Coronavirus Disease 2019: Clinical Review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957 |
Resumo: | Introduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China’s Hubei Province and has been declared a public health emergency of international concern by the World Health Organization since January 2020.Material and Methods: A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019.Discussion: This new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2, enters human cells that express angiotensin-converting enzyme II receptors, which exist in the respiratory, gastrointestinal and genitourinary tracts and heart, causing coronavirus disease. Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing.Conclusion: Despite intensive research, the exact origin of the virus and pathophysiology of coronavirus disease is not yet completely known, and clinically approved vaccines and drugs that target severe acute respiratory syndrome coronavirus 2 are lacking. |
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Coronavirus Disease 2019: Clinical ReviewDoença de Coronavírus 2019: Revisão ClínicaCoronavirus InfectionsCOVID-19Severe Acute Respiratory SyndromeCOVID-19Infecções por CoronavírusSíndrome Respiratória Aguda GraveIntroduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China’s Hubei Province and has been declared a public health emergency of international concern by the World Health Organization since January 2020.Material and Methods: A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019.Discussion: This new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2, enters human cells that express angiotensin-converting enzyme II receptors, which exist in the respiratory, gastrointestinal and genitourinary tracts and heart, causing coronavirus disease. Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing.Conclusion: Despite intensive research, the exact origin of the virus and pathophysiology of coronavirus disease is not yet completely known, and clinically approved vaccines and drugs that target severe acute respiratory syndrome coronavirus 2 are lacking.Introdução: Em dezembro de 2019, ocorreu um surto de pneumonia causada por uma nova estirpe de coronavírus em Wuhan, a capital da província de Hubei, na China central e foi declarado emergência de saúde pública de âmbito internacional pela Organização Mundial de Saúde, em janeiro de 2020.Material e Métodos: Foi realizada uma pesquisa na base de dados PubMed, de forma a sintetizar a informação mais recentemente publicada sobre a epidemiologia, definição, fisiopatologia, manifestações clínicas, tratamento, prognóstico e prevenção da doença de coronavírus 2019.Discussão: Esta nova estirpe de coronavírus, denominada coronavírus da síndrome respiratória aguda grave 2 infeta células que expressem o recetor da enzima conversora da angiotensina tipo II, existentes nos tratos respiratório, gastrointestinal e geniturinário e no coração, provocando a doença de coronavírus 2019. A transmissão ocorre essencialmente através do trato respiratório e os principais sintomas são febre, tosse e dispneia. O diagnóstico é baseado em critérios epidemiológicos, clínicos e imagiológicos, sendo a confirmação da doença realizada através da análise de ácidos nucleicos.Conclusão: Apesar da extensa investigação, ainda não é totalmente conhecida a origem do vírus, a fisiopatologia da doença e não existem vacinas nem tratamento direcionados a esta nova estirpe de coronavírus.Ordem dos Médicos2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957oai:ojs.www.actamedicaportuguesa.com:article/13957Acta Médica Portuguesa; Vol. 33 No. 7-8 (2020): July-August; 505-511Acta Médica Portuguesa; Vol. 33 N.º 7-8 (2020): Julho-Agosto; 505-5111646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/5990https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/12536https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/12537https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/12608Direitos de Autor (c) 2020 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessGouveia, Cristina CarvalhoCampos, Luís2022-12-20T11:07:04Zoai:ojs.www.actamedicaportuguesa.com:article/13957Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:25.117287Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Coronavirus Disease 2019: Clinical Review Doença de Coronavírus 2019: Revisão Clínica |
title |
Coronavirus Disease 2019: Clinical Review |
spellingShingle |
Coronavirus Disease 2019: Clinical Review Gouveia, Cristina Carvalho Coronavirus Infections COVID-19 Severe Acute Respiratory Syndrome COVID-19 Infecções por Coronavírus Síndrome Respiratória Aguda Grave |
title_short |
Coronavirus Disease 2019: Clinical Review |
title_full |
Coronavirus Disease 2019: Clinical Review |
title_fullStr |
Coronavirus Disease 2019: Clinical Review |
title_full_unstemmed |
Coronavirus Disease 2019: Clinical Review |
title_sort |
Coronavirus Disease 2019: Clinical Review |
author |
Gouveia, Cristina Carvalho |
author_facet |
Gouveia, Cristina Carvalho Campos, Luís |
author_role |
author |
author2 |
Campos, Luís |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Gouveia, Cristina Carvalho Campos, Luís |
dc.subject.por.fl_str_mv |
Coronavirus Infections COVID-19 Severe Acute Respiratory Syndrome COVID-19 Infecções por Coronavírus Síndrome Respiratória Aguda Grave |
topic |
Coronavirus Infections COVID-19 Severe Acute Respiratory Syndrome COVID-19 Infecções por Coronavírus Síndrome Respiratória Aguda Grave |
description |
Introduction: In December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in Wuhan, the capital of Central China’s Hubei Province and has been declared a public health emergency of international concern by the World Health Organization since January 2020.Material and Methods: A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019.Discussion: This new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2, enters human cells that express angiotensin-converting enzyme II receptors, which exist in the respiratory, gastrointestinal and genitourinary tracts and heart, causing coronavirus disease. Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing.Conclusion: Despite intensive research, the exact origin of the virus and pathophysiology of coronavirus disease is not yet completely known, and clinically approved vaccines and drugs that target severe acute respiratory syndrome coronavirus 2 are lacking. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957 oai:ojs.www.actamedicaportuguesa.com:article/13957 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/13957 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/5990 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/12536 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/12537 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/13957/12608 |
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Direitos de Autor (c) 2020 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2020 Acta Médica Portuguesa |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 33 No. 7-8 (2020): July-August; 505-511 Acta Médica Portuguesa; Vol. 33 N.º 7-8 (2020): Julho-Agosto; 505-511 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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