Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults

Detalhes bibliográficos
Autor(a) principal: Brito-Costa, A
Data de Publicação: 2017
Outros Autores: Pereira-da-Silva, L, Papoila, AL, Alves, M, Mateus, E, Nolasco, F, Barroso, E
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4122
Resumo: Introduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation. Mixed effects regression models were used for analysis. Results: Fifty-six patients with a mean age of 53.7 (8.5) years were included; 87.5% were males. In T0, 41% of patients were normometabolic, 37.5% were hypometabolic and 21.4% were hypermetabolic. After transplantation, the mean REE decreased progressively in patients initially hypermetabolic and the opposite occurred in those initially hypometabolic. The REE evolution was positively associated with body weight (β = 9.6, p < 0.001) and energy intake (β= 13.6, p = 0.005) in the whole sample; it was positively associated with body weight (β= 7.1, p = 0.018) and percentage of energy intake from lipids (β= 18.9, p = 0.003) in initially hypometabolic patients, and positively associated with body weight (β= 14.1, p < 0.001) and negatively associated with SGA-undernourishment (β = -171, p = 0.007) in initially normometabolic patients. Conclusion: Different REE evolutions after liver transplantation are associated with the preoperative metabolic status. In patients initially hypometabolic, the REE evolution is positively associated with body weight and percentage of energy intake from lipids, and in those initially normometabolic, it is positively associated with body weight and negatively associated with SGA-undernourishment.
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spelling Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in AdultsInfluencia del Estado Metabólico Preoperatorio sobre los Cambios en el Gasto Energético en Reposo después del Transplante Hepático en AdultosHCC DIECHLC CINVHCC CHBPTMaleFemaleHumansMiddle AgedBody CompositionCohort StudiesEnd Stage Liver Disease / metabolismEnd Stage Liver Disease / surgeryEnergy Metabolism / physiology*Liver Transplantation*Longitudinal StudiesNutrition AssessmentNutritional Status*Nutritional SupportPreoperative PeriodIntroduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation. Mixed effects regression models were used for analysis. Results: Fifty-six patients with a mean age of 53.7 (8.5) years were included; 87.5% were males. In T0, 41% of patients were normometabolic, 37.5% were hypometabolic and 21.4% were hypermetabolic. After transplantation, the mean REE decreased progressively in patients initially hypermetabolic and the opposite occurred in those initially hypometabolic. The REE evolution was positively associated with body weight (β = 9.6, p < 0.001) and energy intake (β= 13.6, p = 0.005) in the whole sample; it was positively associated with body weight (β= 7.1, p = 0.018) and percentage of energy intake from lipids (β= 18.9, p = 0.003) in initially hypometabolic patients, and positively associated with body weight (β= 14.1, p < 0.001) and negatively associated with SGA-undernourishment (β = -171, p = 0.007) in initially normometabolic patients. Conclusion: Different REE evolutions after liver transplantation are associated with the preoperative metabolic status. In patients initially hypometabolic, the REE evolution is positively associated with body weight and percentage of energy intake from lipids, and in those initially normometabolic, it is positively associated with body weight and negatively associated with SGA-undernourishment.Arán EdicionesRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEBrito-Costa, APereira-da-Silva, LPapoila, ALAlves, MMateus, ENolasco, FBarroso, E2022-06-17T14:23:04Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4122engNutr Hosp. 2017 Oct 24;34(5):1024-1032.10.20960/nh.1051.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:45:25Zoai:repositorio.chlc.min-saude.pt:10400.17/4122Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:27.874338Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
Influencia del Estado Metabólico Preoperatorio sobre los Cambios en el Gasto Energético en Reposo después del Transplante Hepático en Adultos
title Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
spellingShingle Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
Brito-Costa, A
HCC DIE
CHLC CINV
HCC CHBPT
Male
Female
Humans
Middle Aged
Body Composition
Cohort Studies
End Stage Liver Disease / metabolism
End Stage Liver Disease / surgery
Energy Metabolism / physiology*
Liver Transplantation*
Longitudinal Studies
Nutrition Assessment
Nutritional Status*
Nutritional Support
Preoperative Period
title_short Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
title_full Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
title_fullStr Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
title_full_unstemmed Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
title_sort Preoperative Metabolic Status Is Associated with Different Evolution of Resting Energy Expenditure after Liver Transplant in Adults
author Brito-Costa, A
author_facet Brito-Costa, A
Pereira-da-Silva, L
Papoila, AL
Alves, M
Mateus, E
Nolasco, F
Barroso, E
author_role author
author2 Pereira-da-Silva, L
Papoila, AL
Alves, M
Mateus, E
Nolasco, F
Barroso, E
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Brito-Costa, A
Pereira-da-Silva, L
Papoila, AL
Alves, M
Mateus, E
Nolasco, F
Barroso, E
dc.subject.por.fl_str_mv HCC DIE
CHLC CINV
HCC CHBPT
Male
Female
Humans
Middle Aged
Body Composition
Cohort Studies
End Stage Liver Disease / metabolism
End Stage Liver Disease / surgery
Energy Metabolism / physiology*
Liver Transplantation*
Longitudinal Studies
Nutrition Assessment
Nutritional Status*
Nutritional Support
Preoperative Period
topic HCC DIE
CHLC CINV
HCC CHBPT
Male
Female
Humans
Middle Aged
Body Composition
Cohort Studies
End Stage Liver Disease / metabolism
End Stage Liver Disease / surgery
Energy Metabolism / physiology*
Liver Transplantation*
Longitudinal Studies
Nutrition Assessment
Nutritional Status*
Nutritional Support
Preoperative Period
description Introduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation. Mixed effects regression models were used for analysis. Results: Fifty-six patients with a mean age of 53.7 (8.5) years were included; 87.5% were males. In T0, 41% of patients were normometabolic, 37.5% were hypometabolic and 21.4% were hypermetabolic. After transplantation, the mean REE decreased progressively in patients initially hypermetabolic and the opposite occurred in those initially hypometabolic. The REE evolution was positively associated with body weight (β = 9.6, p < 0.001) and energy intake (β= 13.6, p = 0.005) in the whole sample; it was positively associated with body weight (β= 7.1, p = 0.018) and percentage of energy intake from lipids (β= 18.9, p = 0.003) in initially hypometabolic patients, and positively associated with body weight (β= 14.1, p < 0.001) and negatively associated with SGA-undernourishment (β = -171, p = 0.007) in initially normometabolic patients. Conclusion: Different REE evolutions after liver transplantation are associated with the preoperative metabolic status. In patients initially hypometabolic, the REE evolution is positively associated with body weight and percentage of energy intake from lipids, and in those initially normometabolic, it is positively associated with body weight and negatively associated with SGA-undernourishment.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2022-06-17T14:23:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4122
url http://hdl.handle.net/10400.17/4122
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nutr Hosp. 2017 Oct 24;34(5):1024-1032.
10.20960/nh.1051.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Arán Ediciones
publisher.none.fl_str_mv Arán Ediciones
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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