Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin

Detalhes bibliográficos
Autor(a) principal: Cruz, Andre
Data de Publicação: 2016
Outros Autores: Bretes, Luis, Reis, Carlos, Furtado, Irene
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/9526
Resumo: Inferior vena cava leiomyosarcoma is a very rare tumor, accounting for only 0.5% of all soft tissue sarcomas. As the other leyomiosarcomas of vascular origin, they have a poor prognosis, and radical resection with surgical margins free of tumor is the only potentially curative treatment. We present a case of a 46 year-old woman with metastatic inferior vena cava leiomyosarcoma who progressed after anthracyclines and ifosfamide and achieved a complete and sustained response with trabectedin. Beyond progression, the patient started third line treatment with pazopanib. A brief review of literature is also given. This case supports the efectiveness of a recent therapeutic agent, with an impressive progression-free survival in a recurrent metastatic inferior vena cava leiomyosarcoma.
id RCAP_27153c9116631c6b6b9116f648f83596
oai_identifier_str oai:sapientia.ualg.pt:10400.1/9526
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with TrabectedinInferior vena cava leiomyosarcoma is a very rare tumor, accounting for only 0.5% of all soft tissue sarcomas. As the other leyomiosarcomas of vascular origin, they have a poor prognosis, and radical resection with surgical margins free of tumor is the only potentially curative treatment. We present a case of a 46 year-old woman with metastatic inferior vena cava leiomyosarcoma who progressed after anthracyclines and ifosfamide and achieved a complete and sustained response with trabectedin. Beyond progression, the patient started third line treatment with pazopanib. A brief review of literature is also given. This case supports the efectiveness of a recent therapeutic agent, with an impressive progression-free survival in a recurrent metastatic inferior vena cava leiomyosarcoma.SapientiaCruz, AndreBretes, LuisReis, CarlosFurtado, Irene2017-04-07T15:56:47Z2016-042016-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/9526eng1646-075810.20344/amp.7211info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:21:00Zoai:sapientia.ualg.pt:10400.1/9526Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:01:27.034492Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
title Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
spellingShingle Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
Cruz, Andre
title_short Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
title_full Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
title_fullStr Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
title_full_unstemmed Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
title_sort Leiomyosarcoma of the Inferior Vena Cava: a case report of complete and sustained response with Trabectedin
author Cruz, Andre
author_facet Cruz, Andre
Bretes, Luis
Reis, Carlos
Furtado, Irene
author_role author
author2 Bretes, Luis
Reis, Carlos
Furtado, Irene
author2_role author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Cruz, Andre
Bretes, Luis
Reis, Carlos
Furtado, Irene
description Inferior vena cava leiomyosarcoma is a very rare tumor, accounting for only 0.5% of all soft tissue sarcomas. As the other leyomiosarcomas of vascular origin, they have a poor prognosis, and radical resection with surgical margins free of tumor is the only potentially curative treatment. We present a case of a 46 year-old woman with metastatic inferior vena cava leiomyosarcoma who progressed after anthracyclines and ifosfamide and achieved a complete and sustained response with trabectedin. Beyond progression, the patient started third line treatment with pazopanib. A brief review of literature is also given. This case supports the efectiveness of a recent therapeutic agent, with an impressive progression-free survival in a recurrent metastatic inferior vena cava leiomyosarcoma.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
2016-04-01T00:00:00Z
2017-04-07T15:56:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/9526
url http://hdl.handle.net/10400.1/9526
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1646-0758
10.20344/amp.7211
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133243918778368

Registros relacionados