Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy

Detalhes bibliográficos
Autor(a) principal: Moreira, André
Data de Publicação: 2018
Outros Autores: Rodrigues, Ana Carolina Félix, Reis, Ana Catarina Almeida, Costa, Elisabete C., Ferreira, Paula, Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/6609
Resumo: Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.
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spelling Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapyCancerCombinatorial therapyDrug-deliveryGold-core silica shell nanorodsPhotothermal therapyAim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.Future MedicineuBibliorumMoreira, AndréRodrigues, Ana Carolina FélixReis, Ana Catarina AlmeidaCosta, Elisabete C.Ferreira, PaulaCorreia, Ilídio Joaquim Sobreira2018-12-11T10:05:13Z2018-102018-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/6609engMoreira, A.F., Rodrigues, C.F., Reis. C.A., Costa, E.C., Ferreira, P., Correia, I.J. (2018) "Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy", Nanomedicine, Vol. 13, Nº 2010.2217/nnm-2018-0179metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:45:18Zoai:ubibliorum.ubi.pt:10400.6/6609Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:47:17.707533Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
title Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
spellingShingle Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
Moreira, André
Cancer
Combinatorial therapy
Drug-delivery
Gold-core silica shell nanorods
Photothermal therapy
title_short Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
title_full Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
title_fullStr Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
title_full_unstemmed Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
title_sort Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy
author Moreira, André
author_facet Moreira, André
Rodrigues, Ana Carolina Félix
Reis, Ana Catarina Almeida
Costa, Elisabete C.
Ferreira, Paula
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Rodrigues, Ana Carolina Félix
Reis, Ana Catarina Almeida
Costa, Elisabete C.
Ferreira, Paula
Correia, Ilídio Joaquim Sobreira
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Moreira, André
Rodrigues, Ana Carolina Félix
Reis, Ana Catarina Almeida
Costa, Elisabete C.
Ferreira, Paula
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv Cancer
Combinatorial therapy
Drug-delivery
Gold-core silica shell nanorods
Photothermal therapy
topic Cancer
Combinatorial therapy
Drug-delivery
Gold-core silica shell nanorods
Photothermal therapy
description Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T10:05:13Z
2018-10
2018-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/6609
url http://hdl.handle.net/10400.6/6609
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moreira, A.F., Rodrigues, C.F., Reis. C.A., Costa, E.C., Ferreira, P., Correia, I.J. (2018) "Development of poly-2-ethyl-2-oxazoline coated gold-core silica shell nanorods for cancer chemo-photothermal therapy", Nanomedicine, Vol. 13, Nº 20
10.2217/nnm-2018-0179
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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