Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/45144 |
Resumo: | Striatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1 and D2 neurons in the nucleus accumbens (NAc) predicts motivational drive, and that optogenetic activation of either neuronal population enhances motivation in mice. Using a different approach in rats, we further show that activating NAc D2 neurons increases cue-induced motivational drive in control animals and in a model that presents anhedonia and motivational deficits; conversely, optogenetic inhibition of D2 neurons decreases motivation. Our results suggest that the classic view of D1-D2 functional antagonism does not hold true for all dimensions of reward-related behaviours, and that D2 neurons may play a more prominent pro-motivation role than originally anticipated. |
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Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation.Science & TechnologyStriatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1 and D2 neurons in the nucleus accumbens (NAc) predicts motivational drive, and that optogenetic activation of either neuronal population enhances motivation in mice. Using a different approach in rats, we further show that activating NAc D2 neurons increases cue-induced motivational drive in control animals and in a model that presents anhedonia and motivational deficits; conversely, optogenetic inhibition of D2 neurons decreases motivation. Our results suggest that the classic view of D1-D2 functional antagonism does not hold true for all dimensions of reward-related behaviours, and that D2 neurons may play a more prominent pro-motivation role than originally anticipated.A special acknowledgement to Karl Deisseroth from Stanford University, for providing viral constructs and for comments on the manuscript, and to Alan Dorval from the University of Utah, for providing mouse strains. Thanks to Luis Jacinto, Joao Oliveira and Joana Silva that helped in some technical aspects of the experiments. C.S.-C., B.C., A.D.-P. and S.B. are recipients of Fundacao para a Ciencia e Tecnologia (FCT) fellowships (SFRH/BD/51992/2012; SFRH/BD/98675/2013; SFRH/BD/90374/2012; SFRH/BD/89936/2012). A.J.R. is a FCT Investigator (IF/00883/2013). This work was co-financed by the Portuguese North Regional Operational Program (ON.2 - O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). Part of the work was supported by the Janssen Neuroscience Prize (1st edition).info:eu-repo/semantics/publishedVersionNature Publishing GroupUniversidade do MinhoCunha, Catarina SoaresCoimbra, Bárbara Guimarães SalazarPereira, Ana DavidBorges, Sónia Maria de SousaCosta, Patrício SoaresSousa, NunoRodrigues, Ana JoãoPinto, Luisa2016-06-072016-06-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/45144eng2041-172310.1038/ncomms1182927337658http://www.nature.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:16:13Zoai:repositorium.sdum.uminho.pt:1822/45144Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:44.831416Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
title |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
spellingShingle |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. Cunha, Catarina Soares Science & Technology |
title_short |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
title_full |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
title_fullStr |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
title_full_unstemmed |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
title_sort |
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. |
author |
Cunha, Catarina Soares |
author_facet |
Cunha, Catarina Soares Coimbra, Bárbara Guimarães Salazar Pereira, Ana David Borges, Sónia Maria de Sousa Costa, Patrício Soares Sousa, Nuno Rodrigues, Ana João Pinto, Luisa |
author_role |
author |
author2 |
Coimbra, Bárbara Guimarães Salazar Pereira, Ana David Borges, Sónia Maria de Sousa Costa, Patrício Soares Sousa, Nuno Rodrigues, Ana João Pinto, Luisa |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cunha, Catarina Soares Coimbra, Bárbara Guimarães Salazar Pereira, Ana David Borges, Sónia Maria de Sousa Costa, Patrício Soares Sousa, Nuno Rodrigues, Ana João Pinto, Luisa |
dc.subject.por.fl_str_mv |
Science & Technology |
topic |
Science & Technology |
description |
Striatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1 and D2 neurons in the nucleus accumbens (NAc) predicts motivational drive, and that optogenetic activation of either neuronal population enhances motivation in mice. Using a different approach in rats, we further show that activating NAc D2 neurons increases cue-induced motivational drive in control animals and in a model that presents anhedonia and motivational deficits; conversely, optogenetic inhibition of D2 neurons decreases motivation. Our results suggest that the classic view of D1-D2 functional antagonism does not hold true for all dimensions of reward-related behaviours, and that D2 neurons may play a more prominent pro-motivation role than originally anticipated. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-07 2016-06-07T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/45144 |
url |
http://hdl.handle.net/1822/45144 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2041-1723 10.1038/ncomms11829 27337658 http://www.nature.com/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132510394777600 |