Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847 |
Resumo: | Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country. |
id |
RCAP_2841a09f34f171b84a8641ccc149c223 |
---|---|
oai_identifier_str |
oai:ojs.www.actamedicaportuguesa.com:article/16847 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese PopulationRastreio do Cancro do Pulmão: Tomografia Computadorizada Torácica de Baixa Dose Realizada numa População Portuguesa de Alto RiscoEarly Detection of CancerLung Neoplasms/diagnostic imagingTobacco/adverse effectsTomography, X-Ray ComputedUranium/adverse effectsDeteção Precoce da NeoplasiaNeoplasias do Pulmão/diagnóstico por imagemTabaco/efeitos adversosTomografia ComputorizadaUrânio/efeitos adversosIntroduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country.Introdução: As minas da Urgeiriça foram, no passado, o principal produtor de urânio em Portugal. O objetivo deste estudo foi estimar o benefício da tomografia computorizada de baixa dose (TCBD) no rastreio do cancro do pulmão em ex-mineiros considerados como grupo de alto risco.Métodos: Ex-mineiros da Companhia Nacional de Urânio com exposição a urânio e carga tabágica superior a 20 unidades maço ano, concordaram realizar uma TCBD. As recomendações da Sociedade Fleischner foram utilizadas na classificação dos nódulos e no estabelecimento do follow-up.Resultados: Duzentos e sessenta e cinco ex-trabalhadores da Companhia Nacional de Urânio foram incluídos. O tempo médio de trabalho nas minas foi 15 (0 - 45) anos. Os não-fumadores representavam 50,9%, 30,2% referiram fumar ou ter fumado e os restantes não responderam. Foi diagnosticado inicialmente um caso de cancro do pulmão. Numa segunda fase, entre os 66 ex-mineiros rastreados foram identificados 37 com nódulos pulmonares, a maioria com nódulo único (n = 13) e tamanho médio de 5 (1 - 16) mm. Um nódulo espiculado de 16 mm foi avaliado por PET/TC, e por biópsia transtorácica e cirúrgica, revelando uma lesão benigna.Conclusão: Os dados destacam a importância do rastreio em populações de alto risco. Este foi, tanto quanto é do nosso conhecimento, o primeiro estudo realizado em Portugal, e pode atuar como ponte para uma ampla implementação no país.Ordem dos Médicos2023-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847Acta Médica Portuguesa; Vol. 36 No. 9 (2023): September; 559-566Acta Médica Portuguesa; Vol. 36 N.º 9 (2023): Setembro; 559-5661646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847/15229Direitos de Autor (c) 2022 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessMoura Cabral, SaraAbreu, InêsMadama, DanielaEstevão, AméliaCordeiro, EugénioPimentel, JoãoMiranda, NunoFerreira, António JorgeRobalo Cordeiro, Carlos2023-09-03T03:00:36Zoai:ojs.www.actamedicaportuguesa.com:article/16847Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:28:12.166859Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population Rastreio do Cancro do Pulmão: Tomografia Computadorizada Torácica de Baixa Dose Realizada numa População Portuguesa de Alto Risco |
title |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population |
spellingShingle |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population Moura Cabral, Sara Early Detection of Cancer Lung Neoplasms/diagnostic imaging Tobacco/adverse effects Tomography, X-Ray Computed Uranium/adverse effects Deteção Precoce da Neoplasia Neoplasias do Pulmão/diagnóstico por imagem Tabaco/efeitos adversos Tomografia Computorizada Urânio/efeitos adversos |
title_short |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population |
title_full |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population |
title_fullStr |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population |
title_full_unstemmed |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population |
title_sort |
Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population |
author |
Moura Cabral, Sara |
author_facet |
Moura Cabral, Sara Abreu, Inês Madama, Daniela Estevão, Amélia Cordeiro, Eugénio Pimentel, João Miranda, Nuno Ferreira, António Jorge Robalo Cordeiro, Carlos |
author_role |
author |
author2 |
Abreu, Inês Madama, Daniela Estevão, Amélia Cordeiro, Eugénio Pimentel, João Miranda, Nuno Ferreira, António Jorge Robalo Cordeiro, Carlos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Moura Cabral, Sara Abreu, Inês Madama, Daniela Estevão, Amélia Cordeiro, Eugénio Pimentel, João Miranda, Nuno Ferreira, António Jorge Robalo Cordeiro, Carlos |
dc.subject.por.fl_str_mv |
Early Detection of Cancer Lung Neoplasms/diagnostic imaging Tobacco/adverse effects Tomography, X-Ray Computed Uranium/adverse effects Deteção Precoce da Neoplasia Neoplasias do Pulmão/diagnóstico por imagem Tabaco/efeitos adversos Tomografia Computorizada Urânio/efeitos adversos |
topic |
Early Detection of Cancer Lung Neoplasms/diagnostic imaging Tobacco/adverse effects Tomography, X-Ray Computed Uranium/adverse effects Deteção Precoce da Neoplasia Neoplasias do Pulmão/diagnóstico por imagem Tabaco/efeitos adversos Tomografia Computorizada Urânio/efeitos adversos |
description |
Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847/15229 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2022 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2022 Acta Médica Portuguesa |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 36 No. 9 (2023): September; 559-566 Acta Médica Portuguesa; Vol. 36 N.º 9 (2023): Setembro; 559-566 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133549905838080 |