Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/4676 https://doi.org/10.1016/j.brainresrev.2008.03.002 |
Resumo: | Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions. Neurological impairments observed in drug addicts may reflect drug-induced neuronal dysfunction and neurotoxicity. The drugs of abuse directly or indirectly affect neurotransmitter systems, particularly dopaminergic and glutamatergic neurons. This review explores the literature reporting cellular and molecular alterations reflecting the cytotoxicity induced by amphetamines, cocaine and opiates in neuronal systems. The neurotoxic effects of drugs of abuse are often associated with oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis, among other mechanisms. Understanding the mechanisms that underlie brain dysfunction observed in drug-addicted individuals may contribute to improve the treatment of drug addiction, which may have social and economic consequences. |
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Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugsDrug of abuseNeurotoxicityApoptosisOxidative stressGlutamateDopamineCocaineAmphetamineSubstance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions. Neurological impairments observed in drug addicts may reflect drug-induced neuronal dysfunction and neurotoxicity. The drugs of abuse directly or indirectly affect neurotransmitter systems, particularly dopaminergic and glutamatergic neurons. This review explores the literature reporting cellular and molecular alterations reflecting the cytotoxicity induced by amphetamines, cocaine and opiates in neuronal systems. The neurotoxic effects of drugs of abuse are often associated with oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis, among other mechanisms. Understanding the mechanisms that underlie brain dysfunction observed in drug-addicted individuals may contribute to improve the treatment of drug addiction, which may have social and economic consequences.http://www.sciencedirect.com/science/article/B6SYS-4S50K2J-1/1/7d11c902193bfa3f1f57030572f7034e2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4676http://hdl.handle.net/10316/4676https://doi.org/10.1016/j.brainresrev.2008.03.002engBrain Research Reviews. 58:1 (2008) 192-208Cunha-Oliveira, TeresaRego, Ana CristinaOliveira, Catarina R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:48:50Zoai:estudogeral.uc.pt:10316/4676Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:26.266323Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
title |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
spellingShingle |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs Cunha-Oliveira, Teresa Drug of abuse Neurotoxicity Apoptosis Oxidative stress Glutamate Dopamine Cocaine Amphetamine |
title_short |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
title_full |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
title_fullStr |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
title_full_unstemmed |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
title_sort |
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs |
author |
Cunha-Oliveira, Teresa |
author_facet |
Cunha-Oliveira, Teresa Rego, Ana Cristina Oliveira, Catarina R. |
author_role |
author |
author2 |
Rego, Ana Cristina Oliveira, Catarina R. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Cunha-Oliveira, Teresa Rego, Ana Cristina Oliveira, Catarina R. |
dc.subject.por.fl_str_mv |
Drug of abuse Neurotoxicity Apoptosis Oxidative stress Glutamate Dopamine Cocaine Amphetamine |
topic |
Drug of abuse Neurotoxicity Apoptosis Oxidative stress Glutamate Dopamine Cocaine Amphetamine |
description |
Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions. Neurological impairments observed in drug addicts may reflect drug-induced neuronal dysfunction and neurotoxicity. The drugs of abuse directly or indirectly affect neurotransmitter systems, particularly dopaminergic and glutamatergic neurons. This review explores the literature reporting cellular and molecular alterations reflecting the cytotoxicity induced by amphetamines, cocaine and opiates in neuronal systems. The neurotoxic effects of drugs of abuse are often associated with oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis, among other mechanisms. Understanding the mechanisms that underlie brain dysfunction observed in drug-addicted individuals may contribute to improve the treatment of drug addiction, which may have social and economic consequences. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/4676 http://hdl.handle.net/10316/4676 https://doi.org/10.1016/j.brainresrev.2008.03.002 |
url |
http://hdl.handle.net/10316/4676 https://doi.org/10.1016/j.brainresrev.2008.03.002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brain Research Reviews. 58:1 (2008) 192-208 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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