Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/21902 |
Resumo: | INTRODUCTION Primary hyperparathyroidism (pHPT) is most frequently caused by a solitary adenoma. Surgical intervention has a high cure rate, particularly when associated with a fast intraoperative intact parathyroid hormone (IOPTH) assay. Aim: to evaluate the performance and accuracy when applying this technique. METHODS we conducted a retrospective study of the last 20 patients with pHPT (mean age 59, range 24-75) that had a surgical intervention in our unit. IOPTH was used in 14 patients, with dosage at 5, 10, 15 and 30 minutes after removal of the adenoma. RESULTS The localization exams had a sensitivity of >75%. The surgical procedure of choice was a unilateral dissection through a 4cm central mini-incision, with all patients experiencing a reduction of >50% of the IOPTH at 10 minutes. There were no surgical complications and the average length of the follow-up period was 11.4 months. The mean calcemia and iPTH dosage progression, from pre-surgery to the last follow-up visit, was respectively of 11 (SD1) to 9.4 (SD0.5) mg/dl and of 233.3 (SD177.5) to 57.1 (SD42) pg/ml. Symptoms improved in all patients. |
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Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatóriaSurgical treatment of primary hyperparathyroidism with intraoperative iPTH determinationFOCUSED LATERAL APPROACHSESTAMIBIADENOMAMINIMALLY INVASIVE PARATHYROIDECTOMYHORMONE ASSAY2 PREOPERATIVE LOCALIZATIONNECK EXPLORATIONREASSESSMENTEXPERIENCESURGERYINTRODUCTION Primary hyperparathyroidism (pHPT) is most frequently caused by a solitary adenoma. Surgical intervention has a high cure rate, particularly when associated with a fast intraoperative intact parathyroid hormone (IOPTH) assay. Aim: to evaluate the performance and accuracy when applying this technique. METHODS we conducted a retrospective study of the last 20 patients with pHPT (mean age 59, range 24-75) that had a surgical intervention in our unit. IOPTH was used in 14 patients, with dosage at 5, 10, 15 and 30 minutes after removal of the adenoma. RESULTS The localization exams had a sensitivity of >75%. The surgical procedure of choice was a unilateral dissection through a 4cm central mini-incision, with all patients experiencing a reduction of >50% of the IOPTH at 10 minutes. There were no surgical complications and the average length of the follow-up period was 11.4 months. The mean calcemia and iPTH dosage progression, from pre-surgery to the last follow-up visit, was respectively of 11 (SD1) to 9.4 (SD0.5) mg/dl and of 233.3 (SD177.5) to 57.1 (SD42) pg/ml. Symptoms improved in all patients.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAllen , MiguelAlmeida, IsabelTorrinha, Joaquim2017-07-10T22:01:00Z2008-012008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://hdl.handle.net/10362/21902por1646-0758PURE: 333091info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:09:01Zoai:run.unl.pt:10362/21902Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:02.033713Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória Surgical treatment of primary hyperparathyroidism with intraoperative iPTH determination |
title |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória |
spellingShingle |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória Allen , Miguel FOCUSED LATERAL APPROACH SESTAMIBI ADENOMA MINIMALLY INVASIVE PARATHYROIDECTOMY HORMONE ASSAY 2 PREOPERATIVE LOCALIZATION NECK EXPLORATION REASSESSMENT EXPERIENCE SURGERY |
title_short |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória |
title_full |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória |
title_fullStr |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória |
title_full_unstemmed |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória |
title_sort |
Tratamento cirúrgico do hiperparatiroidismo primário com pthi intra-operatória |
author |
Allen , Miguel |
author_facet |
Allen , Miguel Almeida, Isabel Torrinha, Joaquim |
author_role |
author |
author2 |
Almeida, Isabel Torrinha, Joaquim |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Allen , Miguel Almeida, Isabel Torrinha, Joaquim |
dc.subject.por.fl_str_mv |
FOCUSED LATERAL APPROACH SESTAMIBI ADENOMA MINIMALLY INVASIVE PARATHYROIDECTOMY HORMONE ASSAY 2 PREOPERATIVE LOCALIZATION NECK EXPLORATION REASSESSMENT EXPERIENCE SURGERY |
topic |
FOCUSED LATERAL APPROACH SESTAMIBI ADENOMA MINIMALLY INVASIVE PARATHYROIDECTOMY HORMONE ASSAY 2 PREOPERATIVE LOCALIZATION NECK EXPLORATION REASSESSMENT EXPERIENCE SURGERY |
description |
INTRODUCTION Primary hyperparathyroidism (pHPT) is most frequently caused by a solitary adenoma. Surgical intervention has a high cure rate, particularly when associated with a fast intraoperative intact parathyroid hormone (IOPTH) assay. Aim: to evaluate the performance and accuracy when applying this technique. METHODS we conducted a retrospective study of the last 20 patients with pHPT (mean age 59, range 24-75) that had a surgical intervention in our unit. IOPTH was used in 14 patients, with dosage at 5, 10, 15 and 30 minutes after removal of the adenoma. RESULTS The localization exams had a sensitivity of >75%. The surgical procedure of choice was a unilateral dissection through a 4cm central mini-incision, with all patients experiencing a reduction of >50% of the IOPTH at 10 minutes. There were no surgical complications and the average length of the follow-up period was 11.4 months. The mean calcemia and iPTH dosage progression, from pre-surgery to the last follow-up visit, was respectively of 11 (SD1) to 9.4 (SD0.5) mg/dl and of 233.3 (SD177.5) to 57.1 (SD42) pg/ml. Symptoms improved in all patients. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01 2008-01-01T00:00:00Z 2017-07-10T22:01:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/21902 |
url |
http://hdl.handle.net/10362/21902 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
1646-0758 PURE: 333091 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137899808030720 |