In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering

Detalhes bibliográficos
Autor(a) principal: Lee, Sang Jin
Data de Publicação: 2019
Outros Autores: Kim, Han-Jun, Heo, Min, Lee, Hye-Rim, Choi, Eun-Ji, Kim, Hyosung, Lee, Donghyun, Reis, R. L., Do, Sun Hee, Kwon, Il Keun
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62437
Resumo: In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.
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spelling In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineeringElectrospinningGelatinHighly aligned nanofiberPolycaprolactoneTendon tissue engineering applicationsScience & TechnologyIn this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by the Korean government (MSIP&MOHW) (No. 2017M3A9E4048170).ElsevierUniversidade do MinhoLee, Sang JinKim, Han-JunHeo, MinLee, Hye-RimChoi, Eun-JiKim, HyosungLee, DonghyunReis, R. L.Do, Sun HeeKwon, Il Keun2019-032019-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62437engLee S. J., Kim H. - J., Heo M., Lee H. - R., Choi E. - J., Kim H., Lee D., Reis R. L., Do S. H., Kwon I. K. In vitro and In vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for achilles tendon tissue engineering, Journal of Industrial and Engineering Chemistry, Vol. 76, pp. 173-180, doi:10.1016/j.jiec.2019.03.036, 20191226-086X10.1016/j.jiec.2019.03.036https://www.sciencedirect.com/science/article/pii/S1226086X19301236info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:12Zoai:repositorium.sdum.uminho.pt:1822/62437Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:07.661480Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
title In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
spellingShingle In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
Lee, Sang Jin
Electrospinning
Gelatin
Highly aligned nanofiber
Polycaprolactone
Tendon tissue engineering applications
Science & Technology
title_short In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
title_full In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
title_fullStr In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
title_full_unstemmed In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
title_sort In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
author Lee, Sang Jin
author_facet Lee, Sang Jin
Kim, Han-Jun
Heo, Min
Lee, Hye-Rim
Choi, Eun-Ji
Kim, Hyosung
Lee, Donghyun
Reis, R. L.
Do, Sun Hee
Kwon, Il Keun
author_role author
author2 Kim, Han-Jun
Heo, Min
Lee, Hye-Rim
Choi, Eun-Ji
Kim, Hyosung
Lee, Donghyun
Reis, R. L.
Do, Sun Hee
Kwon, Il Keun
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Lee, Sang Jin
Kim, Han-Jun
Heo, Min
Lee, Hye-Rim
Choi, Eun-Ji
Kim, Hyosung
Lee, Donghyun
Reis, R. L.
Do, Sun Hee
Kwon, Il Keun
dc.subject.por.fl_str_mv Electrospinning
Gelatin
Highly aligned nanofiber
Polycaprolactone
Tendon tissue engineering applications
Science & Technology
topic Electrospinning
Gelatin
Highly aligned nanofiber
Polycaprolactone
Tendon tissue engineering applications
Science & Technology
description In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.
publishDate 2019
dc.date.none.fl_str_mv 2019-03
2019-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62437
url http://hdl.handle.net/1822/62437
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lee S. J., Kim H. - J., Heo M., Lee H. - R., Choi E. - J., Kim H., Lee D., Reis R. L., Do S. H., Kwon I. K. In vitro and In vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for achilles tendon tissue engineering, Journal of Industrial and Engineering Chemistry, Vol. 76, pp. 173-180, doi:10.1016/j.jiec.2019.03.036, 2019
1226-086X
10.1016/j.jiec.2019.03.036
https://www.sciencedirect.com/science/article/pii/S1226086X19301236
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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