Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population

Detalhes bibliográficos
Autor(a) principal: Moura Cabral, Sara
Data de Publicação: 2023
Outros Autores: Abreu, Inês, Madama, Daniela, Estevão, Amélia, Cordeiro, Eugénio, Pimentel, João, Miranda, Nuno, Ferreira, António Jorge, Robalo Cordeiro, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847
Resumo: Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country.
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spelling Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese PopulationRastreio do Cancro do Pulmão: Tomografia Computadorizada Torácica de Baixa Dose Realizada numa População Portuguesa de Alto RiscoEarly Detection of CancerLung Neoplasms/diagnostic imagingTobacco/adverse effectsTomography, X-Ray ComputedUranium/adverse effectsDeteção Precoce da NeoplasiaNeoplasias do Pulmão/diagnóstico por imagemTabaco/efeitos adversosTomografia ComputorizadaUrânio/efeitos adversosIntroduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country.Introdução: As minas da Urgeiriça foram, no passado, o principal produtor de urânio em Portugal. O objetivo deste estudo foi estimar o benefício da tomografia computorizada de baixa dose (TCBD) no rastreio do cancro do pulmão em ex-mineiros considerados como grupo de alto risco.Métodos: Ex-mineiros da Companhia Nacional de Urânio com exposição a urânio e carga tabágica superior a 20 unidades maço ano, concordaram realizar uma TCBD. As recomendações da Sociedade Fleischner foram utilizadas na classificação dos nódulos e no estabelecimento do follow-up.Resultados: Duzentos e sessenta e cinco ex-trabalhadores da Companhia Nacional de Urânio foram incluídos. O tempo médio de trabalho nas minas foi 15 (0 - 45) anos. Os não-fumadores representavam 50,9%, 30,2% referiram fumar ou ter fumado e os restantes não responderam. Foi diagnosticado inicialmente um caso de cancro do pulmão. Numa segunda fase, entre os 66 ex-mineiros rastreados foram identificados 37 com nódulos pulmonares, a maioria com nódulo único (n = 13) e tamanho médio de 5 (1 - 16) mm. Um nódulo espiculado de 16 mm foi avaliado por PET/TC, e por biópsia transtorácica e cirúrgica, revelando uma lesão benigna.Conclusão: Os dados destacam a importância do rastreio em populações de alto risco. Este foi, tanto quanto é do nosso conhecimento, o primeiro estudo realizado em Portugal, e pode atuar como ponte para uma ampla implementação no país.Ordem dos Médicos2023-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847Acta Médica Portuguesa; Vol. 36 No. 9 (2023): September; 559-566Acta Médica Portuguesa; Vol. 36 N.º 9 (2023): Setembro; 559-5661646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847/15229Direitos de Autor (c) 2022 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessMoura Cabral, SaraAbreu, InêsMadama, DanielaEstevão, AméliaCordeiro, EugénioPimentel, JoãoMiranda, NunoFerreira, António JorgeRobalo Cordeiro, Carlos2023-09-03T03:00:36Zoai:ojs.www.actamedicaportuguesa.com:article/16847Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:28:12.166859Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
Rastreio do Cancro do Pulmão: Tomografia Computadorizada Torácica de Baixa Dose Realizada numa População Portuguesa de Alto Risco
title Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
spellingShingle Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
Moura Cabral, Sara
Early Detection of Cancer
Lung Neoplasms/diagnostic imaging
Tobacco/adverse effects
Tomography, X-Ray Computed
Uranium/adverse effects
Deteção Precoce da Neoplasia
Neoplasias do Pulmão/diagnóstico por imagem
Tabaco/efeitos adversos
Tomografia Computorizada
Urânio/efeitos adversos
title_short Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
title_full Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
title_fullStr Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
title_full_unstemmed Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
title_sort Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
author Moura Cabral, Sara
author_facet Moura Cabral, Sara
Abreu, Inês
Madama, Daniela
Estevão, Amélia
Cordeiro, Eugénio
Pimentel, João
Miranda, Nuno
Ferreira, António Jorge
Robalo Cordeiro, Carlos
author_role author
author2 Abreu, Inês
Madama, Daniela
Estevão, Amélia
Cordeiro, Eugénio
Pimentel, João
Miranda, Nuno
Ferreira, António Jorge
Robalo Cordeiro, Carlos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura Cabral, Sara
Abreu, Inês
Madama, Daniela
Estevão, Amélia
Cordeiro, Eugénio
Pimentel, João
Miranda, Nuno
Ferreira, António Jorge
Robalo Cordeiro, Carlos
dc.subject.por.fl_str_mv Early Detection of Cancer
Lung Neoplasms/diagnostic imaging
Tobacco/adverse effects
Tomography, X-Ray Computed
Uranium/adverse effects
Deteção Precoce da Neoplasia
Neoplasias do Pulmão/diagnóstico por imagem
Tabaco/efeitos adversos
Tomografia Computorizada
Urânio/efeitos adversos
topic Early Detection of Cancer
Lung Neoplasms/diagnostic imaging
Tobacco/adverse effects
Tomography, X-Ray Computed
Uranium/adverse effects
Deteção Precoce da Neoplasia
Neoplasias do Pulmão/diagnóstico por imagem
Tabaco/efeitos adversos
Tomografia Computorizada
Urânio/efeitos adversos
description Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847/15229
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2022 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2022 Acta Médica Portuguesa
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 36 No. 9 (2023): September; 559-566
Acta Médica Portuguesa; Vol. 36 N.º 9 (2023): Setembro; 559-566
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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