Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems

Detalhes bibliográficos
Autor(a) principal: Dias, Catarina Alexandra dos Santos
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/8944
Resumo: Tese de mestrado em Química (Química, Saúde e Nutrição), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012
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spelling Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systemsBacillusCarbohydrate based antibioticsNeuroprotectorsS. sclareoidesAmyloid fibrilsRosmarinic acidTeses de mestrado - 2012Tese de mestrado em Química (Química, Saúde e Nutrição), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012New molecules from synthetic and natural origin, capable of dealing with conditions concerning ageing and/or infection, were investigated by the following approaches: Synthesis of non-toxic alkyl 2,6-deoxy glycosides with potential antibiotic and anti-amyloidogenic activity Identification of active principles of S. sclareoides regarding its anti-amyloidogenic effects.Infections are frequently more severe in elderly population and antibiotics endorsing active and healthier ageing become relevant. Antimicrobial activity was assessed by microdilution method, and the anti-amyloidogenic activity was assessed by fibrilisation/defibrilisation of cystatin B, monitored with ThT and fluorescence spectroscopy. Moreover, plant extracts, their pure components and synthetic glycosides were added to 15N cystatin B and HSQC spectra showed binding to the protein in loop residues and β strands. The ability of synthetic compounds, extracts and pure components to prevent conversion of PrPC to PrPSc was measured by dot blot analysis. The results obtained reinforce the potential of some of the tested compounds/extracts for drug research in both ageing and infection.Rauter, Amélia Pilar, 1950-Barbosa, DáliaRepositório da Universidade de LisboaDias, Catarina Alexandra dos Santos2013-08-02T09:49:59Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/8944engmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:53:02Zoai:repositorio.ul.pt:10451/8944Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:33:17.879389Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
title Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
spellingShingle Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
Dias, Catarina Alexandra dos Santos
Bacillus
Carbohydrate based antibiotics
Neuroprotectors
S. sclareoides
Amyloid fibrils
Rosmarinic acid
Teses de mestrado - 2012
title_short Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
title_full Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
title_fullStr Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
title_full_unstemmed Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
title_sort Searching for potencial antibiotic agents of natural and synthetic origin and their interaction with amyloid fibril formation systems
author Dias, Catarina Alexandra dos Santos
author_facet Dias, Catarina Alexandra dos Santos
author_role author
dc.contributor.none.fl_str_mv Rauter, Amélia Pilar, 1950-
Barbosa, Dália
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Dias, Catarina Alexandra dos Santos
dc.subject.por.fl_str_mv Bacillus
Carbohydrate based antibiotics
Neuroprotectors
S. sclareoides
Amyloid fibrils
Rosmarinic acid
Teses de mestrado - 2012
topic Bacillus
Carbohydrate based antibiotics
Neuroprotectors
S. sclareoides
Amyloid fibrils
Rosmarinic acid
Teses de mestrado - 2012
description Tese de mestrado em Química (Química, Saúde e Nutrição), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2013-08-02T09:49:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/8944
url http://hdl.handle.net/10451/8944
dc.language.iso.fl_str_mv eng
language eng
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info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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