Dependence of Viscosity and Diffusion on β-Cyclodextrin and Chloroquine Diphosphate Interactions

• Autor(a) principal: Musilová, Lenka
• Data de Publicação: 2021
• Outros Autores: Mráček, Aleš, Azevedo, Eduarda F. G., Rodrigo, M. Melia, Valente, Artur J. M., Esteso, Miguel Á., Ribeiro, Ana C. F.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/105414; https://doi.org/10.3390/pr9081433
• topic: chloroquine diphosphate; diffusion; drugs; solutions; transport properties

Mutual diffusion coefficients of chloroquine diphosphate (CDP) in aqueous solutions both without and with b-cyclodextrin (b-CD) weremeasured at concentrations from(0.0000 to 0.0100)mol dm3 and 298.15 K, using the Taylor dispersion technique. Ternary mutual diffusion coefficients (Dik) measured by the same technique are reported for aqueous CDP + b-CD solutions at 298.15 K. The presence of b CD led to relevant changes in the diffusion process, as showed by nonzero values of the cross-diffusion coefficients, D12 and D21. b-CD concentration gradients produced significant co-current coupled flows of CDP. In addition, the effects of b-CD on the transport of CDP are assessed by comparing the binary diffusion coefficient of aqueous CDP solutions with the main diffusion coefficient (D11) measured for ternary {CDP(1) + b-CD(2)} solutions. These observations are supported by viscosity analysis. All data allow to have a better interpretation on the effect of cyclodextrin on the transport behavior of CDP.