Swine enteric colibacillosis: Current treatment avenues and future directions
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/82632 |
Resumo: | The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full#supplementary-material |
id |
RCAP_27fe4501e837b4f72a15169d50b58c19 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/82632 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Swine enteric colibacillosis: Current treatment avenues and future directionsenteric colibacillosispost-weaning diarrheagutmicrobiomeantibiotic therapyzinc oxidenovel antimicrobial approachesThe Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full#supplementary-materialEnteric colibacillosis is a common disease in nursing and weanling pigs. It is caused by the colonization of the small intestine by enterotoxigenic strains of Escherichia coli (ETEC) that make use of specific fimbria or pili to adhere to the absorptive epithelial cells of the jejunum and ileum. Once attached, and when both the immunological systems and the gut microbiota are poorly developed, ETEC produce one or more enterotoxins that can have local and, further on, systemic effects. These enterotoxins cause fluid and electrolytes to be secreted into the intestinal lumen of animals, which results in diarrhea, dehydration, and acidosis. From the diversity of control strategies, antibiotics and zinc oxide are the ones that have contributed more significantly to mitigating post-weaning diarrhea (PWD) economic losses. However, concerns about antibiotic resistance determined the restriction on the use of critically important antimicrobials in food-producing animals and the prohibition of their use as growth promoters. As such, it is important now to begin the transition from these preventive/control measures to other, more sustainable, approaches. This review provides a quick synopsis of the currently approved and available therapies for PWD treatment while presenting an overview of novel antimicrobial strategies that are being explored for the control and treatment of this infection, including, prebiotics, probiotics, synbiotics, organic acids, bacteriophages, spray-dried plasma, antibodies, phytogenic substances, antisense oligonucleotides, and aptamers.Research in swine colibacillosis in CA Laboratory was supported by funding from the Fundação para a Ciência e a Tecnologia (FCT) Strategic Project Unit PTDC/CVT-CVT/4620/2021. It was also partially funded by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC), by FCT under the scope of the strategic funding of UIDB/04469/2020 unit (CEB), and by LABBELS-Associate Laboratory in Biotechnology, Bioengineering, and Microelectromechnaical Systems, LA/P/0029/2020.info:eu-repo/semantics/publishedVersionFrontiers Media S.A.Universidade do MinhoCastro, JoanaBarros, Maria MargaridaAraújo, DanielaCampos, Ana MariaOliveira, RicardoSilva, Sónia CarinaAlmeida, Carina2022-10-282022-10-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/82632engCastro, J., Barros, M. M., Araújo, D., Campos, A. M., Oliveira, R., Silva, S., & Almeida, C. (2022, October 28). Swine enteric colibacillosis: Current treatment avenues and future directions. Frontiers in Veterinary Science. Frontiers Media SA. http://doi.org/10.3389/fvets.2022.9812072297-176910.3389/fvets.2022.981207981207https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-30T01:24:17Zoai:repositorium.sdum.uminho.pt:1822/82632Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:24.176897Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Swine enteric colibacillosis: Current treatment avenues and future directions |
title |
Swine enteric colibacillosis: Current treatment avenues and future directions |
spellingShingle |
Swine enteric colibacillosis: Current treatment avenues and future directions Castro, Joana enteric colibacillosis post-weaning diarrhea gutmicrobiome antibiotic therapy zinc oxide novel antimicrobial approaches |
title_short |
Swine enteric colibacillosis: Current treatment avenues and future directions |
title_full |
Swine enteric colibacillosis: Current treatment avenues and future directions |
title_fullStr |
Swine enteric colibacillosis: Current treatment avenues and future directions |
title_full_unstemmed |
Swine enteric colibacillosis: Current treatment avenues and future directions |
title_sort |
Swine enteric colibacillosis: Current treatment avenues and future directions |
author |
Castro, Joana |
author_facet |
Castro, Joana Barros, Maria Margarida Araújo, Daniela Campos, Ana Maria Oliveira, Ricardo Silva, Sónia Carina Almeida, Carina |
author_role |
author |
author2 |
Barros, Maria Margarida Araújo, Daniela Campos, Ana Maria Oliveira, Ricardo Silva, Sónia Carina Almeida, Carina |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Castro, Joana Barros, Maria Margarida Araújo, Daniela Campos, Ana Maria Oliveira, Ricardo Silva, Sónia Carina Almeida, Carina |
dc.subject.por.fl_str_mv |
enteric colibacillosis post-weaning diarrhea gutmicrobiome antibiotic therapy zinc oxide novel antimicrobial approaches |
topic |
enteric colibacillosis post-weaning diarrhea gutmicrobiome antibiotic therapy zinc oxide novel antimicrobial approaches |
description |
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full#supplementary-material |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-28 2022-10-28T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/82632 |
url |
https://hdl.handle.net/1822/82632 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Castro, J., Barros, M. M., Araújo, D., Campos, A. M., Oliveira, R., Silva, S., & Almeida, C. (2022, October 28). Swine enteric colibacillosis: Current treatment avenues and future directions. Frontiers in Veterinary Science. Frontiers Media SA. http://doi.org/10.3389/fvets.2022.981207 2297-1769 10.3389/fvets.2022.981207 981207 https://www.frontiersin.org/articles/10.3389/fvets.2022.981207/full |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132453602852864 |