Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2024 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/164516 |
Resumo: | Funding Information: EP acknowledges support from national funds through FCT ( Foundation for Science and Technology ) within the scope of Base Funding UIDB/04423/2020 and UIDP/04423/2020 ( CIIMAR ). Funding Information: IL, FG, TC acknowledge funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), as well as iNOVA4Health [UIDB/04462/2020 and UIDP/04462/2020] and LS4FUTURE [LA/P/0087/2020] programs financially supported by FCT and the Ministério da Ciência, Tecnologia e Ensino Superior ( MCTES ). Funding Information: PR acknowledges financial support Grant PID2021-126132NB-I00 by MCIN/ AEI / 10.13039/501100011033 and the NMR Service of CEQMA (CSIC-UZ). Funding Information: SM acknowledges financial support from Fundação para a Ciência e a Tecnologia ( FCT ), Portugal for PhD grant SFRH/ BD / 146967/2019 . Funding Information: VS acknowledges financial support Grant PID2021-127847OB-I00 and PDC2022-133866-I00 by MCIN/AEI , as well the ELECMI (LMA node) and NANBIOSIS ICTSs. Funding Information: This research was supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT / MCTES ( UIDB/50006/2020 and UIDP/50006/2020 ). Publisher Copyright: © 2024 The Authors |
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Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activitiesAntimicrobial propertiesDelivery systemsHydrophobic deep eutectic solventNanoemulsionsNatural compoundsNMR analysisRenewable Energy, Sustainability and the EnvironmentEnvironmental Science(all)Strategy and ManagementIndustrial and Manufacturing EngineeringSDG 7 - Affordable and Clean EnergyFunding Information: EP acknowledges support from national funds through FCT ( Foundation for Science and Technology ) within the scope of Base Funding UIDB/04423/2020 and UIDP/04423/2020 ( CIIMAR ). Funding Information: IL, FG, TC acknowledge funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), as well as iNOVA4Health [UIDB/04462/2020 and UIDP/04462/2020] and LS4FUTURE [LA/P/0087/2020] programs financially supported by FCT and the Ministério da Ciência, Tecnologia e Ensino Superior ( MCTES ). Funding Information: PR acknowledges financial support Grant PID2021-126132NB-I00 by MCIN/ AEI / 10.13039/501100011033 and the NMR Service of CEQMA (CSIC-UZ). Funding Information: SM acknowledges financial support from Fundação para a Ciência e a Tecnologia ( FCT ), Portugal for PhD grant SFRH/ BD / 146967/2019 . Funding Information: VS acknowledges financial support Grant PID2021-127847OB-I00 and PDC2022-133866-I00 by MCIN/AEI , as well the ELECMI (LMA node) and NANBIOSIS ICTSs. Funding Information: This research was supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT / MCTES ( UIDB/50006/2020 and UIDP/50006/2020 ). Publisher Copyright: © 2024 The AuthorsHydrophobic deep eutectic solvents (DESs), a recent class of green solvents, offer 100% atom economy, low cost, potential biodegradability, negligible toxicity and promising bioactivities. In this work, novel aroma-based therapeutic hydrophobic DESs were prepared and dispersed in aqueous media as nanoemulsions to potentiate biomedical applications, where polar media is encountered. A reusable microengineered stainless-steel isoporous membrane was fabricated by laser drilling technique. Three hydrophobic DESs, namely DES A (menthol and vanillin), DES B (menthol and raspberry ketone), and DES C (thymol and raspberry ketone) were prepared and emulsified in aqueous media by sustainable membrane emulsification technique. The optimised nanoemulsion (DES C-in-water) exhibited a monomodal size distribution with Zavg (size average) of 147 nm and polydispersity index of 0.22. From the application perspective, the formulated DES-in-water nanoemulsions and their constituents were evaluated for their antibacterial properties against Escherichia coli and Staphylococcus aureus. Additionally, antifungal properties of the DES-based emulsions were reported for the first time by testing them against four fungal strains, Aspergillus fumigatus, Candida albicans, Candida krusei, and Trichophyton mentagrophytes. The nanoemulsions were found to be exhibit antimicrobial effect and lesser quantities of individual compounds were needed in nanoemulsified state to show similar effects. Different 1D and 2D NMR techniques were successfully used to investigate the structural orientation and the inter and intramolecular interactions in the DES and emulsion systems, which revealed a probable cause for higher antimicrobial activity of DES C-based emulsions compared to its peers. Lastly, a synergistic effect of the components