title_sort Pure NOTES transvesical venous ligation: translational animal model of varicocelectomy
author Osório, Luís
author_facet Osório, Luís
Silva, David
Autorino, Riccardo
Damiano, Rocco
Correia-Pinto, Jorge
Lima, Estêvão Augusto Rodrigues de
author_role author
author2 Silva, David
Autorino, Riccardo
Damiano, Rocco
Correia-Pinto, Jorge
Lima, Estêvão Augusto Rodrigues de
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Osório, Luís
Silva, David
Autorino, Riccardo
Damiano, Rocco
Correia-Pinto, Jorge
Lima, Estêvão Augusto Rodrigues de
dc.subject.por.fl_str_mv Animals
Disease Models, Animal
Feasibility Studies
Female
Ligation
Male
Swine
Urologic Surgical Procedures, Male
Varicocele
Veins
Natural Orifice Endoscopic Surgery
Science & Technology
topic Animals
Disease Models, Animal
Feasibility Studies
Female
Ligation
Male
Swine
Urologic Surgical Procedures, Male
Varicocele
Veins
Natural Orifice Endoscopic Surgery
Science & Technology
description OBJECTIVE To assess the feasibility of pure natural orifice transluminal endoscopic surgery (NOTES) transvesical venous ligation mimicking bilateral varicocelectomy in an animal model.MATERIALS AND METHODS Transvesical NOTES bilateral venous ligation was performed in 6 female pigs by considering lower epigastric vessels as a model for gonadal vessels. Under flexible cystoscopic guidance, a cystotomy was created on the anterior bladder. The flexible cystoscope was introduced through the over tube, and the lower epigastric vessels were visualized in retroflexion. Thulium laser was used to cut and coagulate the vessels. A bladder catheter was left in place for 4 days in all animals and they were sacrificed 15 days after the procedure.RESULTS The procedure was successfully carried out in all animals without intraoperative complications. Epigastric vessels were safely cut and coagulated using the thulium laser. Median time for the overall procedure, including establishment of the transvesical port, was 23 minutes (range 20-30). No complications were encountered during the postoperative follow-up period. Postmortem examination revealed complete coagulation and separation of vessels.CONCLUSION An animal model mimicking a NOTES transvesical bilateral varicocelectomy procedure is successfully shown in the present study. Despite being encouraging, these novel findings need to be interpreted with caution. Further research is warranted and development of purpose-built instrumentation is awaited to define potential urological applications of transvesical NOTES.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
2011-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/67459
url http://hdl.handle.net/1822/67459
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0090-4295
10.1016/j.urology.2011.05.067
21890181
https://www.sciencedirect.com/science/article/pii/S0090429511020966
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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