Schmidt’s syndrome – a clinical case

Detalhes bibliográficos
Autor(a) principal: N. Raposo, José
Data de Publicação: 2004
Outros Autores: Sousa, Susana, Namora, João, Tomaz, Aurora, Raimundo, Luísa, Fernandes, Carlos, Ferreira, José M.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/1764
Resumo: A 43-year-old woman was admitted because of nausea, vomiting, weakness and weight loss. On examination hypotension and cutaneous hyperpigmentation were detected. The sodium level was very low. Those findings suggested adrenal failure. The diagnosis of Addison disease was made because of low levels of cortisol and high levels of adrenocorticotropic hormone. Mild elevation of thyroid-stimulating hormone, normal levels of free thyroxine and free iodothyronine, associated to high levels of antithyroid antibodies, suggested chronic lymphocytic thyroiditis. The association beteween Addison disease and autoimmune thyroid disease is the hallmark of Schmidt’s syndrome. The patient showed a positive evolution after the beginning of glucocorticoid replacement therapy.
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spelling Schmidt’s syndrome – a clinical caseSíndrome de Schmidt – a propósito de um casodoença de Addisonsíndrome poliglandular auto-imuneAddison diseasepolyglandular autoimmune syndromeA 43-year-old woman was admitted because of nausea, vomiting, weakness and weight loss. On examination hypotension and cutaneous hyperpigmentation were detected. The sodium level was very low. Those findings suggested adrenal failure. The diagnosis of Addison disease was made because of low levels of cortisol and high levels of adrenocorticotropic hormone. Mild elevation of thyroid-stimulating hormone, normal levels of free thyroxine and free iodothyronine, associated to high levels of antithyroid antibodies, suggested chronic lymphocytic thyroiditis. The association beteween Addison disease and autoimmune thyroid disease is the hallmark of Schmidt’s syndrome. The patient showed a positive evolution after the beginning of glucocorticoid replacement therapy.Os autores apresentam o caso de uma doente de 43 anos internada por náuseas, vómitos, astenia intensa e emagrecimento. Na observação salientava-se hipotensão arterial e hiperpigmentação cutânea. Laboratorialmente verificou-se grave hiponatremia. Estes aspectos orientaram para o diagnóstico de insuficiência do córtex supra-renal. A constatação de valores baixos de cortisol e elevados de ACTH permitiu o diagnóstico de doença de Addison. Verificaram-se alterações da função tiroideia e anticorpos anti-tiroideus, compatíveis com tiroidite auto-imune. Esta associação com a doença de Addison é característica do síndrome de Schmidt. A evolução clínica e laboratorial após terapêutica com corticosteróides foi favorável.Sociedade Portuguesa de Medicina Interna2004-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://revista.spmi.pt/index.php/rpmi/article/view/1764Internal Medicine; Vol. 11 No. 4 (2004): Outubro/ Dezembro; 183-186Medicina Interna; Vol. 11 N.º 4 (2004): Outubro/ Dezembro; 183-1862183-99800872-671Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spmi.pt/index.php/rpmi/article/view/1764https://revista.spmi.pt/index.php/rpmi/article/view/1764/1224N. Raposo, JoséSousa, SusanaNamora, JoãoTomaz, AuroraRaimundo, LuísaFernandes, CarlosFerreira, José M.info:eu-repo/semantics/openAccess2023-04-01T06:11:40Zoai:oai.revista.spmi.pt:article/1764Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:48:17.822217Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Schmidt’s syndrome – a clinical case
Síndrome de Schmidt – a propósito de um caso
title Schmidt’s syndrome – a clinical case
spellingShingle Schmidt’s syndrome – a clinical case
N. Raposo, José
doença de Addison
síndrome poliglandular auto-imune
Addison disease
polyglandular autoimmune syndrome
title_short Schmidt’s syndrome – a clinical case
title_full Schmidt’s syndrome – a clinical case
title_fullStr Schmidt’s syndrome – a clinical case
title_full_unstemmed Schmidt’s syndrome – a clinical case
title_sort Schmidt’s syndrome – a clinical case
author N. Raposo, José
author_facet N. Raposo, José
Sousa, Susana
Namora, João
Tomaz, Aurora
Raimundo, Luísa
Fernandes, Carlos
Ferreira, José M.
author_role author
author2 Sousa, Susana
Namora, João
Tomaz, Aurora
Raimundo, Luísa
Fernandes, Carlos
Ferreira, José M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv N. Raposo, José
Sousa, Susana
Namora, João
Tomaz, Aurora
Raimundo, Luísa
Fernandes, Carlos
Ferreira, José M.
dc.subject.por.fl_str_mv doença de Addison
síndrome poliglandular auto-imune
Addison disease
polyglandular autoimmune syndrome
topic doença de Addison
síndrome poliglandular auto-imune
Addison disease
polyglandular autoimmune syndrome
description A 43-year-old woman was admitted because of nausea, vomiting, weakness and weight loss. On examination hypotension and cutaneous hyperpigmentation were detected. The sodium level was very low. Those findings suggested adrenal failure. The diagnosis of Addison disease was made because of low levels of cortisol and high levels of adrenocorticotropic hormone. Mild elevation of thyroid-stimulating hormone, normal levels of free thyroxine and free iodothyronine, associated to high levels of antithyroid antibodies, suggested chronic lymphocytic thyroiditis. The association beteween Addison disease and autoimmune thyroid disease is the hallmark of Schmidt’s syndrome. The patient showed a positive evolution after the beginning of glucocorticoid replacement therapy.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-31
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.spmi.pt/index.php/rpmi/article/view/1764
url https://revista.spmi.pt/index.php/rpmi/article/view/1764
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spmi.pt/index.php/rpmi/article/view/1764
https://revista.spmi.pt/index.php/rpmi/article/view/1764/1224
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
dc.source.none.fl_str_mv Internal Medicine; Vol. 11 No. 4 (2004): Outubro/ Dezembro; 183-186
Medicina Interna; Vol. 11 N.º 4 (2004): Outubro/ Dezembro; 183-186
2183-9980
0872-671X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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