in nanoemulsions led to enhanced antimicrobial activities.DQ - Departamento de QuímicaLAQV@REQUIMTEInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNMondal, S.Syed, U. T.Pinto, E.Leonardo, I. C.Romero, P.Gaspar, F. B.Crespo, M. T. BarretoSebastian, V.Crespo, J. G.Brazinha, C.2024-03-06T00:23:29Z2024-03-102024-03-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/164516eng0959-6526PURE: 84620847https://doi.org/10.1016/j.jclepro.2024.141167info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:52:49Zoai:run.unl.pt:10362/164516Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:13.543199Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| title |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| spellingShingle |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities Mondal, S. Antimicrobial properties Delivery systems Hydrophobic deep eutectic solvent Nanoemulsions Natural compounds NMR analysis Renewable Energy, Sustainability and the Environment Environmental Science(all) Strategy and Management Industrial and Manufacturing Engineering SDG 7 - Affordable and Clean Energy |
| title_short |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| title_full |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| title_fullStr |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| title_full_unstemmed |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| title_sort |
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities |
| author |
Mondal, S. |
| author_facet |
Mondal, S. Syed, U. T. Pinto, E. Leonardo, I. C. Romero, P. Gaspar, F. B. Crespo, M. T. Barreto Sebastian, V. Crespo, J. G. Brazinha, C. |
| author_role |
author |
| author2 |
Syed, U. T. Pinto, E. Leonardo, I. C. Romero, P. Gaspar, F. B. Crespo, M. T. Barreto Sebastian, V. Crespo, J. G. Brazinha, C. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DQ - Departamento de Química LAQV@REQUIMTE Instituto de Tecnologia Química e Biológica António Xavier (ITQB) RUN |
| dc.contributor.author.fl_str_mv |
Mondal, S. Syed, U. T. Pinto, E. Leonardo, I. C. Romero, P. Gaspar, F. B. Crespo, M. T. Barreto Sebastian, V. Crespo, J. G. Brazinha, C. |
| dc.subject.por.fl_str_mv |
Antimicrobial properties Delivery systems Hydrophobic deep eutectic solvent Nanoemulsions Natural compounds NMR analysis Renewable Energy, Sustainability and the Environment Environmental Science(all) Strategy and Management Industrial and Manufacturing Engineering SDG 7 - Affordable and Clean Energy |
| topic |
Antimicrobial properties Delivery systems Hydrophobic deep eutectic solvent Nanoemulsions Natural compounds NMR analysis Renewable Energy, Sustainability and the Environment Environmental Science(all) Strategy and Management Industrial and Manufacturing Engineering SDG 7 - Affordable and Clean Energy |
| description |
Funding Information: EP acknowledges support from national funds through FCT ( Foundation for Science and Technology ) within the scope of Base Funding UIDB/04423/2020 and UIDP/04423/2020 ( CIIMAR ). Funding Information: IL, FG, TC acknowledge funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), as well as iNOVA4Health [UIDB/04462/2020 and UIDP/04462/2020] and LS4FUTURE [LA/P/0087/2020] programs financially supported by FCT and the Ministério da Ciência, Tecnologia e Ensino Superior ( MCTES ). Funding Information: PR acknowledges financial support Grant PID2021-126132NB-I00 by MCIN/ AEI / 10.13039/501100011033 and the NMR Service of CEQMA (CSIC-UZ). Funding Information: SM acknowledges financial support from Fundação para a Ciência e a Tecnologia ( FCT ), Portugal for PhD grant SFRH/ BD / 146967/2019 . Funding Information: VS acknowledges financial support Grant PID2021-127847OB-I00 and PDC2022-133866-I00 by MCIN/AEI , as well the ELECMI (LMA node) and NANBIOSIS ICTSs. Funding Information: This research was supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT / MCTES ( UIDB/50006/2020 and UIDP/50006/2020 ). Publisher Copyright: © 2024 The Authors |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-03-06T00:23:29Z 2024-03-10 2024-03-10T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/164516 |
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http://hdl.handle.net/10362/164516 |
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eng |
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eng |
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0959-6526 PURE: 84620847 https://doi.org/10.1016/j.jclepro.2024.141167 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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13 application/pdf |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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