Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1080/17402520600554930 |
Resumo: | To explore whether antibodies against β2-glycoprotein I (β2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndrome (PAPS). As many as 29 thrombotic patients with PAPS, 10 subjects with idiopathic antiphospholipid antibodies (aPL) without thrombosis, 17 thrombotic patients with inherited thrombophilia and 23 healthy controls were investigated. The following were measured in all participants: β2GPI-oxLDL complexes, IgG anti-β2GPI-oxLig-1, IgG anti-β2GPI-oxLDL antibodies (ELISA), PONa, (para-nitrophenol method), IMT of common carotid (CC) artery, carotid bifurcation (B), internal carotid (IC) by high resolution sonography. β2GPI-oxLDL complex was highest in the control group (p < 0.01), whereas, IgG anti-β2GPI-oxLig1 and IgG anti-β2GPI-oxLDL were highest in PAPS (p < 0.0001). In healthy controls, β2GPI- oxLDL complexes positively correlated to IMT of the IC (p = 0.007) and negatively to PONa after correction for age (p < 0.03). PONa inversely correlated with age (p = 0.008). In PAPS, IgG anti-β2GPI-oxLig-1 independently predicted PONa (p = 0.02) and IMT of B (p = 0.003), CC, (p = 0.03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMTof B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). IgG anti- β2GPI-oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity. |
id |
RCAP_27b23c93648f4bad97e7c9444fdf7e97 |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/23451 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndromeCarotid arteriesOxidationPrimary antiphospholipid syndromeImmunologyCell BiologyDevelopmental BiologyTo explore whether antibodies against β2-glycoprotein I (β2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndrome (PAPS). As many as 29 thrombotic patients with PAPS, 10 subjects with idiopathic antiphospholipid antibodies (aPL) without thrombosis, 17 thrombotic patients with inherited thrombophilia and 23 healthy controls were investigated. The following were measured in all participants: β2GPI-oxLDL complexes, IgG anti-β2GPI-oxLig-1, IgG anti-β2GPI-oxLDL antibodies (ELISA), PONa, (para-nitrophenol method), IMT of common carotid (CC) artery, carotid bifurcation (B), internal carotid (IC) by high resolution sonography. β2GPI-oxLDL complex was highest in the control group (p < 0.01), whereas, IgG anti-β2GPI-oxLig1 and IgG anti-β2GPI-oxLDL were highest in PAPS (p < 0.0001). In healthy controls, β2GPI- oxLDL complexes positively correlated to IMT of the IC (p = 0.007) and negatively to PONa after correction for age (p < 0.03). PONa inversely correlated with age (p = 0.008). In PAPS, IgG anti-β2GPI-oxLig-1 independently predicted PONa (p = 0.02) and IMT of B (p = 0.003), CC, (p = 0.03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMTof B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). IgG anti- β2GPI-oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAmes, P R JDelgado Alves, JLopez, L. R.Gentile, F.Margarita, A.Pizzella, L.Batuca, JScenna, G.Brancaccio, V.Matsuura, E.2017-09-19T22:03:38Z2006-03-012006-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttps://doi.org/10.1080/17402520600554930eng1740-2522PURE: 3141385http://www.scopus.com/inward/record.url?scp=33645845734&partnerID=8YFLogxKhttps://doi.org/10.1080/17402520600554930info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:11:43Zoai:run.unl.pt:10362/23451Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:48.135709Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
title |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
spellingShingle |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome Ames, P R J Carotid arteries Oxidation Primary antiphospholipid syndrome Immunology Cell Biology Developmental Biology |
title_short |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
title_full |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
title_fullStr |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
title_full_unstemmed |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
title_sort |
Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome |
author |
Ames, P R J |
author_facet |
Ames, P R J Delgado Alves, J Lopez, L. R. Gentile, F. Margarita, A. Pizzella, L. Batuca, J Scenna, G. Brancaccio, V. Matsuura, E. |
author_role |
author |
author2 |
Delgado Alves, J Lopez, L. R. Gentile, F. Margarita, A. Pizzella, L. Batuca, J Scenna, G. Brancaccio, V. Matsuura, E. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Ames, P R J Delgado Alves, J Lopez, L. R. Gentile, F. Margarita, A. Pizzella, L. Batuca, J Scenna, G. Brancaccio, V. Matsuura, E. |
dc.subject.por.fl_str_mv |
Carotid arteries Oxidation Primary antiphospholipid syndrome Immunology Cell Biology Developmental Biology |
topic |
Carotid arteries Oxidation Primary antiphospholipid syndrome Immunology Cell Biology Developmental Biology |
description |
To explore whether antibodies against β2-glycoprotein I (β2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndrome (PAPS). As many as 29 thrombotic patients with PAPS, 10 subjects with idiopathic antiphospholipid antibodies (aPL) without thrombosis, 17 thrombotic patients with inherited thrombophilia and 23 healthy controls were investigated. The following were measured in all participants: β2GPI-oxLDL complexes, IgG anti-β2GPI-oxLig-1, IgG anti-β2GPI-oxLDL antibodies (ELISA), PONa, (para-nitrophenol method), IMT of common carotid (CC) artery, carotid bifurcation (B), internal carotid (IC) by high resolution sonography. β2GPI-oxLDL complex was highest in the control group (p < 0.01), whereas, IgG anti-β2GPI-oxLig1 and IgG anti-β2GPI-oxLDL were highest in PAPS (p < 0.0001). In healthy controls, β2GPI- oxLDL complexes positively correlated to IMT of the IC (p = 0.007) and negatively to PONa after correction for age (p < 0.03). PONa inversely correlated with age (p = 0.008). In PAPS, IgG anti-β2GPI-oxLig-1 independently predicted PONa (p = 0.02) and IMT of B (p = 0.003), CC, (p = 0.03) and of IC (p = 0.04). In PAPS, PONa inversely correlated to the IMTof B, CC and IC (p = 0.01, 0.02 and 0.003, respectively). IgG anti- β2GPI-oxLig-1 may be involved in PAPS related atherogenesis via decreased PON activity. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-03-01 2006-03-01T00:00:00Z 2017-09-19T22:03:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1080/17402520600554930 |
url |
https://doi.org/10.1080/17402520600554930 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1740-2522 PURE: 3141385 http://www.scopus.com/inward/record.url?scp=33645845734&partnerID=8YFLogxK https://doi.org/10.1080/17402520600554930 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137905039376384 |