Renal regeneration after acute kidney injury.

Detalhes bibliográficos
Autor(a) principal: Coelho, S
Data de Publicação: 2018
Outros Autores: Cabral, G, Lopes, J, Jacinto, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/2124
Resumo: Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role, first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal haemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.
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spelling Renal regeneration after acute kidney injury.Acute kidney injuryRegenerationAcute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role, first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal haemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.WileyRepositório do Hospital Prof. Doutor Fernando FonsecaCoelho, SCabral, GLopes, JJacinto, A2019-02-18T17:17:20Z2018-01-01T00:00:00Z2018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/2124engNephrology (Carlton). 2018 Sep;23(9):805-814.1440-179710.1111/nep.13256.metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:50Zoai:repositorio.hff.min-saude.pt:10400.10/2124Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:53:06.773626Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Renal regeneration after acute kidney injury.
title Renal regeneration after acute kidney injury.
spellingShingle Renal regeneration after acute kidney injury.
Coelho, S
Acute kidney injury
Regeneration
title_short Renal regeneration after acute kidney injury.
title_full Renal regeneration after acute kidney injury.
title_fullStr Renal regeneration after acute kidney injury.
title_full_unstemmed Renal regeneration after acute kidney injury.
title_sort Renal regeneration after acute kidney injury.
author Coelho, S
author_facet Coelho, S
Cabral, G
Lopes, J
Jacinto, A
author_role author
author2 Cabral, G
Lopes, J
Jacinto, A
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Coelho, S
Cabral, G
Lopes, J
Jacinto, A
dc.subject.por.fl_str_mv Acute kidney injury
Regeneration
topic Acute kidney injury
Regeneration
description Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role, first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal haemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01T00:00:00Z
2018-01-01T00:00:00Z
2019-02-18T17:17:20Z
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nephrology (Carlton). 2018 Sep;23(9):805-814.
1440-1797
10.1111/nep.13256.
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