Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk

Detalhes bibliográficos
Autor(a) principal: Velho, Tiago R.
Data de Publicação: 2022
Outros Autores: Ferreira, Ricardo, Willmann, Katharina, Pedroso, Dora, Paixão, Tiago, Pereira, Rafael Maniés, Junqueira, Nádia, Guerra, Nuno, Brito, Dulce, Almeida, Ana G., Nobre, Angelo, Köcher, Thomas, Pinto, Fausto J., Moita, Luís Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54865
Resumo: Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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spelling Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding riskCardiac surgeryInflammationMetabolismPlateletPostoperative bleeding.Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.Cardiac surgery is frequently associated with significant postoperative bleeding. Platelet-dysfunction is the main cardiopulmonary bypass (CPB)-induced hemostatic defect. Not only the number of platelets decreases, but also the remaining are functionally impaired. Although lipid metabolism is crucial for platelet function, little is known regarding platelet metabolic changes associated with CPB-dysfunction. Our aim is to explore possible contribution of metabolic perturbations for platelet dysfunction after cardiac surgery. Design: Prospective cohort study. Setting: Tertiary academic cardiothoracic-surgery ICU. Patients: Thirty-three patients submitted to elective surgical aortic valve replacement. Interventions: Samples from patients were collected at three time points (preoperative, 6- and 24-hr postoperative). Untargeted metabolic analysis using high-performance liquid chromatography-tandem mass spectrometry was performed to compare patients with significant postoperative bleeding with patients without hemorrhage. Principal component analyses, Wilcoxon matched-pairs signed-rank tests, adjusted to FDR, and pairwise comparison were used to identify pathways of interest. Enrichment and pathway metabolomic complemented the analyses. Measurements and main results: We identified a platelet-related signature based on an overrepresentation of changes in known fatty acid metabolism pathways involved in platelet function. We observed that arachidonic acid (AA) levels and other metabolites from the pathway were reduced at 6 and 24 hours, independently from antiagreggation therapy and platelet count. Concentrations of preoperative AA were inversely correlated with postoperative chest tube blood loss but were not correlated with platelet count in the preoperative, at 6 or at 24 hours. Patients with significant postoperative blood-loss had considerably lower values of AA and higher transfusion rates. Values of postoperative interleukin-6 were strongly correlated with AA variability. Conclusions and relevance: Our observations suggest that an inflammatory-related perturbation of AA metabolism is a signature of cardiac surgery with CPB and that preoperative levels of AA may be more relevant than platelet count to anticipate and prevent postoperative blood loss in patients submitted to cardiac surgery with CPB.Wolters KluwerRepositório da Universidade de LisboaVelho, Tiago R.Ferreira, RicardoWillmann, KatharinaPedroso, DoraPaixão, TiagoPereira, Rafael ManiésJunqueira, NádiaGuerra, NunoBrito, DulceAlmeida, Ana G.Nobre, AngeloKöcher, ThomasPinto, Fausto J.Moita, Luís Ferreira2022-10-25T10:57:46Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54865engCrit Care Explor. 2022 Oct 10;4(10):e076310.1097/CCE.00000000000007632639-8028info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:33Zoai:repositorio.ul.pt:10451/54865Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:38.196119Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
title Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
spellingShingle Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
Velho, Tiago R.
Cardiac surgery
Inflammation
Metabolism
Platelet
Postoperative bleeding.
title_short Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
title_full Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
title_fullStr Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
title_full_unstemmed Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
title_sort Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding risk
author Velho, Tiago R.
author_facet Velho, Tiago R.
Ferreira, Ricardo
Willmann, Katharina
Pedroso, Dora
Paixão, Tiago
Pereira, Rafael Maniés
Junqueira, Nádia
Guerra, Nuno
Brito, Dulce
Almeida, Ana G.
Nobre, Angelo
Köcher, Thomas
Pinto, Fausto J.
Moita, Luís Ferreira
author_role author
author2 Ferreira, Ricardo
Willmann, Katharina
Pedroso, Dora
Paixão, Tiago
Pereira, Rafael Maniés
Junqueira, Nádia
Guerra, Nuno
Brito, Dulce
Almeida, Ana G.
Nobre, Angelo
Köcher, Thomas
Pinto, Fausto J.
Moita, Luís Ferreira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Velho, Tiago R.
Ferreira, Ricardo
Willmann, Katharina
Pedroso, Dora
Paixão, Tiago
Pereira, Rafael Maniés
Junqueira, Nádia
Guerra, Nuno
Brito, Dulce
Almeida, Ana G.
Nobre, Angelo
Köcher, Thomas
Pinto, Fausto J.
Moita, Luís Ferreira
dc.subject.por.fl_str_mv Cardiac surgery
Inflammation
Metabolism
Platelet
Postoperative bleeding.
topic Cardiac surgery
Inflammation
Metabolism
Platelet
Postoperative bleeding.
description Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-25T10:57:46Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54865
url http://hdl.handle.net/10451/54865
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Crit Care Explor. 2022 Oct 10;4(10):e0763
10.1097/CCE.0000000000000763
2639-8028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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