Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/948 |
Resumo: | The synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy). |
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Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agentsGlycoconjugatesLanthanidesLectinsMacrocyclesMagnetic resonance imagingScience & TechnologyThe synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy).WileyUniversidade do MinhoAndré, João P.Geraldes, Carlos F. G. C.Martins, J. A. R.Merbach, André E.Prata, M. I. M.Santos, A. C.Lima, J. J. Pedroso deTóth, Éva20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/948engANDRÉ, João P. [et al.] - Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents. “Chemistry : a european journal” [Em linha]. 10:22 (2004) 5804-5816. [Consult. 30 Mar. 2005]. Disponível em: http://www3.interscience.wiley.com/cgi-bin/jissue/1097441340947-653910.1002/chem.20040018715472943info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:17:14Zoai:repositorium.sdum.uminho.pt:1822/948Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:09:49.229292Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
title |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
spellingShingle |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents André, João P. Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging Science & Technology |
title_short |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
title_full |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
title_fullStr |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
title_full_unstemmed |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
title_sort |
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents |
author |
André, João P. |
author_facet |
André, João P. Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
author_role |
author |
author2 |
Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
André, João P. Geraldes, Carlos F. G. C. Martins, J. A. R. Merbach, André E. Prata, M. I. M. Santos, A. C. Lima, J. J. Pedroso de Tóth, Éva |
dc.subject.por.fl_str_mv |
Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging Science & Technology |
topic |
Glycoconjugates Lanthanides Lectins Macrocycles Magnetic resonance imaging Science & Technology |
description |
The synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square antiprismatic geometry of the DOTA chelating moiety and fast rotation about the amide bond connecting to the targeting glycodendrimer. The in vitro relaxivity of the Gd(III)-glycoconjugates was studied by proton nuclear magnetic relaxation dispersion (NMRD), yielding parameters close to those reported for other DOTA monoamides. The known recognition of sugars by lectins makes these glycoconjugates good candidates for medical imaging agents (MRI and gamma scintigraphy). |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 2004-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/948 |
url |
http://hdl.handle.net/1822/948 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ANDRÉ, João P. [et al.] - Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of lectin-mediated medical imaging agents. “Chemistry : a european journal” [Em linha]. 10:22 (2004) 5804-5816. [Consult. 30 Mar. 2005]. Disponível em: http://www3.interscience.wiley.com/cgi-bin/jissue/109744134 0947-6539 10.1002/chem.200400187 15472943 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132524718325760 |