Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism

Detalhes bibliográficos
Autor(a) principal: Ferreira, Flora
Data de Publicação: 2019
Outros Autores: Gago, Miguel F., Bicho, Estela, Carvalho, Catarina, Mollaei, Nafiseh, Rodrigues, Lurdes, Sousa, Nuno, Rodrigues, Pedro Pereira, Ferreira, Carlos, Gama, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62328
Resumo: Accepted Manuscript
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spelling Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular ParkinsonismVascular ParkinsonismIdiopathic Parkinson's diseaseToe and heel clearanceShort and long-term gait variabilityLevodopaCiências Médicas::Medicina BásicaScience & TechnologyAccepted ManuscriptThe literature on gait analysis in Vascular Parkinsonism (VaP), addressing issues such as variability, foot clearance patterns, and the effect of levodopa, is scarce. This study investigates whether spatiotemporal, foot clearance and stride-to-stride variability analysis can discriminate VaP, and responsiveness to levodopa. Fifteen healthy subjects, 15 Idiopathic Parkinson's Disease (IPD) patients and 15 VaP patients, were assessed in two phases: before (Off-state), and one hour after (On-state) the acute administration of a suprathreshold (1.5 times the usual) levodopa dose. Participants were asked to walk a 30-meter continuous course at a self-selected walking speed while wearing foot-worn inertial sensors. For each gait variable, mean, coefficient of variation (CV), and standard deviations SD1 and SD2 obtained by Poincaré analysis were calculated. General linear models (GLMs) were used to identify group differences. Patients were subject to neuropsychological evaluation (MoCA test) and Brain MRI. VaP patients presented lower mean stride velocity, stride length, lift-off and strike angle, and height of maximum toe (later swing) (p < .05), and higher %gait cycle in double support, with only the latter unresponsive to levodopa. VaP patients also presented higher CV, significantly reduced after levodopa. Yet, all VaP versus IPD differences lost significance when accounting for mean stride length as a covariate. In conclusion, VaP patients presented a unique gait with reduced degrees of foot clearance, probably correlated to vascular lesioning in dopaminergic/non-dopaminergic cortical and subcortical non-dopaminergic networks, still amenable to benefit from levodopa. The dependency of gait and foot clearance and variability deficits from stride length deserves future clarification.projects NORTE-01-0145-FEDER-000016 (NanoSTIMA) and NORTE-01-0145-FEDER-000026 (DeM), financed by the Regional Operational Program of the North (NORTE2020), under PORTUGAL2020 and FEDER.ElsevierUniversidade do MinhoFerreira, FloraGago, Miguel F.Bicho, EstelaCarvalho, CatarinaMollaei, NafisehRodrigues, LurdesSousa, NunoRodrigues, Pedro PereiraFerreira, CarlosGama, João20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62328engFerreira, F., Gago, M. F., et. al. (2019). Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson’s Disease and Vascular Parkinsonism. Journal of biomechanics.0021-92901873-238010.1016/j.jbiomech.2019.05.03931182234https://www.sciencedirect.com/science/article/pii/S0021929019303835info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:35:14Zoai:repositorium.sdum.uminho.pt:1822/62328Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:31:04.038380Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
title Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
spellingShingle Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
Ferreira, Flora
Vascular Parkinsonism
Idiopathic Parkinson's disease
Toe and heel clearance
Short and long-term gait variability
Levodopa
Ciências Médicas::Medicina Básica
Science & Technology
title_short Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
title_full Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
title_fullStr Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
title_full_unstemmed Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
title_sort Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson's Disease and Vascular Parkinsonism
author Ferreira, Flora
author_facet Ferreira, Flora
Gago, Miguel F.
Bicho, Estela
Carvalho, Catarina
Mollaei, Nafiseh
Rodrigues, Lurdes
Sousa, Nuno
Rodrigues, Pedro Pereira
Ferreira, Carlos
Gama, João
author_role author
author2 Gago, Miguel F.
Bicho, Estela
Carvalho, Catarina
Mollaei, Nafiseh
Rodrigues, Lurdes
Sousa, Nuno
Rodrigues, Pedro Pereira
Ferreira, Carlos
Gama, João
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ferreira, Flora
Gago, Miguel F.
Bicho, Estela
Carvalho, Catarina
Mollaei, Nafiseh
Rodrigues, Lurdes
Sousa, Nuno
Rodrigues, Pedro Pereira
Ferreira, Carlos
Gama, João
dc.subject.por.fl_str_mv Vascular Parkinsonism
Idiopathic Parkinson's disease
Toe and heel clearance
Short and long-term gait variability
Levodopa
Ciências Médicas::Medicina Básica
Science & Technology
topic Vascular Parkinsonism
Idiopathic Parkinson's disease
Toe and heel clearance
Short and long-term gait variability
Levodopa
Ciências Médicas::Medicina Básica
Science & Technology
description Accepted Manuscript
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62328
url http://hdl.handle.net/1822/62328
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ferreira, F., Gago, M. F., et. al. (2019). Gait stride-to-stride variability and foot clearance pattern analysis in Idiopathic Parkinson’s Disease and Vascular Parkinsonism. Journal of biomechanics.
0021-9290
1873-2380
10.1016/j.jbiomech.2019.05.039
31182234
https://www.sciencedirect.com/science/article/pii/S0021929019303835
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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