Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Ana
Data de Publicação: 2017
Outros Autores: Monteiro, Joana F., Certal, Ana C., Cristovão, Ana, Saúde, Leonor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51484
Resumo: © 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited
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spelling Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafishCSF-contacting neuronsFoxj1aShhEpendymal radial gliaSpinal cord injuryZebrafish© 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are creditedZebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of the spinal cord structure. Finally, this study reveals that Foxj1a expression in the injured spinal cord is regulated by regulatory elements activated during regeneration. These data establish Foxj1a as a pan-ependymal marker in development, homeostasis and regeneration and may help identify the signals that enable this progenitor population to replace lost cells after spinal cord injury.This research was supported by FCT (Portugal) grants (PTDC/BIM-MED/1375/2012 and PTDC/BIM-MED/3295/2014) given to L.S. L.S. was supported by an IF contract from FCT (Portugal). A.R. was supported by a postdoctoral fellowship of the FCT (Portugal) (SFRH/BPD/100162/2014) and EMBO (605-2012)The Royal SocietyRepositório da Universidade de LisboaRibeiro, AnaMonteiro, Joana F.Certal, Ana C.Cristovão, AnaSaúde, Leonor2022-02-23T16:43:52Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51484engOpen Biol. 2017 Nov;7(11):17013910.1098/rsob.1701392046-2441info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:11Zoai:repositorio.ul.pt:10451/51484Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:45.683234Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
title Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
spellingShingle Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
Ribeiro, Ana
CSF-contacting neurons
Foxj1a
Shh
Ependymal radial glia
Spinal cord injury
Zebrafish
title_short Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
title_full Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
title_fullStr Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
title_full_unstemmed Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
title_sort Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish
author Ribeiro, Ana
author_facet Ribeiro, Ana
Monteiro, Joana F.
Certal, Ana C.
Cristovão, Ana
Saúde, Leonor
author_role author
author2 Monteiro, Joana F.
Certal, Ana C.
Cristovão, Ana
Saúde, Leonor
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ribeiro, Ana
Monteiro, Joana F.
Certal, Ana C.
Cristovão, Ana
Saúde, Leonor
dc.subject.por.fl_str_mv CSF-contacting neurons
Foxj1a
Shh
Ependymal radial glia
Spinal cord injury
Zebrafish
topic CSF-contacting neurons
Foxj1a
Shh
Ependymal radial glia
Spinal cord injury
Zebrafish
description © 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2022-02-23T16:43:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51484
url http://hdl.handle.net/10451/51484
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Open Biol. 2017 Nov;7(11):170139
10.1098/rsob.170139
2046-2441
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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