Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4122 |
Resumo: | Introduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation. Mixed effects regression models were used for analysis. Results: Fifty-six patients with a mean age of 53.7 (8.5) years were included; 87.5% were males. In T0, 41% of patients were normometabolic, 37.5% were hypometabolic and 21.4% were hypermetabolic. After transplantation, the mean REE decreased progressively in patients initially hypermetabolic and the opposite occurred in those initially hypometabolic. The REE evolution was positively associated with body weight (β = 9.6, p < 0.001) and energy intake (β= 13.6, p = 0.005) in the whole sample; it was positively associated with body weight (β= 7.1, p = 0.018) and percentage of energy intake from lipids (β= 18.9, p = 0.003) in initially hypometabolic patients, and positively associated with body weight (β= 14.1, p < 0.001) and negatively associated with SGA-undernourishment (β = -171, p = 0.007) in initially normometabolic patients. Conclusion: Different REE evolutions after liver transplantation are associated with the preoperative metabolic status. In patients initially hypometabolic, the REE evolution is positively associated with body weight and percentage of energy intake from lipids, and in those initially normometabolic, it is positively associated with body weight and negatively associated with SGA-undernourishment. |
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Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in AdultsInfluencia del Estado Metabólico Preoperatorio sobre los Cambios en el Gasto Energético en Reposo después del Transplante Hepático en AdultosHCC DIECHLC CINVHCC CHBPTMaleFemaleHumansMiddle AgedBody CompositionCohort StudiesEnd Stage Liver Disease / metabolismEnd Stage Liver Disease / surgeryEnergy Metabolism / physiology*Liver Transplantation*Longitudinal StudiesNutrition AssessmentNutritional Status*Nutritional SupportPreoperative PeriodIntroduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation. Mixed effects regression models were used for analysis. Results: Fifty-six patients with a mean age of 53.7 (8.5) years were included; 87.5% were males. In T0, 41% of patients were normometabolic, 37.5% were hypometabolic and 21.4% were hypermetabolic. After transplantation, the mean REE decreased progressively in patients initially hypermetabolic and the opposite occurred in those initially hypometabolic. The REE evolution was positively associated with body weight (β = 9.6, p < 0.001) and energy intake (β= 13.6, p = 0.005) in the whole sample; it was positively associated with body weight (β= 7.1, p = 0.018) and percentage of energy intake from lipids (β= 18.9, p = 0.003) in initially hypometabolic patients, and positively associated with body weight (β= 14.1, p < 0.001) and negatively associated with SGA-undernourishment (β = -171, p = 0.007) in initially normometabolic patients. Conclusion: Different REE evolutions after liver transplantation are associated with the preoperative metabolic status. In patients initially hypometabolic, the REE evolution is positively associated with body weight and percentage of energy intake from lipids, and in those initially normometabolic, it is positively associated with body weight and negatively associated with SGA-undernourishment.Arán EdicionesRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEBrito-Costa, APereira-da-Silva, LPapoila, ALAlves, MMateus, ENolasco, FBarroso, E2022-06-17T14:23:04Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4122engNutr Hosp. 2017 Oct 24;34(5):1024-1032.10.20960/nh.1051.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:45:25Zoai:repositorio.chlc.min-saude.pt:10400.17/4122Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:27.874338Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults Influencia del Estado Metabólico Preoperatorio sobre los Cambios en el Gasto Energético en Reposo después del Transplante Hepático en Adultos |
title |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults |
spellingShingle |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults Brito-Costa, A HCC DIE CHLC CINV HCC CHBPT Male Female Humans Middle Aged Body Composition Cohort Studies End Stage Liver Disease / metabolism End Stage Liver Disease / surgery Energy Metabolism / physiology* Liver Transplantation* Longitudinal Studies Nutrition Assessment Nutritional Status* Nutritional Support Preoperative Period |
title_short |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults |
title_full |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults |
title_fullStr |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults |
title_full_unstemmed |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults |
title_sort |
Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults |
author |
Brito-Costa, A |
author_facet |
Brito-Costa, A Pereira-da-Silva, L Papoila, AL Alves, M Mateus, E Nolasco, F Barroso, E |
author_role |
author |
author2 |
Pereira-da-Silva, L Papoila, AL Alves, M Mateus, E Nolasco, F Barroso, E |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Brito-Costa, A Pereira-da-Silva, L Papoila, AL Alves, M Mateus, E Nolasco, F Barroso, E |
dc.subject.por.fl_str_mv |
HCC DIE CHLC CINV HCC CHBPT Male Female Humans Middle Aged Body Composition Cohort Studies End Stage Liver Disease / metabolism End Stage Liver Disease / surgery Energy Metabolism / physiology* Liver Transplantation* Longitudinal Studies Nutrition Assessment Nutritional Status* Nutritional Support Preoperative Period |
topic |
HCC DIE CHLC CINV HCC CHBPT Male Female Humans Middle Aged Body Composition Cohort Studies End Stage Liver Disease / metabolism End Stage Liver Disease / surgery Energy Metabolism / physiology* Liver Transplantation* Longitudinal Studies Nutrition Assessment Nutritional Status* Nutritional Support Preoperative Period |
description |
Introduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation. Mixed effects regression models were used for analysis. Results: Fifty-six patients with a mean age of 53.7 (8.5) years were included; 87.5% were males. In T0, 41% of patients were normometabolic, 37.5% were hypometabolic and 21.4% were hypermetabolic. After transplantation, the mean REE decreased progressively in patients initially hypermetabolic and the opposite occurred in those initially hypometabolic. The REE evolution was positively associated with body weight (β = 9.6, p < 0.001) and energy intake (β= 13.6, p = 0.005) in the whole sample; it was positively associated with body weight (β= 7.1, p = 0.018) and percentage of energy intake from lipids (β= 18.9, p = 0.003) in initially hypometabolic patients, and positively associated with body weight (β= 14.1, p < 0.001) and negatively associated with SGA-undernourishment (β = -171, p = 0.007) in initially normometabolic patients. Conclusion: Different REE evolutions after liver transplantation are associated with the preoperative metabolic status. In patients initially hypometabolic, the REE evolution is positively associated with body weight and percentage of energy intake from lipids, and in those initially normometabolic, it is positively associated with body weight and negatively associated with SGA-undernourishment. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2022-06-17T14:23:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4122 |
url |
http://hdl.handle.net/10400.17/4122 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutr Hosp. 2017 Oct 24;34(5):1024-1032. 10.20960/nh.1051. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Arán Ediciones |
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Arán Ediciones |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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