Chitosan microparticles as injectable scaffolds for tissue engineering

Detalhes bibliográficos
Autor(a) principal: Garcia Cruz, Dunia M.
Data de Publicação: 2008
Outros Autores: Escobar Ivirico, J. L., Gomes, Manuela M., Gómez Ribelles, J. L., Salmerón-Sánchez, M., Reis, R. L., Mano, J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/20840
Resumo: The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine.
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spelling Chitosan microparticles as injectable scaffolds for tissue engineeringChitosan microparticlesInjectable scaffoldsStem cellsTissue engineeringMinimally invasive surgical proceduresScience & TechnologyThe use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine.Support from the Generalitat Valenciana through a short-term fellowship (No. BEFPI/2007/012) is kindly acknowledged. D.M.G.C. and J.L.G.R. acknowledge the support of the Spanish Ministry of Science through Project No. MAT2007-66759-C03-01 (including FEDER financial support). This work was also partially supported by the European Union-funded STREP Project HIPPOCRATES (NMP3-CT-2003-505758), and the European NoE EXPERTISSUES (NMP3-CT-2004-500283).WileyUniversidade do MinhoGarcia Cruz, Dunia M.Escobar Ivirico, J. L.Gomes, Manuela M.Gómez Ribelles, J. L.Salmerón-Sánchez, M.Reis, R. L.Mano, J. F.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20840eng1932-700510.1002/term.10618615778http://onlinelibrary.wiley.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:58:20Zoai:repositorium.sdum.uminho.pt:1822/20840Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:48:03.688432Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chitosan microparticles as injectable scaffolds for tissue engineering
title Chitosan microparticles as injectable scaffolds for tissue engineering
spellingShingle Chitosan microparticles as injectable scaffolds for tissue engineering
Garcia Cruz, Dunia M.
Chitosan microparticles
Injectable scaffolds
Stem cells
Tissue engineering
Minimally invasive surgical procedures
Science & Technology
title_short Chitosan microparticles as injectable scaffolds for tissue engineering
title_full Chitosan microparticles as injectable scaffolds for tissue engineering
title_fullStr Chitosan microparticles as injectable scaffolds for tissue engineering
title_full_unstemmed Chitosan microparticles as injectable scaffolds for tissue engineering
title_sort Chitosan microparticles as injectable scaffolds for tissue engineering
author Garcia Cruz, Dunia M.
author_facet Garcia Cruz, Dunia M.
Escobar Ivirico, J. L.
Gomes, Manuela M.
Gómez Ribelles, J. L.
Salmerón-Sánchez, M.
Reis, R. L.
Mano, J. F.
author_role author
author2 Escobar Ivirico, J. L.
Gomes, Manuela M.
Gómez Ribelles, J. L.
Salmerón-Sánchez, M.
Reis, R. L.
Mano, J. F.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Garcia Cruz, Dunia M.
Escobar Ivirico, J. L.
Gomes, Manuela M.
Gómez Ribelles, J. L.
Salmerón-Sánchez, M.
Reis, R. L.
Mano, J. F.
dc.subject.por.fl_str_mv Chitosan microparticles
Injectable scaffolds
Stem cells
Tissue engineering
Minimally invasive surgical procedures
Science & Technology
topic Chitosan microparticles
Injectable scaffolds
Stem cells
Tissue engineering
Minimally invasive surgical procedures
Science & Technology
description The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/20840
url http://hdl.handle.net/1822/20840
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-7005
10.1002/term.106
18615778
http://onlinelibrary.wiley.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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